JP4531867B2 - 一定のジヌクレオチドおよび粘膜繊毛クリアランスおよび繊毛運動頻度のモジュレーターとしてのそれらの使用 - Google Patents
一定のジヌクレオチドおよび粘膜繊毛クリアランスおよび繊毛運動頻度のモジュレーターとしてのそれらの使用 Download PDFInfo
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- JP4531867B2 JP4531867B2 JP53505598A JP53505598A JP4531867B2 JP 4531867 B2 JP4531867 B2 JP 4531867B2 JP 53505598 A JP53505598 A JP 53505598A JP 53505598 A JP53505598 A JP 53505598A JP 4531867 B2 JP4531867 B2 JP 4531867B2
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- Prior art keywords
- uridine
- pharmaceutically acceptable
- tetraphosphate
- pharmaceutical composition
- treatment
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- RUAYLFCHPJYFJL-HVVPPSBSSA-N n,n'-dicyclohexylmorpholine-4-carboximidamide;[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-morpholin-4-ylphosphinic acid Chemical compound C1CCCCC1NC(N1CCOCC1)=NC1CCCCC1.C([C@@H]1[C@H]([C@H]([C@@H](O1)N1C(NC(=O)C=C1)=O)O)O)OP(O)(=O)N1CCOCC1 RUAYLFCHPJYFJL-HVVPPSBSSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/797,472 US5900407A (en) | 1997-02-06 | 1997-02-06 | Method of treating dry eye disease with uridine triphosphates and related compounds |
| US08/797,472 | 1997-02-06 | ||
| US08/798,508 US5837861A (en) | 1997-02-10 | 1997-02-10 | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
| US08/798,508 | 1997-02-10 | ||
| PCT/US1998/002702 WO1998034942A2 (en) | 1997-02-06 | 1998-02-06 | Dinucleotides and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001526635A JP2001526635A (ja) | 2001-12-18 |
| JP2001526635A5 JP2001526635A5 (enExample) | 2005-10-06 |
| JP4531867B2 true JP4531867B2 (ja) | 2010-08-25 |
Family
ID=27121880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53505598A Expired - Fee Related JP4531867B2 (ja) | 1997-02-06 | 1998-02-06 | 一定のジヌクレオチドおよび粘膜繊毛クリアランスおよび繊毛運動頻度のモジュレーターとしてのそれらの使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6348589B1 (enExample) |
| EP (1) | EP0981534B1 (enExample) |
| JP (1) | JP4531867B2 (enExample) |
| KR (1) | KR100606131B1 (enExample) |
| CN (1) | CN1262556C (enExample) |
| AT (1) | ATE325129T1 (enExample) |
| AU (1) | AU738907C (enExample) |
| BR (1) | BR9807169A (enExample) |
| CA (1) | CA2279963C (enExample) |
| DE (1) | DE69834392T2 (enExample) |
| DK (1) | DK0981534T3 (enExample) |
| ES (1) | ES2264197T3 (enExample) |
| NO (1) | NO326718B1 (enExample) |
| NZ (1) | NZ337225A (enExample) |
| PT (1) | PT981534E (enExample) |
| WO (1) | WO1998034942A2 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673779B2 (en) * | 1996-03-27 | 2004-01-06 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with dinucleoside polyphosphate compounds or UTP analogues |
| US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| DE69834392T2 (de) | 1997-02-06 | 2007-02-08 | Inspire Pharmaceuticals, Inc. | Dinukleotide und ihre verwendungen |
| US6818629B2 (en) * | 1997-02-10 | 2004-11-16 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate |
| US6596725B2 (en) | 1997-02-10 | 2003-07-22 | Inspire Pharmaceuticals, Inc. | Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema |
| US7223744B2 (en) * | 1997-02-10 | 2007-05-29 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof |
| US7078391B2 (en) * | 1997-02-10 | 2006-07-18 | Inspire Pharmaceuticals, Inc. | Method of treating edematous retinal disorders |
| US6462028B2 (en) | 1997-07-25 | 2002-10-08 | Inspire Pharmaceuticals, Inc. | Method of promoting cervical and vaginal secretions |
| US6872710B2 (en) | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
| US6548658B2 (en) * | 1997-07-25 | 2003-04-15 | Inspire Pharmaceuticals, Inc. | Di-(uridine 5′)-tetraphosphate and salts thereof |
| EP1012154B1 (en) * | 1997-07-25 | 2004-03-17 | Inspire Pharmaceuticals, Inc. | Salts of di(uridine 5'-tetraphosphate), method for preparation and uses thereof |
| TW593331B (en) | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
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- 1998-02-06 KR KR1019997007070A patent/KR100606131B1/ko not_active Expired - Fee Related
- 1998-02-06 DK DK98907435T patent/DK0981534T3/da active
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|---|---|
| NO993776D0 (no) | 1999-08-04 |
| NO326718B1 (no) | 2009-02-02 |
| CA2279963A1 (en) | 1998-08-13 |
| AU738907B2 (en) | 2001-09-27 |
| US6977246B2 (en) | 2005-12-20 |
| ES2264197T3 (es) | 2006-12-16 |
| WO1998034942A3 (en) | 2000-01-06 |
| PT981534E (pt) | 2006-09-29 |
| AU738907C (en) | 2002-05-16 |
| EP0981534A2 (en) | 2000-03-01 |
| JP2001526635A (ja) | 2001-12-18 |
| DK0981534T3 (da) | 2006-09-04 |
| DE69834392D1 (de) | 2006-06-08 |
| BR9807169A (pt) | 2000-06-06 |
| WO1998034942A2 (en) | 1998-08-13 |
| CA2279963C (en) | 2008-04-22 |
| KR20000070807A (ko) | 2000-11-25 |
| US20020082417A1 (en) | 2002-06-27 |
| KR100606131B1 (ko) | 2006-07-31 |
| EP0981534B1 (en) | 2006-05-03 |
| NO993776L (no) | 1999-10-06 |
| CN1262556C (zh) | 2006-07-05 |
| CN1292795A (zh) | 2001-04-25 |
| US6348589B1 (en) | 2002-02-19 |
| NZ337225A (en) | 2002-03-28 |
| ATE325129T1 (de) | 2006-06-15 |
| AU6324298A (en) | 1998-08-26 |
| DE69834392T2 (de) | 2007-02-08 |
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