JP2001526635A5 - - Google Patents

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Publication number
JP2001526635A5
JP2001526635A5 JP1998535055A JP53505598A JP2001526635A5 JP 2001526635 A5 JP2001526635 A5 JP 2001526635A5 JP 1998535055 A JP1998535055 A JP 1998535055A JP 53505598 A JP53505598 A JP 53505598A JP 2001526635 A5 JP2001526635 A5 JP 2001526635A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1998535055A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001526635A (ja
JP4531867B2 (ja
Filing date
Publication date
Priority claimed from US08/797,472 external-priority patent/US5900407A/en
Priority claimed from US08/798,508 external-priority patent/US5837861A/en
Application filed filed Critical
Priority claimed from PCT/US1998/002702 external-priority patent/WO1998034942A2/en
Publication of JP2001526635A publication Critical patent/JP2001526635A/ja
Publication of JP2001526635A5 publication Critical patent/JP2001526635A5/ja
Application granted granted Critical
Publication of JP4531867B2 publication Critical patent/JP4531867B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP53505598A 1997-02-06 1998-02-06 一定のジヌクレオチドおよび粘膜繊毛クリアランスおよび繊毛運動頻度のモジュレーターとしてのそれらの使用 Expired - Fee Related JP4531867B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/797,472 US5900407A (en) 1997-02-06 1997-02-06 Method of treating dry eye disease with uridine triphosphates and related compounds
US08/797,472 1997-02-06
US08/798,508 US5837861A (en) 1997-02-10 1997-02-10 Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency
US08/798,508 1997-02-10
PCT/US1998/002702 WO1998034942A2 (en) 1997-02-06 1998-02-06 Dinucleotides and their use

Publications (3)

Publication Number Publication Date
JP2001526635A JP2001526635A (ja) 2001-12-18
JP2001526635A5 true JP2001526635A5 (enExample) 2005-10-06
JP4531867B2 JP4531867B2 (ja) 2010-08-25

Family

ID=27121880

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53505598A Expired - Fee Related JP4531867B2 (ja) 1997-02-06 1998-02-06 一定のジヌクレオチドおよび粘膜繊毛クリアランスおよび繊毛運動頻度のモジュレーターとしてのそれらの使用

Country Status (16)

Country Link
US (2) US6348589B1 (enExample)
EP (1) EP0981534B1 (enExample)
JP (1) JP4531867B2 (enExample)
KR (1) KR100606131B1 (enExample)
CN (1) CN1262556C (enExample)
AT (1) ATE325129T1 (enExample)
AU (1) AU738907C (enExample)
BR (1) BR9807169A (enExample)
CA (1) CA2279963C (enExample)
DE (1) DE69834392T2 (enExample)
DK (1) DK0981534T3 (enExample)
ES (1) ES2264197T3 (enExample)
NO (1) NO326718B1 (enExample)
NZ (1) NZ337225A (enExample)
PT (1) PT981534E (enExample)
WO (1) WO1998034942A2 (enExample)

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US6319908B1 (en) 1996-07-03 2001-11-20 Inspire Pharmaceuticals, Inc. Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof
US5763447C1 (en) 1996-07-23 2002-05-07 Inspire Pharmaceuticals Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds
DK0981534T3 (da) 1997-02-06 2006-09-04 Inspire Pharmaceuticals Inc Dinukleotider og deres anvendelser
US7078391B2 (en) * 1997-02-10 2006-07-18 Inspire Pharmaceuticals, Inc. Method of treating edematous retinal disorders
US6818629B2 (en) * 1997-02-10 2004-11-16 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
US7223744B2 (en) * 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US6596725B2 (en) 1997-02-10 2003-07-22 Inspire Pharmaceuticals, Inc. Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema
US6462028B2 (en) 1997-07-25 2002-10-08 Inspire Pharmaceuticals, Inc. Method of promoting cervical and vaginal secretions
US6872710B2 (en) * 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
US6548658B2 (en) * 1997-07-25 2003-04-15 Inspire Pharmaceuticals, Inc. Di-(uridine 5′)-tetraphosphate and salts thereof
TW593331B (en) 1997-07-25 2004-06-21 Inspire Pharmaceuticals Inc Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
DE69822482T2 (de) * 1997-07-25 2005-03-03 Inspire Pharmaceuticals, Inc. Salze von di(uridine 5'-tetraphosphate), verfahren zur herstellung und verwendungen davon
EP1011688B1 (en) * 1997-08-29 2005-02-02 The University of North Carolina at Chapel Hill Use of uridine 5'-diphosphate and analogs thereof for the treatment of lung diseases
ATE232733T1 (de) * 1998-05-22 2003-03-15 Inspire Pharmaceuticals Inc Therapeutische dinucleotide und deren derivate
JP2002533110A (ja) * 1998-12-23 2002-10-08 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル Gタンパク質共役レセプターを使用した目的とする遺伝子の導入
BR0008498A (pt) 1999-02-26 2002-02-05 Inspire Pharmaceuticals Inc Método de promoção de hidratação de mucosas com certos difosfatos de uridina, adenina e citidina e seus análogos
DE60006814T2 (de) 1999-06-30 2004-05-19 Yamasa Corp., Choshi Dinucleotid-kristalle
AU6551800A (en) * 1999-08-17 2001-03-13 Adani, Alexander Dinucleoside 5',5'-tetraphosphates as inhibitors of viral reverse transcriptasesand viruses
EP1261323A2 (en) * 1999-12-22 2002-12-04 Inspire Pharmaceuticals, Inc. Method of treating gastrointestinal tract disease with purinergic receptor agonists
RU2161982C1 (ru) * 2000-01-20 2001-01-20 Общество с ограниченной ответственностью "Клиника Института биорегуляции и геронтологии" Тетрапептид, стимулирующий функцию сетчатой оболочки глаза, фармакологическое средство на его основе и способ его применения
US6864243B1 (en) * 2000-05-12 2005-03-08 Inspire Pharmaceuticals, Inc. Method for treating retinal degeneration with purinergic receptor agonists
BR0111297A (pt) * 2000-05-30 2004-01-06 Santen Pharmaceutical Co Ltd Promotor de migração epitelial corneana
US7115585B2 (en) * 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
US6555675B2 (en) * 2000-08-21 2003-04-29 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists
US7132408B2 (en) * 2000-08-21 2006-11-07 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7452870B2 (en) * 2000-08-21 2008-11-18 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with P2Y12 receptor antagonist compound
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US20040266723A1 (en) * 2000-12-15 2004-12-30 Otto Michael J. Antiviral agents for treatment of Flaviviridae infections
EP1368366A1 (en) * 2001-02-07 2003-12-10 Celltech R & D Limited Non-natural nucleotides and dinucleotides
AR034635A1 (es) 2001-06-25 2004-03-03 Inspire Pharmaceuticals Inc Lubricacion de las articulaciones con agonistas del receptor purinergico p2y
US20050009777A1 (en) * 2001-07-25 2005-01-13 Mack Stephen Robert Non-natural carbon-linked nucleotides and dinucleotides
US20030109488A1 (en) * 2001-10-11 2003-06-12 Alcon, Inc. Methods for treating dry eye
CN1612739A (zh) * 2001-11-06 2005-05-04 印斯拜尔药品股份有限公司 治疗或预防炎性疾病的方法
US7084128B2 (en) * 2002-01-18 2006-08-01 Inspire Pharmaceuticals, Inc. Method for reducing intraocular pressure
JP2006505585A (ja) * 2002-10-18 2006-02-16 モリケム メディシンズ, インコーポレイテッド ランチビオティクスで眼乾燥症を処置する方法
US6984628B2 (en) * 2003-07-15 2006-01-10 Allergan, Inc. Ophthalmic compositions comprising trefoil factor family peptides
WO2005107787A1 (en) * 2004-05-06 2005-11-17 Molichem Medicines, Inc. Treatment of membrane-associated diseases and disorders using lantibiotic containing compositions
US7479481B2 (en) * 2004-05-06 2009-01-20 Molichem Medicines, Inc. Treatment of ocular diseases and disorders using lantibiotic compositions
GB0417886D0 (en) * 2004-08-11 2004-09-15 Univ Cardiff Method and means for enhanced pulmonary delivery
GB0502250D0 (en) * 2005-02-03 2005-03-09 Ic Vec Ltd Use
US7368439B2 (en) * 2005-06-15 2008-05-06 Bar - Ilan University Dinucleoside poly(borano)phosphate derivatives and uses thereof
US7851456B2 (en) * 2005-06-29 2010-12-14 Inspire Pharmaceuticals, Inc. P2Y6 receptor agonists for treating lung diseases
EP1959968A2 (en) 2005-12-06 2008-08-27 P2-Science APS Modulation of the p2y2 receptor pathway
US20070249556A1 (en) * 2006-04-21 2007-10-25 Brubaker Kurt E Method of treating inflammation
EP2045257B1 (en) * 2006-07-26 2016-08-17 Yamasa Corporation Process for producing di(pyrimidine nucleoside 5'-)polyphosphate
EP2049665A2 (en) * 2006-07-28 2009-04-22 Applera Corporation Dinucleotide mrna cap analogs
AU2008310734B2 (en) 2007-10-10 2014-06-05 Parion Sciences, Inc. Delivering osmolytes by nasal cannula
WO2010048341A1 (en) * 2008-10-22 2010-04-29 Inspire Pharmaceuticals, Inc. Method for treating cystic fibrosis
US9067964B2 (en) 2008-12-18 2015-06-30 Oligomer Sciences Ab Complex and method for enhancing nuclear delivery
US9011909B2 (en) 2010-09-03 2015-04-21 Wisconsin Pharmacal Company, Llc Prebiotic suppositories
EP2614838B1 (en) 2010-09-10 2016-04-20 Santen Pharmaceutical Co., Ltd. Diquafosol and hyaluronic acid or salts thereof for the treatment of dry eye
CN103732213A (zh) 2011-06-07 2014-04-16 帕里昂科学公司 治疗方法
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
ES2702575T3 (es) 2012-03-26 2019-03-04 Santen Pharmaceutical Co Ltd Solución oftálmica que comprende diquafosol
EP3366680B1 (en) 2012-05-29 2020-05-13 Parion Sciences, Inc. Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
RU2015129065A (ru) 2012-12-17 2017-01-25 Пэрион Сайенсиз, Инк. Производные хлор-пиразинкарбоксамида, обладающие активностью блокирования эпителиальных натриевых каналов
ES2674665T3 (es) 2012-12-17 2018-07-03 Parion Sciences, Inc. Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida
CN104995178B (zh) 2012-12-17 2018-06-26 帕里昂科学公司 3,5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物
WO2016014927A2 (en) 2014-07-24 2016-01-28 W.R. Grace & Co.-Conn. Crystalline form of nicotinamide riboside
CN107428791B (zh) 2015-03-09 2024-05-28 格雷斯公司 烟酰胺核苷的结晶形式
US20180125876A1 (en) 2015-05-20 2018-05-10 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and Pharmaceutical Composition for Modulation Polarization and Activation of Macrophages
WO2019126482A1 (en) 2017-12-22 2019-06-27 Elysium Health, Inc. Crystalline forms of nicotinamide riboside chloride
WO2021245107A2 (en) 2020-06-02 2021-12-09 Institut Gustave Roussy Modulators of purinergic receptors and related immune checkpoint for treating acute respiratory distress syndrom
EP3919062A1 (en) 2020-06-02 2021-12-08 Institut Gustave-Roussy Modulators of purinergic receptors and related immune checkpoint for treating acute respiratory distress syndrom

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US4855304A (en) 1985-01-10 1989-08-08 Repligen Corporation Dinucleoside pyrophosphates and pyrophosphate homologs as plant antivirals
US5049550A (en) 1987-11-05 1991-09-17 Worcester Foundation For Experimental Biology Diadenosine 5', 5'"-p1, p4,-tetraphosphate analogs as antithrombotic agents
US5292498A (en) * 1991-06-19 1994-03-08 The University Of North Carolina At Chapel Hill Method of treating lung disease with uridine triphosphates
AU688552B2 (en) * 1994-07-15 1998-03-12 Biosearch Italia S.P.A. Dinucleoside-5',5'-pyrophosphates
US5635160A (en) 1995-06-07 1997-06-03 The University Of North Carolina At Chapel Hill Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions
US5837861A (en) * 1997-02-10 1998-11-17 Inspire Pharmaceuticals, Inc. Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency
US5681823A (en) 1996-05-02 1997-10-28 Prp Inc. P1, P4 -dithio-P2 -P3 -monochloromethylene 5', 5'"-diadenosine P1, P4 -tetraphosphate as antithrombotic agent
US5789391A (en) * 1996-07-03 1998-08-04 Inspire Pharmaceuticals, Inc. Method of treating sinusitis with uridine triphosphates and related compounds
US5763447C1 (en) 1996-07-23 2002-05-07 Inspire Pharmaceuticals Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds
JP4118958B2 (ja) 1996-10-09 2008-07-16 ファーマセット,リミティド テトラホスホネート二環式トリス無水物
DK0981534T3 (da) 1997-02-06 2006-09-04 Inspire Pharmaceuticals Inc Dinukleotider og deres anvendelser

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