CN1263743C - 用于治疗的吗啉代基取代的化合物 - Google Patents

用于治疗的吗啉代基取代的化合物 Download PDF

Info

Publication number
CN1263743C
CN1263743C CNB018067522A CN01806752A CN1263743C CN 1263743 C CN1263743 C CN 1263743C CN B018067522 A CNB018067522 A CN B018067522A CN 01806752 A CN01806752 A CN 01806752A CN 1263743 C CN1263743 C CN 1263743C
Authority
CN
China
Prior art keywords
morpholino
pyrido
pyrimidin
methyl
purposes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018067522A
Other languages
English (en)
Chinese (zh)
Other versions
CN1418195A (zh
Inventor
A·D·罗伯森
S·杰克森
V·肯彻
C·艾普
H·帕拉巴哈兰
P·汤普森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Kinasia Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kinasia Co ltd filed Critical Kinasia Co ltd
Publication of CN1418195A publication Critical patent/CN1418195A/zh
Application granted granted Critical
Publication of CN1263743C publication Critical patent/CN1263743C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
CNB018067522A 2000-01-24 2001-01-24 用于治疗的吗啉代基取代的化合物 Expired - Fee Related CN1263743C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17735100P 2000-01-24 2000-01-24
US60/177,351 2000-01-24
US22582600P 2000-08-17 2000-08-17
US60/225,826 2000-08-17

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CNA2006100847155A Division CN1891699A (zh) 2000-01-24 2001-01-24 用于治疗的吗啉代基取代的化合物
CNA200610084723XA Division CN1891693A (zh) 2000-01-24 2001-01-24 用于治疗的吗啉代基取代的化合物

Publications (2)

Publication Number Publication Date
CN1418195A CN1418195A (zh) 2003-05-14
CN1263743C true CN1263743C (zh) 2006-07-12

Family

ID=26873182

Family Applications (3)

Application Number Title Priority Date Filing Date
CNB018067522A Expired - Fee Related CN1263743C (zh) 2000-01-24 2001-01-24 用于治疗的吗啉代基取代的化合物
CNA2006100847155A Pending CN1891699A (zh) 2000-01-24 2001-01-24 用于治疗的吗啉代基取代的化合物
CNA200610084723XA Pending CN1891693A (zh) 2000-01-24 2001-01-24 用于治疗的吗啉代基取代的化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CNA2006100847155A Pending CN1891699A (zh) 2000-01-24 2001-01-24 用于治疗的吗啉代基取代的化合物
CNA200610084723XA Pending CN1891693A (zh) 2000-01-24 2001-01-24 用于治疗的吗啉代基取代的化合物

Country Status (14)

Country Link
US (4) US6977255B2 (enExample)
EP (2) EP1857443B1 (enExample)
JP (1) JP4820518B2 (enExample)
CN (3) CN1263743C (enExample)
AT (2) ATE363471T1 (enExample)
AU (2) AU2001230426C1 (enExample)
CA (1) CA2398163C (enExample)
CY (1) CY1108023T1 (enExample)
DE (1) DE60128655T2 (enExample)
DK (1) DK1257537T3 (enExample)
ES (1) ES2286093T3 (enExample)
NZ (1) NZ520300A (enExample)
PT (1) PT1257537E (enExample)
WO (1) WO2001053266A1 (enExample)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
IL152275A0 (en) 2000-04-25 2003-05-29 Icos Corp Inhibitors of human phosphatidyl-inositol 3-kinase delta
GB0119865D0 (en) * 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB2405870B (en) * 2001-08-14 2005-07-06 Cancer Rec Tech Ltd DNA-PK inhibitors
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
WO2003022271A1 (fr) * 2001-09-05 2003-03-20 Eisai C0. Ltd. Inhibiteur d'activation lymphocytaire et remede pour maladie auto-immune
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
MY156407A (en) 2002-02-28 2016-02-26 Novartis Ag 5-phenylthiazole derivatives and use as p13 kinase inhibitors
EP2311818B1 (en) * 2002-02-28 2013-01-16 Novartis AG Combination of a 5-phenylthiazole compound as PI3 kinase inhibitor with an antiinflammatory, bronchodilatory or antihistamine drug
NZ538420A (en) * 2002-08-16 2007-06-29 Kinacia Pty Ltd Inhibition of phosphoinositide 3-kinase beta
CN100430389C (zh) * 2002-08-16 2008-11-05 阿斯利康(瑞典)有限公司 抑制磷酸肌醇3-激酶β
AU2003265585B2 (en) * 2002-08-26 2008-07-03 Takeda Pharmaceutical Company Limited Calcium receptor modulating compound and use thereof
CA2508601A1 (en) 2002-12-06 2004-06-24 Warner-Lambert Company Llc Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k
GB0305152D0 (en) * 2003-03-06 2003-04-09 Novartis Ag Organic compounds
EP1611119A1 (en) * 2003-04-03 2006-01-04 Semafore Pharmaceuticals, Inc. Pi-3 kinase inhibitor prodrugs
CA2522595A1 (en) 2003-04-03 2004-10-28 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
JP2006526608A (ja) * 2003-06-05 2006-11-24 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー Ｐｉ３ｋ活性を有する治療薬としてのテトラゾールベンゾフランカルボキシアミド
EP1636212B1 (en) * 2003-06-05 2007-06-27 Warner-Lambert Company LLC Cycloalkylsulfanyl substituted benzo¬b|thiophenes as therapeutic agents
US20040259926A1 (en) * 2003-06-05 2004-12-23 Bruendl Michelle M. 3-Aryloxy and 3-heteroaryloxy substituted benzo[b]thiophenes as therapeutic agents
US7429660B2 (en) 2003-08-13 2008-09-30 Kudos Pharmaceuticals Limited ATM inhibitors
CA2536930A1 (en) * 2003-09-04 2005-03-17 Warner-Lambert Company Llc Halo substituted benzo`b! thiophenes with pi3k inhibitory activity as therapeutic agents
JP2007509924A (ja) * 2003-10-31 2007-04-19 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー ホスホイノシチド−３−キナーゼ（ｐｉ３ｋ）阻害剤としてのピリミジン
EP1716151A1 (en) * 2004-01-26 2006-11-02 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
ES2605792T3 (es) 2004-05-13 2017-03-16 Icos Corporation Quinazolinona usada como inhibidor de la fosfatidilinositol 3-quinasa delta humana
CN1300163C (zh) * 2004-06-23 2007-02-14 南京大学 3－羟基色原酮糖苷及其制法和用途
KR20070059156A (ko) 2004-09-20 2007-06-11 쿠도스 파마슈티칼스 리미티드 Ｄｎａ－ｐｋ 억제제
WO2006085067A1 (en) 2005-02-09 2006-08-17 Kudos Pharmaceuticals Limited Atm inhibitors
AR054438A1 (es) 2005-04-15 2007-06-27 Kudos Pharm Ltd Inhibidores de adn -pk
WO2007127366A2 (en) 2006-04-25 2007-11-08 Targegen, Inc. Kinase inhibitors and methods of use thereof
AU2007262670B2 (en) * 2006-06-22 2012-12-20 Prana Biotechnology Limited Method of treatment of glioma brain tumour
WO2008102932A1 (en) * 2007-02-21 2008-08-28 Biobud Co., Ltd. Compositions for treating hyperproliferative vascular disorders and cancers
EP2157092A4 (en) 2007-04-11 2011-04-13 Ajinomoto Kk Remedy for diabetes
WO2008150827A1 (en) * 2007-05-29 2008-12-11 Smithkline Beecham Corporation Naphthyridine, derivatives as p13 kinase inhibitors
WO2009008991A2 (en) * 2007-07-06 2009-01-15 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health Dna-pkcs modulates energy regulation and brain function
BRPI0906805A2 (pt) * 2008-01-25 2015-07-14 Astrazeneca Ab Composto, processo para preparar o enanciômero puro, composição farmacêutica, uso do enanciômero puro, métodos para prevenir ou tratar doença em um animal de sangue quente, e, combinação
WO2009129372A1 (en) * 2008-04-18 2009-10-22 Shenogen Pharma Group Ltd. Compounds and methods for treating estrogen receptor-related diseases
KR101679089B1 (ko) 2008-09-29 2016-11-23 서트리스 파마슈티컬즈, 인코포레이티드 시르투인 조절제로서의 크로메논 유사체
US8110578B2 (en) * 2008-10-27 2012-02-07 Signal Pharmaceuticals, Llc Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
SG10201703911XA (en) 2008-11-13 2017-06-29 Gilead Calistoga Llc Therapies for hematologic malignancies
EP2448932B1 (fr) 2009-07-02 2014-03-05 Sanofi Nouveaux derives de 6-morpholin-4-yl-pyrimidin-4-(3h)-one, leur preparation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
WO2011001114A1 (fr) 2009-07-02 2011-01-06 Sanofi-Aventis Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
JP5663571B2 (ja) 2009-07-02 2015-02-04 サノフイ 新規２，３−ジヒドロ−１Ｈ−イミダゾ｛１，２−ａ｝ピリミジン−５−オン誘導体、これらの調製およびこれらの薬学的使用
RU2561130C2 (ru) 2009-07-02 2015-08-20 Санофи НОВЫЕ ПРОИЗВОДНЫЕ 1,2,3,4-ТЕТРАГИДРОПИРИМИДО{1,2-a}ПИРИМИДИН-6-ОНА, ИХ ПОЛУЧЕНИЕ И ФАРМАЦЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ
US8691829B2 (en) 2009-07-21 2014-04-08 Gilead Calistoga Llc Treatment of liver disorders with PI3K inhibitors
US8399460B2 (en) 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives
IT1403156B1 (it) 2010-12-01 2013-10-04 Università Degli Studi Di Torino Inibitori di fosfatidilinositol 3-chinasi, relative composizioni ed usi.
FR2969612B1 (fr) * 2010-12-23 2013-02-08 Sanofi Aventis Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique
HUE024504T2 (en) 2010-12-23 2016-01-28 Sanofi Sa Pyrimidine derivatives, a process for their preparation and their use in medicine
FR2969613B1 (fr) * 2010-12-23 2013-02-08 Sanofi Aventis Nouveaux derives de 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one, leur preparation et leur utilisation pharmaceutique
PL2658844T3 (pl) 2010-12-28 2017-04-28 Sanofi Nowe pochodne pirymidyn, ich wytwarzanie i ich zastosowanie farmaceutyczne jako inhibitorów fosforylacji AKT(pkb)
ES2648154T3 (es) 2012-01-26 2017-12-28 Daiichi Sankyo Company, Limited Derivado de cromona que tiene un efecto promotor de la osteogénesis
MX354074B (es) * 2012-02-10 2018-02-12 Ptc Therapeutics Inc Compuestos para tratar la atrofia muscular espinal.
JP6092264B2 (ja) 2012-03-01 2017-03-08 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋委縮症を処置するための化合物
CN106146506A (zh) 2012-03-05 2016-11-23 吉利德卡利斯托加公司 (s)‑2‑(1‑(9h‑嘌呤‑6‑基氨基)丙基)‑5‑氟‑3‑苯基喹唑啉‑4(3h)‑酮的多晶型物
CN104470909B (zh) 2012-03-23 2018-04-24 Ptc医疗公司 用于治疗脊髓性肌萎缩的化合物
ITMI20120514A1 (it) * 2012-03-29 2013-09-30 Cnr Consiglio Naz Delle Ric Erche Agente terapeutico per il trattamento dei vasi sanguigni
FR2992314B1 (fr) 2012-06-22 2015-10-16 Sanofi Sa Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique
US10195202B2 (en) 2013-12-19 2019-02-05 Ptc Therapeutics, Inc. Methods for modulating the amount of RNA transcripts
WO2015095605A1 (en) 2013-12-20 2015-06-25 Gilead Calistoga Llc Polymorphic forms of a hydrochloride salt of (s) -2-(9h-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3h) -one
EP3083630B1 (en) 2013-12-20 2019-08-21 Gilead Calistoga LLC Process methods for phosphatidylinositol 3-kinase inhibitors
AU2015274696B2 (en) 2014-06-13 2018-09-27 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
EP3298017B1 (en) * 2015-05-20 2019-08-14 H. Hoffnabb-La Roche Ag Compounds for treating spinal muscular atrophy
EP4249472A3 (en) 2015-05-30 2023-12-13 PTC Therapeutics, Inc. Methods for modulating rna splicing
MX391850B (es) 2015-12-10 2025-03-19 Ptc Therapeutics Inc Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington
MX382300B (es) 2015-12-17 2025-03-13 Alonbio Ltd Moléculas pequeñas para inhibir la actividad de quimiocinas y/o el crecimiento de células cancerosas.
EP3390378B1 (en) 2015-12-17 2022-03-30 AlonBio Ltd. Small molecules against cancer
US11091483B2 (en) * 2016-08-12 2021-08-17 Madera Therapeutics, LLC Protein kinase regulators
MX2019005588A (es) 2016-11-28 2019-10-15 Ptc Therapeutics Inc Metodos para modular corte y empalme de arn.
JP2020506904A (ja) 2017-01-27 2020-03-05 シグナルアールエックス ファーマシューティカルズ，インコーポレイテッド キナーゼ、ブロモドメイン及びチェックポイント阻害剤としてのチエノピラノン及びフラノピラノン
CA3066224A1 (en) 2017-06-05 2018-12-13 Ptc Therapeutics Inc. Compounds for treating huntington's disease
KR20200017476A (ko) 2017-06-14 2020-02-18 피티씨 테라퓨틱스, 인크. Rna 스플라이싱의 변경 방법
MX2019015580A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
US11382918B2 (en) 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
JP7399870B2 (ja) 2018-03-27 2023-12-18 ピーティーシー セラピューティクス， インコーポレイテッド ハンチントン病を処置するための化合物
KR20210038845A (ko) 2018-06-27 2021-04-08 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료를 위한 헤테로아릴 화합물
HUE068060T2 (hu) 2018-06-27 2024-12-28 Ptc Therapeutics Inc Heterociklikus és heteroaril vegyületek Huntington-kór kezelésére
US11685746B2 (en) 2018-06-27 2023-06-27 Ptc Therapeutics, Inc. Heteroaryl compounds for treating Huntington's disease
CN109748914B (zh) * 2018-12-29 2021-05-25 上海珂臻医药科技有限公司 吡啶并嘧啶类化合物及其应用
EP3759074B1 (en) 2019-05-15 2025-01-01 AlonBio Ltd. Small molecules for treating cancer, inhibiting chemokine activity and/or inducing cell death
AR121719A1 (es) 2020-04-03 2022-06-29 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
CN111533721B (zh) * 2020-05-15 2022-04-26 浙江大学 苯并吡喃酮或喹啉酮类化合物及其应用
WO2021247859A1 (en) * 2020-06-03 2021-12-09 Yumanity Therapeutics, Inc. Pyridopyrimidines and methods of their use
US20240166617A1 (en) * 2021-02-01 2024-05-23 Geode Therapeutics Inc. Phosphoinositide 3 kinase beta inhibitors and compositions and methods thereof
TW202309003A (zh) 2021-05-03 2023-03-01 美商佩特拉製藥公司 用於治療疾病之磷酸肌醇3-激酶(pi3k)異位色烯酮抑制劑
KR20240014065A (ko) 2021-05-27 2024-01-31 페트라 파마 코포레이션 암의 치료를 위한 포스포이노시티드 3-키나제 (pi3k)의 알로스테릭 크로메논 억제제
TW202329930A (zh) 2021-09-30 2023-08-01 美商佩特拉製藥公司 用於治療疾病之磷酸肌醇3-激酶(pi3k)之異位色烯酮抑制劑
US20250084048A1 (en) * 2021-10-07 2025-03-13 Relay Therapeutics, Inc. Pi3k-alpha inhibitors and methods of use thereof
WO2025136936A1 (en) * 2023-12-19 2025-06-26 Merck Sharp & Dohme Llc Agonists of trem2 activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS604170A (ja) * 1983-06-21 1985-01-10 Nippon Shinyaku Co Ltd キノロン誘導体
JPH04502322A (ja) 1988-12-21 1992-04-23 ジ・アップジョン・カンパニー 抗アテローム性動脈硬化症性および抗血栓性１―ベンゾピラン―４―オン類および２―アミノ―１，３―ベンゾオキサジン―４―オン類
US5703075A (en) * 1988-12-21 1997-12-30 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
CA2081577A1 (en) * 1990-06-20 1991-12-21 Ronald B. Gammill Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1, 3-benzoxazine-4-ones

Also Published As

Publication number Publication date
CY1108023T1 (el) 2013-09-04
AU3042601A (en) 2001-07-31
CN1891699A (zh) 2007-01-10
WO2001053266A1 (en) 2001-07-26
AU2001230426B2 (en) 2005-12-01
US20080206312A1 (en) 2008-08-28
EP1857443A2 (en) 2007-11-21
US20050085471A1 (en) 2005-04-21
US20030216389A1 (en) 2003-11-20
EP1857443A3 (en) 2007-12-26
DE60128655D1 (de) 2007-07-12
NZ520300A (en) 2004-05-28
CA2398163A1 (en) 2001-07-26
EP1857443B1 (en) 2012-03-28
AU2001230426C1 (en) 2006-06-22
HK1051187A1 (en) 2003-07-25
ATE551325T1 (de) 2012-04-15
PT1257537E (pt) 2007-08-03
DK1257537T3 (da) 2007-10-01
ES2286093T3 (es) 2007-12-01
JP4820518B2 (ja) 2011-11-24
CA2398163C (en) 2011-02-22
US7405211B2 (en) 2008-07-29
US6977255B2 (en) 2005-12-20
EP1257537A1 (en) 2002-11-20
DE60128655T2 (de) 2008-02-07
CN1891693A (zh) 2007-01-10
US7572791B2 (en) 2009-08-11
HK1115378A1 (en) 2008-11-28
CN1418195A (zh) 2003-05-14
EP1257537A4 (en) 2003-04-23
EP1257537B1 (en) 2007-05-30
US20080312233A1 (en) 2008-12-18
ATE363471T1 (de) 2007-06-15
JP2003530318A (ja) 2003-10-14

Similar Documents

Publication Publication Date Title
CN1263743C (zh) 用于治疗的吗啉代基取代的化合物
JP6026441B2 (ja) キナーゼ阻害剤としてのアミノキノリン
JP6212678B1 (ja) 置換された多環性ピリドン誘導体の製造方法およびその結晶
EP2707361B1 (en) Fused heterocyclic compounds as sodium channel modulators
CN1283626C (zh) 取代苯衍生物或其盐
CN1247567C (zh) 2－氨基－3－烷基嘧啶酮衍生物作为GSK3β抑制剂
JP4917041B2 (ja) タンパク質キナーゼ阻害剤としての化合物および組成物
JP5178681B2 (ja) 新規ピリミジンアミド誘導体およびその使用
CN1281590C (zh) 具有抑制血管生成活性的六员氨基酰胺类衍生物
JP6258331B2 (ja) キナーゼ阻害剤としてのアミノ−キノリン
US8492394B2 (en) (3-aryl-piperazin-1-yl), (2-aryl-morpholin-4-yl) and (2-aryl-thiomorpholin-4-yl) derivatives of 6,7-dialkoxy-quinazoline, 6,7-dialkoxyphtalazine and 6,7-dialkoxyisoquinoline as PDE10A enzyme inhibitors
TWI746525B (zh) 磷脂酸肌醇３－激酶γ的新穎抑制劑
CN1863774A (zh) 用作蛋白激酶抑制剂的化合物和组合物
CN1037898A (zh) 芳族及杂环甲酰胺衍生物抗肿瘤剂的制备
TWI295670B (en) Vanilloid receptor ligands and their use in treatments
JP2009530233A (ja) Ｐｉ−３キナーゼインヒビターおよびそれらの使用方法
JP2020526543A (ja) ロイシンリッチリピートキナーゼ２の阻害剤
JP2013533316A (ja) キナーゼ阻害剤としてのキノリルアミン
CN1127498C (zh) 吡啶衍生物、制备吡啶衍生物的方法及其中间体
CN1726213A (zh) 作为腺苷a3受体配体的咪唑并喹啉衍生物
CN1750824A (zh) 用于治疗局部缺血性损伤的4－[(2,4－二氯－5－甲氧苯基)氨基]－6－烷氧基－3－氰基喹琳类
CN101039943A (zh) 作为抗癌剂的新型吖吲哚噻唑啉酮
JP2010524885A (ja) がん治療剤としてのナフタレンカルボン酸アミドのエーテル
CN1688575A (zh) 抑制磷酸肌醇3－激酶β
CN1184221C (zh) 有7－(7－氨甲基－5－氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: ASTRAZENECA AB

Free format text: FORMER OWNER: KIENACIA CO. LTD.

Effective date: 20070810

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20070810

Address after: Swedish Sodertalje

Patentee after: Astrazeneca AB

Address before: Vitoria, Australia

Patentee before: Kienacia Co., Ltd.

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060712

Termination date: 20130124

CF01 Termination of patent right due to non-payment of annual fee