KR100606131B1 - 디뉴클레오티드 및 그의 용도 - Google Patents

디뉴클레오티드 및 그의 용도 Download PDF

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Publication number
KR100606131B1
KR100606131B1 KR1019997007070A KR19997007070A KR100606131B1 KR 100606131 B1 KR100606131 B1 KR 100606131B1 KR 1019997007070 A KR1019997007070 A KR 1019997007070A KR 19997007070 A KR19997007070 A KR 19997007070A KR 100606131 B1 KR100606131 B1 KR 100606131B1
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KR
South Korea
Prior art keywords
uridine
tetraphosphate
pharmaceutically acceptable
compound
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019997007070A
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English (en)
Korean (ko)
Other versions
KR20000070807A (ko
Inventor
펜더개스트윌리엄
예륵사벤자민알.
리드아웃쟈넷엘.
싯디퀴수하이브엠.
Original Assignee
인스파이어 파마슈티컬스 인코퍼레이티드
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Priority claimed from US08/797,472 external-priority patent/US5900407A/en
Priority claimed from US08/798,508 external-priority patent/US5837861A/en
Application filed by 인스파이어 파마슈티컬스 인코퍼레이티드 filed Critical 인스파이어 파마슈티컬스 인코퍼레이티드
Publication of KR20000070807A publication Critical patent/KR20000070807A/ko
Application granted granted Critical
Publication of KR100606131B1 publication Critical patent/KR100606131B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1019997007070A 1997-02-06 1998-02-06 디뉴클레오티드 및 그의 용도 Expired - Fee Related KR100606131B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08/797,472 US5900407A (en) 1997-02-06 1997-02-06 Method of treating dry eye disease with uridine triphosphates and related compounds
US8/797,472 1997-02-06
US08/797,472 1997-02-06
US08/798,508 US5837861A (en) 1997-02-10 1997-02-10 Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency
US08/798,508 1997-02-10
US8/798,508 1997-02-10
PCT/US1998/002702 WO1998034942A2 (en) 1997-02-06 1998-02-06 Dinucleotides and their use

Publications (2)

Publication Number Publication Date
KR20000070807A KR20000070807A (ko) 2000-11-25
KR100606131B1 true KR100606131B1 (ko) 2006-07-31

Family

ID=27121880

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997007070A Expired - Fee Related KR100606131B1 (ko) 1997-02-06 1998-02-06 디뉴클레오티드 및 그의 용도

Country Status (16)

Country Link
US (2) US6348589B1 (enExample)
EP (1) EP0981534B1 (enExample)
JP (1) JP4531867B2 (enExample)
KR (1) KR100606131B1 (enExample)
CN (1) CN1262556C (enExample)
AT (1) ATE325129T1 (enExample)
AU (1) AU738907C (enExample)
BR (1) BR9807169A (enExample)
CA (1) CA2279963C (enExample)
DE (1) DE69834392T2 (enExample)
DK (1) DK0981534T3 (enExample)
ES (1) ES2264197T3 (enExample)
NO (1) NO326718B1 (enExample)
NZ (1) NZ337225A (enExample)
PT (1) PT981534E (enExample)
WO (1) WO1998034942A2 (enExample)

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US7223744B2 (en) * 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US6596725B2 (en) 1997-02-10 2003-07-22 Inspire Pharmaceuticals, Inc. Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema
US6462028B2 (en) 1997-07-25 2002-10-08 Inspire Pharmaceuticals, Inc. Method of promoting cervical and vaginal secretions
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WO1996040059A1 (en) * 1995-06-07 1996-12-19 The University Of North Carolina At Chapel Hill Dinucleotides useful for the treatment of lung disease

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WO1996040059A1 (en) * 1995-06-07 1996-12-19 The University Of North Carolina At Chapel Hill Dinucleotides useful for the treatment of lung disease

Also Published As

Publication number Publication date
NZ337225A (en) 2002-03-28
WO1998034942A3 (en) 2000-01-06
ATE325129T1 (de) 2006-06-15
AU6324298A (en) 1998-08-26
KR20000070807A (ko) 2000-11-25
US6977246B2 (en) 2005-12-20
CN1262556C (zh) 2006-07-05
CA2279963A1 (en) 1998-08-13
DE69834392T2 (de) 2007-02-08
JP2001526635A (ja) 2001-12-18
AU738907B2 (en) 2001-09-27
AU738907C (en) 2002-05-16
DK0981534T3 (da) 2006-09-04
US6348589B1 (en) 2002-02-19
BR9807169A (pt) 2000-06-06
US20020082417A1 (en) 2002-06-27
CA2279963C (en) 2008-04-22
JP4531867B2 (ja) 2010-08-25
EP0981534B1 (en) 2006-05-03
NO993776L (no) 1999-10-06
CN1292795A (zh) 2001-04-25
NO993776D0 (no) 1999-08-04
WO1998034942A2 (en) 1998-08-13
NO326718B1 (no) 2009-02-02
PT981534E (pt) 2006-09-29
DE69834392D1 (de) 2006-06-08
ES2264197T3 (es) 2006-12-16
EP0981534A2 (en) 2000-03-01

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