CA2411155C - Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine - Google Patents
Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine Download PDFInfo
- Publication number
- CA2411155C CA2411155C CA002411155A CA2411155A CA2411155C CA 2411155 C CA2411155 C CA 2411155C CA 002411155 A CA002411155 A CA 002411155A CA 2411155 A CA2411155 A CA 2411155A CA 2411155 C CA2411155 C CA 2411155C
- Authority
- CA
- Canada
- Prior art keywords
- process according
- aqueous
- pyrimidine
- dimethoxy
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1439/00 | 2000-07-21 | ||
| CH14392000 | 2000-07-21 | ||
| PCT/EP2001/008373 WO2002008207A1 (en) | 2000-07-21 | 2001-07-19 | Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2411155A1 CA2411155A1 (en) | 2002-01-31 |
| CA2411155C true CA2411155C (en) | 2009-12-08 |
Family
ID=4565478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002411155A Expired - Fee Related CA2411155C (en) | 2000-07-21 | 2001-07-19 | Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6693194B2 (https=) |
| EP (1) | EP1301491A1 (https=) |
| JP (1) | JP3507483B1 (https=) |
| KR (1) | KR100516535B1 (https=) |
| CN (1) | CN1285581C (https=) |
| AR (1) | AR033677A1 (https=) |
| AU (2) | AU2001289701B2 (https=) |
| BR (1) | BR0112712A (https=) |
| CA (1) | CA2411155C (https=) |
| HU (1) | HUP0301038A3 (https=) |
| IL (1) | IL153662A0 (https=) |
| MX (1) | MXPA03000431A (https=) |
| PL (1) | PL362686A1 (https=) |
| RU (1) | RU2276142C2 (https=) |
| TW (1) | TWI288132B (https=) |
| UA (1) | UA75888C2 (https=) |
| WO (1) | WO2002008207A1 (https=) |
| ZA (1) | ZA200300510B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1786430E (pt) * | 2004-08-20 | 2013-06-04 | Buck Inst For Age Res | Pequenas moléculas que substituam ou agonizam a função p53 |
| WO2007117399A2 (en) | 2006-03-31 | 2007-10-18 | Janssen Pharmaceutica N.V. | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| SG192446A1 (en) | 2008-06-30 | 2013-08-30 | Janssen Pharmaceutica Nv | Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives |
| CN102137672B (zh) | 2008-06-30 | 2014-03-26 | 詹森药业有限公司 | 取代的嘧啶衍生物的制备方法 |
| CN101747283B (zh) * | 2008-12-11 | 2011-06-08 | 中国中化股份有限公司 | 一种制备4，6-二甲氧基-2-甲磺酰基嘧啶的方法 |
| CN105026376B (zh) * | 2013-02-18 | 2018-05-11 | 加尔达化学有限公司 | 用于制备双草醚钠及其中间体的方法 |
| PT2964229T (pt) | 2013-03-06 | 2020-03-23 | Janssen Pharmaceutica Nv | Moduladores de piridina benzimidazol-2-ilo do recetor h4 de histamina |
| CN112552244A (zh) * | 2020-12-22 | 2021-03-26 | 内蒙古科硕新材料科技有限公司 | 一种4,6-二甲氧基-2-甲磺酰基嘧啶的生产工艺 |
| CN115215805B (zh) * | 2022-08-11 | 2024-06-25 | 上海奥萝拉医药科技有限公司 | 一种2-氰基嘧啶的制备工艺 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3525977A1 (de) | 1985-07-20 | 1987-01-29 | Bayer Ag | Verfahren zur herstellung von 2-cyanamino-pyrimidin-derivaten |
| JP2561480B2 (ja) | 1987-08-06 | 1996-12-11 | イハラケミカル工業株式会社 | ４，６−ジアルコキシ−２−アルキルチオピリミジン類の製造方法 |
| US5149357A (en) | 1990-06-19 | 1992-09-22 | Fmc Corporation | Herbicidal substituted benzoylsulfonamides |
| KR100233068B1 (ko) * | 1991-11-26 | 1999-12-01 | 하인즈 모제르 | 2-치환된 4,6-디알콕시피리미딘의 제조방법 |
| TWI220428B (en) * | 1999-02-05 | 2004-08-21 | Syngenta Participations Ag | Method of producing thiobarbituric acid derivatives |
-
2001
- 2001-07-19 IL IL15366201A patent/IL153662A0/xx unknown
- 2001-07-19 US US10/332,248 patent/US6693194B2/en not_active Expired - Lifetime
- 2001-07-19 AU AU2001289701A patent/AU2001289701B2/en not_active Ceased
- 2001-07-19 HU HU0301038A patent/HUP0301038A3/hu not_active Application Discontinuation
- 2001-07-19 UA UA2003021454A patent/UA75888C2/uk unknown
- 2001-07-19 TW TW090117644A patent/TWI288132B/zh not_active IP Right Cessation
- 2001-07-19 PL PL01362686A patent/PL362686A1/xx not_active Application Discontinuation
- 2001-07-19 JP JP2002514113A patent/JP3507483B1/ja not_active Expired - Fee Related
- 2001-07-19 CN CNB018131492A patent/CN1285581C/zh not_active Expired - Fee Related
- 2001-07-19 WO PCT/EP2001/008373 patent/WO2002008207A1/en not_active Ceased
- 2001-07-19 KR KR10-2003-7000881A patent/KR100516535B1/ko not_active Expired - Fee Related
- 2001-07-19 BR BR0112712-8A patent/BR0112712A/pt not_active Application Discontinuation
- 2001-07-19 MX MXPA03000431A patent/MXPA03000431A/es active IP Right Grant
- 2001-07-19 AU AU8970101A patent/AU8970101A/xx active Pending
- 2001-07-19 RU RU2003104800/04A patent/RU2276142C2/ru not_active IP Right Cessation
- 2001-07-19 CA CA002411155A patent/CA2411155C/en not_active Expired - Fee Related
- 2001-07-19 EP EP01969442A patent/EP1301491A1/en not_active Ceased
- 2001-07-20 AR ARP010103448A patent/AR033677A1/es not_active Application Discontinuation
-
2003
- 2003-01-20 ZA ZA200300510A patent/ZA200300510B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0301038A2 (hu) | 2003-08-28 |
| IL153662A0 (en) | 2003-07-06 |
| ZA200300510B (en) | 2004-04-20 |
| US20030135047A1 (en) | 2003-07-17 |
| AU8970101A (en) | 2002-02-05 |
| AR033677A1 (es) | 2004-01-07 |
| JP3507483B1 (ja) | 2004-03-15 |
| RU2276142C2 (ru) | 2006-05-10 |
| BR0112712A (pt) | 2003-05-20 |
| JP2004504387A (ja) | 2004-02-12 |
| MXPA03000431A (es) | 2003-06-24 |
| EP1301491A1 (en) | 2003-04-16 |
| CN1443175A (zh) | 2003-09-17 |
| US6693194B2 (en) | 2004-02-17 |
| HUP0301038A3 (en) | 2004-06-28 |
| KR20030047992A (ko) | 2003-06-18 |
| UA75888C2 (uk) | 2006-06-15 |
| CN1285581C (zh) | 2006-11-22 |
| CA2411155A1 (en) | 2002-01-31 |
| AU2001289701B2 (en) | 2004-06-24 |
| TWI288132B (en) | 2007-10-11 |
| WO2002008207A1 (en) | 2002-01-31 |
| KR100516535B1 (ko) | 2005-09-22 |
| PL362686A1 (en) | 2004-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20170719 |