CN1262556C - 特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用 - Google Patents

特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用 Download PDF

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Publication number
CN1262556C
CN1262556C CNB988032597A CN98803259A CN1262556C CN 1262556 C CN1262556 C CN 1262556C CN B988032597 A CNB988032597 A CN B988032597A CN 98803259 A CN98803259 A CN 98803259A CN 1262556 C CN1262556 C CN 1262556C
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CN
China
Prior art keywords
uridine
tetraphosphate
compound
pharmaceutical composition
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988032597A
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English (en)
Chinese (zh)
Other versions
CN1292795A (zh
Inventor
W·彭德格斯特
B·R·耶扎
J·L·赖德奥特
S·M·西迪基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Inspire Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/797,472 external-priority patent/US5900407A/en
Priority claimed from US08/798,508 external-priority patent/US5837861A/en
Application filed by Inspire Pharmaceuticals Inc filed Critical Inspire Pharmaceuticals Inc
Publication of CN1292795A publication Critical patent/CN1292795A/zh
Application granted granted Critical
Publication of CN1262556C publication Critical patent/CN1262556C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CNB988032597A 1997-02-06 1998-02-06 特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用 Expired - Fee Related CN1262556C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/797,472 1997-02-06
US08/797,472 US5900407A (en) 1997-02-06 1997-02-06 Method of treating dry eye disease with uridine triphosphates and related compounds
US08/798,508 1997-02-10
US08/798,508 US5837861A (en) 1997-02-10 1997-02-10 Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency

Publications (2)

Publication Number Publication Date
CN1292795A CN1292795A (zh) 2001-04-25
CN1262556C true CN1262556C (zh) 2006-07-05

Family

ID=27121880

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988032597A Expired - Fee Related CN1262556C (zh) 1997-02-06 1998-02-06 特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用

Country Status (16)

Country Link
US (2) US6348589B1 (enExample)
EP (1) EP0981534B1 (enExample)
JP (1) JP4531867B2 (enExample)
KR (1) KR100606131B1 (enExample)
CN (1) CN1262556C (enExample)
AT (1) ATE325129T1 (enExample)
AU (1) AU738907C (enExample)
BR (1) BR9807169A (enExample)
CA (1) CA2279963C (enExample)
DE (1) DE69834392T2 (enExample)
DK (1) DK0981534T3 (enExample)
ES (1) ES2264197T3 (enExample)
NO (1) NO326718B1 (enExample)
NZ (1) NZ337225A (enExample)
PT (1) PT981534E (enExample)
WO (1) WO1998034942A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106729718A (zh) * 2010-09-10 2017-05-31 参天制药株式会社 以组合p2y2受体激动剂和透明质酸或其盐为特征的干眼症治疗剂

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106729718A (zh) * 2010-09-10 2017-05-31 参天制药株式会社 以组合p2y2受体激动剂和透明质酸或其盐为特征的干眼症治疗剂

Also Published As

Publication number Publication date
NO326718B1 (no) 2009-02-02
KR100606131B1 (ko) 2006-07-31
AU6324298A (en) 1998-08-26
DK0981534T3 (da) 2006-09-04
EP0981534A2 (en) 2000-03-01
DE69834392D1 (de) 2006-06-08
US6348589B1 (en) 2002-02-19
WO1998034942A2 (en) 1998-08-13
AU738907C (en) 2002-05-16
KR20000070807A (ko) 2000-11-25
US20020082417A1 (en) 2002-06-27
NZ337225A (en) 2002-03-28
BR9807169A (pt) 2000-06-06
PT981534E (pt) 2006-09-29
WO1998034942A3 (en) 2000-01-06
JP4531867B2 (ja) 2010-08-25
EP0981534B1 (en) 2006-05-03
DE69834392T2 (de) 2007-02-08
JP2001526635A (ja) 2001-12-18
CN1292795A (zh) 2001-04-25
AU738907B2 (en) 2001-09-27
ATE325129T1 (de) 2006-06-15
NO993776L (no) 1999-10-06
NO993776D0 (no) 1999-08-04
CA2279963C (en) 2008-04-22
CA2279963A1 (en) 1998-08-13
US6977246B2 (en) 2005-12-20
ES2264197T3 (es) 2006-12-16

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