CN1278727A - 单胺氧化酶抑制剂和h5－ht1B拮抗剂或部分激动剂的组合 - Google Patents
单胺氧化酶抑制剂和h5－ht1B拮抗剂或部分激动剂的组合 Download PDFInfo
- Publication number
- CN1278727A CN1278727A CN98811114A CN98811114A CN1278727A CN 1278727 A CN1278727 A CN 1278727A CN 98811114 A CN98811114 A CN 98811114A CN 98811114 A CN98811114 A CN 98811114A CN 1278727 A CN1278727 A CN 1278727A
- Authority
- CN
- China
- Prior art keywords
- naphthyl
- formula
- methyl
- combination
- morpholinobenzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE97033765 | 1997-09-18 | ||
| SE9703376A SE9703376D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1278727A true CN1278727A (zh) | 2001-01-03 |
Family
ID=20408296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98811114A Pending CN1278727A (zh) | 1997-09-18 | 1998-09-09 | 单胺氧化酶抑制剂和h5－ht1B拮抗剂或部分激动剂的组合 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6159970A (https=) |
| EP (1) | EP1014986B1 (https=) |
| JP (1) | JP2001516719A (https=) |
| KR (2) | KR20010024084A (https=) |
| CN (1) | CN1278727A (https=) |
| AR (1) | AR013503A1 (https=) |
| AT (1) | ATE270889T1 (https=) |
| AU (1) | AU752719B2 (https=) |
| BR (1) | BR9812236A (https=) |
| CA (1) | CA2302204A1 (https=) |
| DE (1) | DE69825062T2 (https=) |
| DK (1) | DK1014986T3 (https=) |
| EE (1) | EE200000146A (https=) |
| ES (1) | ES2222603T3 (https=) |
| HU (1) | HUP0100621A2 (https=) |
| ID (1) | ID25789A (https=) |
| IL (1) | IL134775A0 (https=) |
| IS (1) | IS5401A (https=) |
| MX (1) | MXPA00002616A (https=) |
| NO (1) | NO20001400L (https=) |
| PL (1) | PL339368A1 (https=) |
| PT (1) | PT1014986E (https=) |
| SE (1) | SE9703376D0 (https=) |
| SK (1) | SK2832000A3 (https=) |
| TR (1) | TR200000725T2 (https=) |
| WO (1) | WO1999013878A1 (https=) |
| ZA (1) | ZA987804B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110179988A (zh) * | 2019-07-10 | 2019-08-30 | 王大伟 | 五羟色胺再摄取抑制剂和单胺氧化酶抑制剂联合在制备治疗抑郁症或早泄药物中的应用 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957948A (en) * | 1988-05-05 | 1990-09-18 | Interface, Inc. | Biocidal protective coating for heat exchanger coils |
| SE9601110D0 (sv) | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| WO2002066454A1 (fr) * | 2001-02-21 | 2002-08-29 | Sankyo Company, Limited | Derives de chromene |
| ATE424825T1 (de) * | 2001-07-20 | 2009-03-15 | Psychogenics Inc | Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| US20090054453A1 (en) * | 2006-03-17 | 2009-02-26 | Lilian Alcaraz | Novel Tetralins as 5-HT6 Modulators |
| EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| AU2008220785B2 (en) | 2007-03-01 | 2013-02-21 | Vivoryon Therapeutics N.V. | New use of glutaminyl cyclase inhibitors |
| JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| JP5688745B2 (ja) | 2010-03-10 | 2015-03-25 | プロビオドルグ エージー | グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤 |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| WO2024130044A1 (en) * | 2022-12-14 | 2024-06-20 | Luminous Mind Inc. | Treatment of psychological factors affecting other medical conditions (pfaomc) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| PT533268E (pt) * | 1991-09-18 | 2002-02-28 | Glaxo Group Ltd | Derivados de benzanilida como antagonistas de 5-ht1d |
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
-
1997
- 1997-09-18 SE SE9703376A patent/SE9703376D0/xx unknown
-
1998
- 1998-08-27 ZA ZA987804A patent/ZA987804B/xx unknown
- 1998-09-09 CA CA002302204A patent/CA2302204A1/en not_active Abandoned
- 1998-09-09 MX MXPA00002616A patent/MXPA00002616A/es unknown
- 1998-09-09 HU HU0100621A patent/HUP0100621A2/hu unknown
- 1998-09-09 AU AU91931/98A patent/AU752719B2/en not_active Ceased
- 1998-09-09 EP EP98944376A patent/EP1014986B1/en not_active Expired - Lifetime
- 1998-09-09 TR TR2000/00725T patent/TR200000725T2/xx unknown
- 1998-09-09 BR BR9812236-3A patent/BR9812236A/pt not_active IP Right Cessation
- 1998-09-09 PL PL98339368A patent/PL339368A1/xx unknown
- 1998-09-09 WO PCT/SE1998/001602 patent/WO1999013878A1/en not_active Ceased
- 1998-09-09 SK SK283-2000A patent/SK2832000A3/sk unknown
- 1998-09-09 AT AT98944376T patent/ATE270889T1/de not_active IP Right Cessation
- 1998-09-09 CN CN98811114A patent/CN1278727A/zh active Pending
- 1998-09-09 KR KR1020007002830A patent/KR20010024084A/ko not_active Withdrawn
- 1998-09-09 ES ES98944376T patent/ES2222603T3/es not_active Expired - Lifetime
- 1998-09-09 ID IDW20000522D patent/ID25789A/id unknown
- 1998-09-09 US US09/171,578 patent/US6159970A/en not_active Expired - Fee Related
- 1998-09-09 DE DE69825062T patent/DE69825062T2/de not_active Expired - Fee Related
- 1998-09-09 PT PT98944376T patent/PT1014986E/pt unknown
- 1998-09-09 EE EEP200000146A patent/EE200000146A/xx unknown
- 1998-09-09 KR KR1020007002835A patent/KR20010024087A/ko not_active Ceased
- 1998-09-09 DK DK98944376T patent/DK1014986T3/da active
- 1998-09-09 JP JP2000511500A patent/JP2001516719A/ja active Pending
- 1998-09-09 IL IL13477598A patent/IL134775A0/xx unknown
- 1998-09-17 AR ARP980104635A patent/AR013503A1/es unknown
-
2000
- 2000-03-14 IS IS5401A patent/IS5401A/is unknown
- 2000-03-17 NO NO20001400A patent/NO20001400L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110179988A (zh) * | 2019-07-10 | 2019-08-30 | 王大伟 | 五羟色胺再摄取抑制剂和单胺氧化酶抑制剂联合在制备治疗抑郁症或早泄药物中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| IS5401A (is) | 2000-03-14 |
| EE200000146A (et) | 2001-02-15 |
| ES2222603T3 (es) | 2005-02-01 |
| ATE270889T1 (de) | 2004-07-15 |
| DE69825062T2 (de) | 2005-08-25 |
| EP1014986B1 (en) | 2004-07-14 |
| DK1014986T3 (da) | 2004-10-25 |
| KR20010024084A (ko) | 2001-03-26 |
| HUP0100621A2 (hu) | 2001-08-28 |
| AU752719B2 (en) | 2002-09-26 |
| BR9812236A (pt) | 2000-07-18 |
| ZA987804B (en) | 1999-03-18 |
| NO20001400D0 (no) | 2000-03-17 |
| KR20010024087A (ko) | 2001-03-26 |
| PT1014986E (pt) | 2004-10-29 |
| CA2302204A1 (en) | 1999-03-25 |
| SE9703376D0 (sv) | 1997-09-18 |
| EP1014986A1 (en) | 2000-07-05 |
| IL134775A0 (en) | 2001-04-30 |
| AU9193198A (en) | 1999-04-05 |
| TR200000725T2 (tr) | 2000-08-21 |
| JP2001516719A (ja) | 2001-10-02 |
| WO1999013878A1 (en) | 1999-03-25 |
| PL339368A1 (en) | 2000-12-18 |
| US6159970A (en) | 2000-12-12 |
| DE69825062D1 (de) | 2004-08-19 |
| AR013503A1 (es) | 2000-12-27 |
| ID25789A (id) | 2000-11-02 |
| MXPA00002616A (es) | 2002-04-24 |
| NO20001400L (no) | 2000-05-05 |
| SK2832000A3 (en) | 2000-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |