NZ529406A - Halogenated prostaglandin derivatives for treating constipation and cleansing the gastrointestinal tract - Google Patents

Halogenated prostaglandin derivatives for treating constipation and cleansing the gastrointestinal tract

Info

Publication number
NZ529406A
NZ529406A NZ529406A NZ52940602A NZ529406A NZ 529406 A NZ529406 A NZ 529406A NZ 529406 A NZ529406 A NZ 529406A NZ 52940602 A NZ52940602 A NZ 52940602A NZ 529406 A NZ529406 A NZ 529406A
Authority
NZ
New Zealand
Prior art keywords
compound
alkyl
hydroxy
halogen
hydrogen
Prior art date
Application number
NZ529406A
Other languages
English (en)
Inventor
Ryuji Ueno
Original Assignee
Sucampo Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sucampo Ag filed Critical Sucampo Ag
Publication of NZ529406A publication Critical patent/NZ529406A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
NZ529406A 2001-05-18 2002-05-17 Halogenated prostaglandin derivatives for treating constipation and cleansing the gastrointestinal tract NZ529406A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29163501P 2001-05-18 2001-05-18
PCT/JP2002/004768 WO2002094274A1 (en) 2001-05-18 2002-05-17 Cathartic composition

Publications (1)

Publication Number Publication Date
NZ529406A true NZ529406A (en) 2005-09-30

Family

ID=23121127

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ529406A NZ529406A (en) 2001-05-18 2002-05-17 Halogenated prostaglandin derivatives for treating constipation and cleansing the gastrointestinal tract

Country Status (18)

Country Link
US (2) US6956056B2 (enExample)
EP (1) EP1389116B1 (enExample)
JP (1) JP4597481B2 (enExample)
KR (1) KR100867295B1 (enExample)
CN (1) CN1273140C (enExample)
AR (3) AR035242A1 (enExample)
AT (1) ATE387204T1 (enExample)
AU (1) AU2002307725B2 (enExample)
BR (1) BR0209863A (enExample)
CA (1) CA2445651C (enExample)
DE (1) DE60225266T2 (enExample)
DK (1) DK1389116T3 (enExample)
ES (1) ES2301681T3 (enExample)
MX (1) MXPA03010510A (enExample)
NZ (1) NZ529406A (enExample)
PT (1) PT1389116E (enExample)
TW (2) TWI320711B (enExample)
WO (1) WO2002094274A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI302100B (en) * 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
AR037524A1 (es) 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
ES2379652T3 (es) * 2002-10-23 2012-04-30 Sucampo Ag Compuestos de prostaglandina para el tratamiento de obesidad
JP4889219B2 (ja) 2002-12-27 2012-03-07 スキャンポ・アーゲー 腹部不快感の処置のためのプロスタグランジン誘導体
US7049319B2 (en) 2003-09-23 2006-05-23 Semaan Abboud Colon cleansing composition and method
TWI387454B (zh) 2004-09-02 2013-03-01 蘇坎波公司 治療胃腸道疾病之方法及組成物
US20070071793A1 (en) * 2005-09-23 2007-03-29 Leon Clark Cure for prostate enlargement frequency of urination and cancer
CA2637797C (en) * 2006-02-07 2015-03-17 R-Tech Ueno, Ltd. Method for preparing prostaglandin derivative
CN102050808B (zh) * 2009-11-02 2014-03-12 上海天伟生物制药有限公司 一种前列腺素中间体的制备方法
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
US11534404B2 (en) 2016-10-06 2022-12-27 Sucampo Ag Multilayer beads for pharmaceutical use
US10457623B1 (en) * 2018-07-13 2019-10-29 Chirogate International Inc. Process for the preparation of Lubiprostone and intermediates thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1396206A (en) * 1972-04-27 1975-06-04 Upjohn Co Prostaglandins and the preparation thereof
ZA744581B (en) * 1973-07-20 1975-07-30 Upjohn Co Prostoglandin analogs
US3969376A (en) * 1973-07-20 1976-07-13 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin E1 analogs
US3969379A (en) * 1975-02-21 1976-07-13 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin A1 analogs
US3969381A (en) * 1975-02-21 1976-07-13 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin B1 analogs
GB8305697D0 (en) * 1983-03-02 1983-04-07 Erba Farmitalia Pharmaceutical compositions
EP0153858A3 (en) * 1984-02-29 1985-12-11 The Upjohn Company The therapeutic use of prostaglandins
EP0310305B1 (en) * 1987-10-02 1992-07-22 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Cathartics
JPH0681728B2 (ja) * 1987-10-02 1994-10-19 株式会社上野製薬応用研究所 下 剤
JP2579193B2 (ja) 1988-07-19 1997-02-05 小野薬品工業株式会社 １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体
DE69130586T2 (de) 1990-05-01 1999-06-17 R-Tech Ueno, Ltd., Osaka Behandlung von Pankreaskrankheit mit 15-keto-Prostaglandin E-Derivaten
CA2046069C (en) * 1990-07-10 2002-04-09 Ryuji Ueno Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
ATE141794T1 (de) * 1991-03-14 1996-09-15 R Tech Ueno Ltd Stimulierung von wundheilung mit 15-keto- prostaglandinverbindungen
JP3183615B2 (ja) * 1994-06-03 2001-07-09 株式会社アールテック・ウエノ 肝・胆道系疾患処置剤
KR19990036322A (ko) * 1996-06-10 1999-05-25 류지 우에노 엔도텔린길항제
JP4786866B2 (ja) * 2001-08-31 2011-10-05 スキャンポ・アーゲー クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Also Published As

Publication number Publication date
AU2002307725B2 (en) 2008-07-10
US6956056B2 (en) 2005-10-18
KR20040020055A (ko) 2004-03-06
WO2002094274A1 (en) 2002-11-28
MXPA03010510A (es) 2004-03-02
EP1389116B1 (en) 2008-02-27
TWI324589B (en) 2010-05-11
US20050261375A1 (en) 2005-11-24
AR098744A2 (es) 2016-06-08
AR110149A2 (es) 2019-02-27
TW200944210A (en) 2009-11-01
KR100867295B1 (ko) 2008-11-06
US20030022933A1 (en) 2003-01-30
ATE387204T1 (de) 2008-03-15
BR0209863A (pt) 2004-06-08
JP4597481B2 (ja) 2010-12-15
JP2004529960A (ja) 2004-09-30
PT1389116E (pt) 2008-04-11
DK1389116T3 (da) 2008-06-23
ES2301681T3 (es) 2008-07-01
US7459583B2 (en) 2008-12-02
CN1273140C (zh) 2006-09-06
AR035242A1 (es) 2004-05-05
TWI320711B (en) 2010-02-21
CA2445651A1 (en) 2002-11-28
EP1389116A1 (en) 2004-02-18
CA2445651C (en) 2011-08-09
CN1509176A (zh) 2004-06-30
DE60225266T2 (de) 2009-03-19
DE60225266D1 (de) 2008-04-10

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Free format text: PATENT RENEWED FOR 7 YEARS UNTIL 17 MAY 2022 BY HENRY HUGHES IP LIMITED

Effective date: 20140901

EXPY Patent expired