CN1253588A - 在植物中合成长链多不饱和脂肪酸的方法和组合物 - Google Patents

在植物中合成长链多不饱和脂肪酸的方法和组合物 Download PDF

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Publication number
CN1253588A
CN1253588A CN98804091A CN98804091A CN1253588A CN 1253588 A CN1253588 A CN 1253588A CN 98804091 A CN98804091 A CN 98804091A CN 98804091 A CN98804091 A CN 98804091A CN 1253588 A CN1253588 A CN 1253588A
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China
Prior art keywords
seq
dehydrogenase
acid
fatty acid
sequence
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Pending
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CN98804091A
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English (en)
Chinese (zh)
Inventor
D·克努特宗
P·穆克尔吉
Y·S·黄
J·图尔蒙德
S·乔德哈赖
A·E·Y·勒安纳德
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Abbott Laboratories
Monsanto Co
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Abbott Laboratories
Calgene LLC
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Filing date
Publication date
Priority claimed from US08/834,033 external-priority patent/US6075183A/en
Priority claimed from US08/834,655 external-priority patent/US5968809A/en
Priority claimed from US08/833,610 external-priority patent/US5972664A/en
Priority claimed from US08/956,985 external-priority patent/US6051754A/en
Application filed by Abbott Laboratories, Calgene LLC filed Critical Abbott Laboratories
Publication of CN1253588A publication Critical patent/CN1253588A/zh
Pending legal-status Critical Current

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    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
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    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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CN98804091A 1997-04-11 1998-04-10 在植物中合成长链多不饱和脂肪酸的方法和组合物 Pending CN1253588A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US08/834,033 US6075183A (en) 1997-04-11 1997-04-11 Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
US08/834,655 US5968809A (en) 1997-04-11 1997-04-11 Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US08/833,610 US5972664A (en) 1997-04-11 1997-04-11 Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US08/834,033 1997-10-24
US08/956,985 1997-10-24
US08/834,655 1997-10-24
US08/956,985 US6051754A (en) 1997-04-11 1997-10-24 Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
US08/833,610 1997-10-24

Publications (1)

Publication Number Publication Date
CN1253588A true CN1253588A (zh) 2000-05-17

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CN98804091A Pending CN1253588A (zh) 1997-04-11 1998-04-10 在植物中合成长链多不饱和脂肪酸的方法和组合物

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EP (2) EP0996732B1 (enExample)
JP (1) JP4087460B2 (enExample)
CN (1) CN1253588A (enExample)
AT (1) ATE297994T1 (enExample)
AU (1) AU720677B2 (enExample)
BG (1) BG103798A (enExample)
BR (1) BR9808506A (enExample)
CA (1) CA2285939C (enExample)
DE (1) DE69830587T2 (enExample)
DK (1) DK0996732T3 (enExample)
ES (2) ES2403154T3 (enExample)
HU (1) HUP0001517A3 (enExample)
IL (1) IL132148A0 (enExample)
IN (1) IN1998KO00636A (enExample)
NO (1) NO994926L (enExample)
NZ (1) NZ337459A (enExample)
PL (1) PL336077A1 (enExample)
PT (2) PT1598422E (enExample)
SK (1) SK139999A3 (enExample)
TR (1) TR199902474T2 (enExample)
WO (1) WO1998046764A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
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CN1302110C (zh) * 2005-06-23 2007-02-28 复旦大学 水稻Osfad8编码序列及其应用
CN100339481C (zh) * 2005-03-17 2007-09-26 东北师范大学 应用基因沉默技术提高大豆和花生的种子油酸含量的方法
US7893321B2 (en) 2005-05-23 2011-02-22 Arcadia Biosciences, Inc. Safflower with elevated gamma-linolenic acid
CN104839353A (zh) * 2015-04-30 2015-08-19 安庆市顺民粮油贸易有限公司 一种幼儿保健食用油及其制作方法
CN105400838A (zh) * 2015-12-30 2016-03-16 厦门金达威集团股份有限公司 一种生物酶催化制备磷脂型dha的方法
CN113957105A (zh) * 2008-11-18 2022-01-21 联邦科学技术研究组织 产生ω-3脂肪酸的酶和方法

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968809A (en) 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US6432684B1 (en) * 1997-04-11 2002-08-13 Abbott Laboratories Human desaturase gene and uses thereof
US6566583B1 (en) 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
GB9724783D0 (en) 1997-11-24 1998-01-21 Inst Arable Crops Research Novel polypeptides
AU763296B2 (en) * 1998-03-20 2003-07-17 E.I. Du Pont De Nemours And Company Limanthes oil genes
US6838594B1 (en) 1998-03-20 2005-01-04 E. I. Du Pont De Nemours And Company Limnanthes oil genes
EP1086236B1 (en) * 1998-06-12 2007-09-05 Calgene LLC Polyunsaturated fatty acids in plants
DE19836339B4 (de) 1998-08-11 2011-12-22 N.V. Nutricia Kohlenhydratmischung
AU1097900A (en) * 1998-10-05 2000-04-26 Abbott Laboratories Delta 6 and delta 12 desaturases and modified fatty acid biosynthesis and products produced therefrom
US8791327B2 (en) 1998-12-07 2014-07-29 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
US6825017B1 (en) 1998-12-07 2004-11-30 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
CA2791961A1 (en) * 1998-12-07 2000-06-15 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
US7217856B2 (en) 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7247461B2 (en) 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US8003772B2 (en) 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
US7271315B2 (en) 1999-01-14 2007-09-18 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7211418B2 (en) 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
IL146782A0 (en) 1999-06-07 2002-07-25 Basf Plant Science Gmbh 6-acetylenase and 6-desaturase from ceratodon purpureus
DE10030976A1 (de) 2000-06-30 2002-01-10 Basf Ag DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren
EP1190080A1 (de) * 1999-07-06 2002-03-27 BASF Plant Science GmbH $g(D)6-DESATURASEGENE EXPRIMIERENDE PFLANZEN UND PUFAS ENTHALTENDE ÖLE AUS DIESEN PFLANZEN UND EIN VERFAHREN ZUR HERSTELLUNG UNGESÄTTIGTER FETTSÄUREN
AU6091600A (en) * 1999-07-12 2001-01-30 Ohio University Mammalian cells expressing desaturases and elongases
AU781262B2 (en) * 1999-12-23 2005-05-12 Adisseo France S.A.S. Particulate vitamin composition
PL207026B1 (pl) * 2000-02-09 2010-10-29 Basf Ag Wyizolowany kwas nukleinowy, konstrukt genowy zawierający ten kwas, sekwencja aminokwasowa kodowana przez wyizolowaną sekwencję tego kwasu nukleinowego, wektor zawierający kwas nukleinowy lub konstrukt genowy, roślina transgeniczna lub mikroorganizm transgeniczny zawierający kwas nukleinowy, konstrukt genowy lub wektor, przeciwciało specyficznie wiążące się z polipeptydem kodowanym przez kwas nukleinowy, cząsteczka antysensownego kwasu nukleinowego oraz sposób wytwarzania wielonienasyconych kwasów tłuszczowych (PUFA)
ES2343106T3 (es) 2000-09-28 2010-07-23 BIORIGINAL FOOD & SCIENCE CORP. Fad4, fad5, fad5-2 y fad6, miembros de la familia de desaturasas de acidos grasos y usos de los mismos.
DE10102338A1 (de) * 2001-01-19 2002-07-25 Basf Plant Science Gmbh Verfahren zur Expression von Biosynthesegenen in pflanzlichen Samen unter Verwendung von neuen multiplen Expressionskonstrukten
US6635451B2 (en) * 2001-01-25 2003-10-21 Abbott Laboratories Desaturase genes and uses thereof
GB0107510D0 (en) 2001-03-26 2001-05-16 Univ Bristol New elongase gene and a process for the production of -9-polyunsaturated fatty acids
US7045683B2 (en) * 2001-05-04 2006-05-16 Abbott Laboratories Δ4-desaturase genes and uses thereof
US7211656B2 (en) † 2002-01-30 2007-05-01 Abbott Laboratories Desaturase genes, enzymes encoded thereby, and uses thereof
EP1472357B1 (de) 2002-01-30 2009-12-16 BASF Plant Science GmbH Verfahren zur herstellung mehrfach ungesättigter fettsäuren mittels eines neuen elongase-gens
GB2385852A (en) * 2002-02-27 2003-09-03 Rothamsted Ex Station Delta 6-desaturases from Primulaceae
DE10219203A1 (de) 2002-04-29 2003-11-13 Basf Plant Science Gmbh Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in Pflanzen
FR2844142B1 (fr) 2002-09-11 2007-08-17 Bayer Cropscience Sa Plantes transformees a biosynthese de prenylquinones amelioree
FR2848570B1 (fr) 2002-12-12 2005-04-01 Bayer Cropscience Sa Cassette d'expression codant pour une 5-enol pyruvylshikimate-3-phosphate synthase (epsps) et plantes tolerantes aux herbicides la contenant
BR0317304A (pt) 2002-12-19 2005-11-08 Univ Bristol Processo para a produção de compostos, sequência de ácido nucleico isolada, sequência de aminoácidos, construção gênica, vetor, e, organismo
US20040172682A1 (en) * 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
US8084074B2 (en) 2003-02-12 2011-12-27 E. I. Du Pont De Nemours And Company Production of very long chain polyunsaturated fatty acids in oil seed plants
ATE517984T1 (de) 2003-02-27 2011-08-15 Basf Plant Science Gmbh Verfahren zur herstellung mehrfach ungesättigter fettsäuren
EP3121269A1 (de) 2003-03-31 2017-01-25 University Of Bristol Neue pflanzliche acyltransferase spezifisch für langkettige mehrfach ungesättigte fettsäuren
JP4732333B2 (ja) 2003-04-08 2011-07-27 ビーエーエスエフ プラント サイエンス ゲーエムベーハー ミドリムシ（Ｅｕｇｌｅｎａｇｒａｃｉｌｉｓ）由来のΔ−４−デサチュラーゼを発現する植物およびＰＵＦＡ含有油
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
PT2172536T (pt) 2003-08-01 2016-08-17 Basf Plant Science Gmbh Processo para a produção de ácidos gordos poli-insaturados em organismos transgénicos
AU2004268196B2 (en) 2003-08-21 2010-03-04 Monsanto Technology Llc Fatty acid desaturases from primula
US20050132441A1 (en) 2003-11-12 2005-06-16 Damude Howard G. Delta15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast
WO2005059130A1 (ja) * 2003-12-17 2005-06-30 Suntory Limited アラキドン酸を含有する植物体およびその利用
CA2558726C (en) 2004-02-27 2017-11-07 Basf Plant Science Gmbh Method for producing unsaturated .omega.-3-fatty acids in transgenic organisms
CN1930277B (zh) 2004-02-27 2011-02-02 巴斯福植物科学有限公司 在转基因植物中产生多不饱和脂肪酸的方法
JP2007533310A (ja) 2004-04-16 2007-11-22 モンサント テクノロジー エルエルシー トウモロコシにおける脂肪酸デサチュラーゼの発現
PL1756280T3 (pl) * 2004-04-22 2015-04-30 Commw Scient Ind Res Org Synteza długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach rekombinowanych
ES2529572T3 (es) 2004-04-22 2015-02-23 Commonwealth Scientific And Industrial Research Organisation Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes
EP1597978A1 (en) 2004-05-17 2005-11-23 Nutricia N.V. Synergism of GOS and polyfructose
US20050266051A1 (en) * 2004-05-27 2005-12-01 The Procter & Gamble Company Pet food compositions and methods
AU2005250074B2 (en) 2004-06-04 2011-04-14 Fluxome Sciences A/S Metabolically engineered cells for the production of polyunsaturated fatty acids
US8252769B2 (en) 2004-06-22 2012-08-28 N. V. Nutricia Intestinal barrier integrity
US7550651B2 (en) 2004-06-25 2009-06-23 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
EP1634599A1 (en) 2004-08-20 2006-03-15 N.V. Nutricia Iimmune stimulatory infant nutrition
AU2006219823A1 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
DE102005013779A1 (de) 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
DE102005038036A1 (de) 2005-08-09 2007-02-15 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen
GB2431158A (en) 2005-10-13 2007-04-18 Rothamsted Res Ltd Process for the production of arachidonic and/or eicosapentaenoic acid
DE102005052551A1 (de) 2005-11-02 2007-05-16 Rothamsted Res Harpenden Verfahren zur Herstellung von y-Linolensäure und/oder Stearidonsäure in transgenen Brassicaceae und Linaceae
WO2007061742A1 (en) 2005-11-23 2007-05-31 E. I. Du Pont De Nemours And Company Delta-9 elongases and their use in making polyunsaturated fatty acids
GB0603160D0 (en) 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
MX340759B (es) 2006-03-15 2015-03-11 Dsm Ip Assets B V * Aceites de semillas vegetales que contienen ácidos grasos poli-insaturados.
US8629195B2 (en) 2006-04-08 2014-01-14 Bayer Materialscience Ag Production of polyurethane foams
US7943823B2 (en) 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7678560B2 (en) * 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
US7695950B2 (en) 2006-05-17 2010-04-13 E. I. Du Pont De Nemours And Company Δ5 desaturase and its use in making polyunsaturated fatty acids
CA2659993C (en) 2006-08-24 2016-01-05 Basf Plant Science Gmbh Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains
BRPI0716075A2 (pt) 2006-08-29 2013-08-06 Commw Scient Ind Res Org sÍntese de Ácidos graxos
WO2008040787A2 (de) 2006-10-06 2008-04-10 Basf Plant Science Gmbh Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen
CA2663768A1 (en) 2006-10-23 2008-05-29 E. I. Du Pont De Nemours And Company Delta-8 desaturases and their use in making polyunsaturated fatty acids
US8188338B2 (en) 2007-04-10 2012-05-29 E. I. Du Pont De Nemours And Company Delta-8 desaturases and their use in making polyunsaturated fatty acids
US8119860B2 (en) 2007-04-16 2012-02-21 E. I. Du Pont De Nemours And Company Delta-9 elongases and their use in making polyunsaturated fatty acids
US7943365B2 (en) * 2007-05-03 2011-05-17 E.I. Du Pont De Nemours And Company Δ-5 desaturases and their use in making polyunsaturated fatty acids
WO2009016208A2 (de) 2007-07-31 2009-02-05 Basf Plant Science Gmbh Elongasen und verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen
CA2708087A1 (en) 2007-12-14 2009-06-25 Bioriginal Food & Science Corp. Promoters from brassica napus for seed specific gene expression
EP2234475A1 (en) * 2007-12-20 2010-10-06 Dow Agrosciences LLC Low saturated-fat sunflower and associated methods
US8785727B2 (en) 2008-04-30 2014-07-22 Rothamsted Research Ltd. Desaturase and method for the production of polyunsaturated fatty acids in transgenic organisms
WO2010000708A2 (en) 2008-07-01 2010-01-07 Basf Plant Science Gmbh Promoters from brassica napus for seed specific gene expression
EP2331695B1 (en) 2008-08-26 2014-07-23 BASF Plant Science GmbH Nucleic acids encoding desaturases and modified plant oil
DE112009003708T5 (de) 2008-12-12 2012-09-13 Basf Plant Science Gmbh Desaturasen und Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenenOrganismen
AR074941A1 (es) 2009-01-07 2011-02-23 Bayer Cropscience Sa Plantas transplastomicas exentas de marcador de seleccion
ES2717102T3 (es) 2009-03-19 2019-06-19 Dsm Ip Assets Bv Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos
CA2760326A1 (en) 2009-05-13 2010-11-18 Basf Plant Science Company Gmbh Acyltransferases and uses thereof in fatty acid production
US11236351B2 (en) 2010-05-17 2022-02-01 Dow Agrosciences Llc Production of DHA and other LC PUFAs in plants
US9388437B2 (en) 2010-06-25 2016-07-12 Basf Plant Science Company Gmbh Acyltransferases and uses thereof in fatty acid production
AU2011293189B2 (en) 2010-08-26 2017-02-16 E. I. Du Pont De Nemours And Company Mutant HPGG motif and HDASH motif delta-5 desaturases and their use in making polyunsaturated fatty acids
TW201307553A (zh) * 2011-07-26 2013-02-16 Dow Agrosciences Llc 在植物中生產二十二碳六烯酸（ｄｈａ）及其他長鏈多元不飽和脂肪酸（ｌｃ－ｐｕｆａ）之技術
BR112014013098A2 (pt) * 2011-11-29 2017-06-13 Dignity Sciences Ltd composições compreendendo ácidos graxos que têm 20 carbonos e métodos de produção e uso dos mesmos
BR112014025265A2 (pt) 2012-04-12 2017-07-11 Rothamsted Res Ltd produção de ácidos graxos poli-insaturados ômega-3 de cadeia longa
HUE033766T2 (en) 2012-06-15 2018-01-29 Commw Scient Ind Res Org Production of long chain polyunsaturated fatty acids in plant cells
WO2013192007A1 (en) 2012-06-19 2013-12-27 E. I. Du Pont De Nemours And Company MUTANT ACYL-CoA:LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASES
GB201217524D0 (en) 2012-10-01 2012-11-14 Rothamsted Res Ltd Recombinant organisms
EA037817B1 (ru) 2013-12-18 2021-05-25 Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн Экстрагированный растительный липид, содержащий длинноцепочечные полиненасыщенные жирные кислоты
CA2953008C (en) 2014-06-27 2024-03-19 Nuseed Pty Ltd Lipid comprising docosapentaenoic acid
CN108410916A (zh) * 2018-05-30 2018-08-17 湖北福星生物科技有限公司 花生四烯酸油脂的生产方法
CN111317068A (zh) * 2020-01-15 2020-06-23 广州市优百特饲料科技有限公司 饲用opo母乳结构脂及其制备方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614393A (en) * 1991-10-10 1997-03-25 Rhone-Poulenc Agrochimie Production of γ-linolenic acid by a Δ6-desaturase
PH31293A (en) * 1991-10-10 1998-07-06 Rhone Poulenc Agrochimie Production of y-linolenic acid by a delta6-desaturage.
AU673994B2 (en) * 1992-03-13 1996-12-05 Agrigenetics, Inc. Modification of vegetable oil with desaturase
WO1994011516A1 (en) * 1992-11-17 1994-05-26 E.I. Du Pont De Nemours And Company Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants
US7205457B1 (en) * 1993-02-05 2007-04-17 Monsanto Technology Llc Altered linolenic and linoleic acid content in plants
US6310194B1 (en) * 1994-09-26 2001-10-30 Carnegie Institution Of Washington Plant fatty acid hydroxylases

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100339481C (zh) * 2005-03-17 2007-09-26 东北师范大学 应用基因沉默技术提高大豆和花生的种子油酸含量的方法
US7893321B2 (en) 2005-05-23 2011-02-22 Arcadia Biosciences, Inc. Safflower with elevated gamma-linolenic acid
US8192964B2 (en) 2005-05-23 2012-06-05 Arcadia Biosciences, Inc. Safflower with elevated gamma-linolenic acid
CN101321872B (zh) * 2005-05-23 2012-09-05 阿凯迪亚生物科学公司 高γ-亚麻酸红花
CN1302110C (zh) * 2005-06-23 2007-02-28 复旦大学 水稻Osfad8编码序列及其应用
CN113957105A (zh) * 2008-11-18 2022-01-21 联邦科学技术研究组织 产生ω-3脂肪酸的酶和方法
CN104839353A (zh) * 2015-04-30 2015-08-19 安庆市顺民粮油贸易有限公司 一种幼儿保健食用油及其制作方法
CN105400838A (zh) * 2015-12-30 2016-03-16 厦门金达威集团股份有限公司 一种生物酶催化制备磷脂型dha的方法

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