CN1273140C - 导泻组合物 - Google Patents

导泻组合物 Download PDF

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Publication number
CN1273140C
CN1273140C CNB028101847A CN02810184A CN1273140C CN 1273140 C CN1273140 C CN 1273140C CN B028101847 A CNB028101847 A CN B028101847A CN 02810184 A CN02810184 A CN 02810184A CN 1273140 C CN1273140 C CN 1273140C
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CN
China
Prior art keywords
compound
alkyl
composition
hydroxy
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB028101847A
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English (en)
Chinese (zh)
Other versions
CN1509176A (zh
Inventor
上野隆司
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sucampo GmbH
Original Assignee
Sucampo GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sucampo GmbH filed Critical Sucampo GmbH
Publication of CN1509176A publication Critical patent/CN1509176A/zh
Application granted granted Critical
Publication of CN1273140C publication Critical patent/CN1273140C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
CNB028101847A 2001-05-18 2002-05-17 导泻组合物 Expired - Lifetime CN1273140C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29163501P 2001-05-18 2001-05-18
US60/291,635 2001-05-18

Publications (2)

Publication Number Publication Date
CN1509176A CN1509176A (zh) 2004-06-30
CN1273140C true CN1273140C (zh) 2006-09-06

Family

ID=23121127

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028101847A Expired - Lifetime CN1273140C (zh) 2001-05-18 2002-05-17 导泻组合物

Country Status (18)

Country Link
US (2) US6956056B2 (enExample)
EP (1) EP1389116B1 (enExample)
JP (1) JP4597481B2 (enExample)
KR (1) KR100867295B1 (enExample)
CN (1) CN1273140C (enExample)
AR (3) AR035242A1 (enExample)
AT (1) ATE387204T1 (enExample)
AU (1) AU2002307725B2 (enExample)
BR (1) BR0209863A (enExample)
CA (1) CA2445651C (enExample)
DE (1) DE60225266T2 (enExample)
DK (1) DK1389116T3 (enExample)
ES (1) ES2301681T3 (enExample)
MX (1) MXPA03010510A (enExample)
NZ (1) NZ529406A (enExample)
PT (1) PT1389116E (enExample)
TW (2) TWI324589B (enExample)
WO (1) WO2002094274A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI302100B (en) * 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
AR037524A1 (es) 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
WO2004037268A1 (en) * 2002-10-23 2004-05-06 Sucampo Ag Prostaglandin compounds for the treatment of obesity
MXPA05006981A (es) * 2002-12-27 2005-12-14 Sucampo Ag Derivados de prostaglandinas para el tratamiento de la molestia abdominal.
US7049319B2 (en) 2003-09-23 2006-05-23 Semaan Abboud Colon cleansing composition and method
TWI387454B (zh) 2004-09-02 2013-03-01 蘇坎波公司 治療胃腸道疾病之方法及組成物
US20070071793A1 (en) * 2005-09-23 2007-03-29 Leon Clark Cure for prostate enlargement frequency of urination and cancer
CA2819844C (en) * 2006-02-07 2015-09-15 R-Tech Ueno, Ltd. Prostaglandin derivatives
CN102050808B (zh) * 2009-11-02 2014-03-12 上海天伟生物制药有限公司 一种前列腺素中间体的制备方法
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
US11534404B2 (en) 2016-10-06 2022-12-27 Sucampo Ag Multilayer beads for pharmaceutical use
US10457623B1 (en) * 2018-07-13 2019-10-29 Chirogate International Inc. Process for the preparation of Lubiprostone and intermediates thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1396206A (en) * 1972-04-27 1975-06-04 Upjohn Co Prostaglandins and the preparation thereof
ZA744581B (en) * 1973-07-20 1975-07-30 Upjohn Co Prostoglandin analogs
US3969376A (en) * 1973-07-20 1976-07-13 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin E1 analogs
US3969381A (en) * 1975-02-21 1976-07-13 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin B1 analogs
US3969379A (en) * 1975-02-21 1976-07-13 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin A1 analogs
GB8305697D0 (en) * 1983-03-02 1983-04-07 Erba Farmitalia Pharmaceutical compositions
EP0153858A3 (en) * 1984-02-29 1985-12-11 The Upjohn Company The therapeutic use of prostaglandins
JPH0681728B2 (ja) * 1987-10-02 1994-10-19 株式会社上野製薬応用研究所 下 剤
DE3873007T2 (de) * 1987-10-02 1992-12-03 Ueno Seiyaku Oyo Kenkyujo Kk Kathartica.
JP2579193B2 (ja) 1988-07-19 1997-02-05 小野薬品工業株式会社 １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体
EP0455448B1 (en) * 1990-05-01 1998-12-09 R-Tech Ueno Ltd. Treatment of pancreatic disease with 15-keto-prostaglandin E compounds
CA2046069C (en) * 1990-07-10 2002-04-09 Ryuji Ueno Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
ES2093774T3 (es) * 1991-03-14 1997-01-01 R Tech Ueno Ltd Estimulacion de la curacion de heridas con un compuesto 15-cetoprostaglandina.
JP3183615B2 (ja) * 1994-06-03 2001-07-09 株式会社アールテック・ウエノ 肝・胆道系疾患処置剤
JP3187438B2 (ja) * 1996-06-10 2001-07-11 株式会社アールテック・ウエノ エンドセリン拮抗剤
EP1420794B1 (en) * 2001-08-31 2017-12-27 Sucampo AG Prostaglandin analogs as chloride channel openers

Also Published As

Publication number Publication date
DE60225266D1 (de) 2008-04-10
AR098744A2 (es) 2016-06-08
CA2445651C (en) 2011-08-09
CA2445651A1 (en) 2002-11-28
US7459583B2 (en) 2008-12-02
DK1389116T3 (da) 2008-06-23
BR0209863A (pt) 2004-06-08
EP1389116A1 (en) 2004-02-18
TWI320711B (en) 2010-02-21
PT1389116E (pt) 2008-04-11
JP4597481B2 (ja) 2010-12-15
KR100867295B1 (ko) 2008-11-06
EP1389116B1 (en) 2008-02-27
US6956056B2 (en) 2005-10-18
WO2002094274A1 (en) 2002-11-28
TW200944210A (en) 2009-11-01
CN1509176A (zh) 2004-06-30
ATE387204T1 (de) 2008-03-15
KR20040020055A (ko) 2004-03-06
AR035242A1 (es) 2004-05-05
JP2004529960A (ja) 2004-09-30
AU2002307725B2 (en) 2008-07-10
AR110149A2 (es) 2019-02-27
US20030022933A1 (en) 2003-01-30
DE60225266T2 (de) 2009-03-19
NZ529406A (en) 2005-09-30
MXPA03010510A (es) 2004-03-02
US20050261375A1 (en) 2005-11-24
TWI324589B (en) 2010-05-11
ES2301681T3 (es) 2008-07-01

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Granted publication date: 20060906