CN1228079A - 制备5－[乙酰基(2,3－二羟基丙基)氨基－n,n'－双(2,3－二羟基丙基)－2,4,6－三碘－1,3－苯二甲酰胺的方法 - Google Patents

制备5－[乙酰基(2,3－二羟基丙基)氨基－n,n'－双(2,3－二羟基丙基)－2,4,6－三碘－1,3－苯二甲酰胺的方法 Download PDF

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Publication number
CN1228079A
CN1228079A CN98800714A CN98800714A CN1228079A CN 1228079 A CN1228079 A CN 1228079A CN 98800714 A CN98800714 A CN 98800714A CN 98800714 A CN98800714 A CN 98800714A CN 1228079 A CN1228079 A CN 1228079A
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China
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compound
amino
reaction
iii
formula
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CN98800714A
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English (en)
Chinese (zh)
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N·迪桑提斯
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Bracco SpA
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Bracco SpA
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Publication of CN1228079A publication Critical patent/CN1228079A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
CN98800714A 1997-05-30 1998-05-19 制备5－[乙酰基(2,3－二羟基丙基)氨基－n,n'－双(2,3－二羟基丙基)－2,4,6－三碘－1,3－苯二甲酰胺的方法 Pending CN1228079A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI001268A IT1292037B1 (it) 1997-05-30 1997-05-30 Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen-
ITMI97A001268 1997-05-30

Publications (1)

Publication Number Publication Date
CN1228079A true CN1228079A (zh) 1999-09-08

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ID=11377250

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98800714A Pending CN1228079A (zh) 1997-05-30 1998-05-19 制备5－[乙酰基(2,3－二羟基丙基)氨基－n,n'－双(2,3－二羟基丙基)－2,4,6－三碘－1,3－苯二甲酰胺的方法

Country Status (18)

Country Link
US (1) US5965772A (enExample)
EP (1) EP0915835B1 (enExample)
JP (1) JP3437584B2 (enExample)
KR (1) KR20000029649A (enExample)
CN (1) CN1228079A (enExample)
AT (1) ATE198191T1 (enExample)
AU (1) AU729759B2 (enExample)
CA (1) CA2261656A1 (enExample)
CZ (1) CZ25399A3 (enExample)
DE (1) DE69800434T2 (enExample)
DK (1) DK0915835T3 (enExample)
ES (1) ES2152747T3 (enExample)
GR (1) GR3035123T3 (enExample)
IT (1) IT1292037B1 (enExample)
NO (1) NO323475B1 (enExample)
PL (1) PL331208A1 (enExample)
PT (1) PT915835E (enExample)
WO (1) WO1998054124A1 (enExample)

Cited By (6)

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CN100344606C (zh) * 2005-12-28 2007-10-24 江苏省原子医学研究所 一种碘昔兰的制备方法
CN102216259A (zh) * 2008-11-18 2011-10-12 伯拉考成像股份公司 制备碘化的造影剂的方法
CN103228620A (zh) * 2010-07-15 2013-07-31 伯拉考成像股份公司 造影剂的制备方法
CN106316878A (zh) * 2015-06-15 2017-01-11 重庆常捷医药有限公司 一种碘美普尔杂质的制备方法
CN113166040A (zh) * 2018-09-17 2021-07-23 Uk化学药剂有限公司 制备造影剂碘美普尔的方法
CN113387833A (zh) * 2021-05-25 2021-09-14 成都丽璟科技有限公司 一种低渗透性泛影酸衍生物造影剂及其制备方法

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SE520688C2 (sv) * 2000-04-11 2003-08-12 Bone Support Ab Ett injicerbart ersättningsmaterial för benmineral
SE517168C2 (sv) * 2000-07-17 2002-04-23 Bone Support Ab En komposition för ett injicerbart ersättningsmaterial för benmineral
SE522098C2 (sv) 2001-12-20 2004-01-13 Bone Support Ab Ett nytt benmineralsubstitut
SE0300620D0 (sv) 2003-03-05 2003-03-05 Bone Support Ab A new bone substitute composition
WO2004087637A1 (en) * 2003-03-31 2004-10-14 Takasago International Corporation Production of n-alkylamide compounds
SE0302983D0 (sv) * 2003-11-11 2003-11-11 Bone Support Ab Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed
SE527528C2 (sv) 2004-06-22 2006-04-04 Bone Support Ab Anordning för framställning av härdbar massa samt användning av anordningen
PT103391B (pt) * 2005-11-24 2008-10-30 Hovione Farmaciencia S A Processo para fabrico de lohexol
CA2684067A1 (en) 2007-04-25 2008-11-06 F. Hoffmann-La Roche Ag Novel process for the preparation of acid chlorides
ES2460900T3 (es) 2008-04-04 2014-05-14 F. Hoffmann-La Roche Ag Nuevo procedimiento para la preparación de derivados de ácido ciclohexanocarboxílico mediante el correspondiente derivado ciclohexanocarboxamida
JP5564487B2 (ja) 2008-04-04 2014-07-30 エフ．ホフマン−ラ ロシュ アーゲー シクロヘキサンカルボン酸誘導体の新規な製造方法
KR101098553B1 (ko) * 2008-04-30 2011-12-26 주식회사 엘지생명과학 이오프로마이드의 신규한 제조방법
WO2009153181A1 (en) 2008-06-17 2009-12-23 F. Hoffmann-La Roche Ag 1-(2-ethyl-butyl) -cyclohexanecarboxylic acid ester as an intermediate in the preparation of pharmaceutically active amides
WO2011063551A1 (en) 2009-11-26 2011-06-03 Hovione China Holding Limited Preparation and purification of iodixanol
US9180137B2 (en) 2010-02-09 2015-11-10 Bone Support Ab Preparation of bone cement compositions
TR201807495T4 (tr) 2013-02-20 2018-06-21 Bone Support Ab Sertleştirilebilir kemik ikamesine yönelik geliştirilmiş katılaştırma.
KR101520187B1 (ko) * 2013-10-25 2015-05-13 주식회사 대웅제약 이오프로마이드의 중간체의 제조방법
CN110023279B (zh) 2016-12-05 2022-03-11 伯拉考成像股份公司 放射照相剂中间体的机械化学合成
CN114478298B (zh) * 2020-11-12 2024-09-27 成都西岭源药业有限公司 一种造影剂碘佛醇的纯化方法
CN115872894B (zh) * 2022-11-15 2024-12-24 上海慧聚药业有限公司 非离子型造影剂的合成
CN116332787B (zh) * 2023-03-03 2023-10-27 安庆朗坤药业有限公司 一种造影剂中间体乙酰碘化物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (enExample) * 1974-12-13 1978-12-29 Savac Ag
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DK0773924T3 (da) * 1995-05-23 1999-09-20 Fructamine Spa Fremgangsmåde til fremstilling af et dicarboxylsyredichlorid

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100344606C (zh) * 2005-12-28 2007-10-24 江苏省原子医学研究所 一种碘昔兰的制备方法
CN102216259A (zh) * 2008-11-18 2011-10-12 伯拉考成像股份公司 制备碘化的造影剂的方法
CN102216259B (zh) * 2008-11-18 2016-01-20 伯拉考成像股份公司 制备碘化的造影剂的方法
CN103228620A (zh) * 2010-07-15 2013-07-31 伯拉考成像股份公司 造影剂的制备方法
CN103228620B (zh) * 2010-07-15 2014-11-26 伯拉考成像股份公司 造影剂的制备方法
CN106316878A (zh) * 2015-06-15 2017-01-11 重庆常捷医药有限公司 一种碘美普尔杂质的制备方法
CN106316878B (zh) * 2015-06-15 2018-01-19 重庆常捷医药有限公司 一种碘美普尔杂质的制备方法
CN113166040A (zh) * 2018-09-17 2021-07-23 Uk化学药剂有限公司 制备造影剂碘美普尔的方法
CN113166040B (zh) * 2018-09-17 2023-10-24 Uk化学药剂有限公司 制备造影剂碘美普尔的方法
CN113387833A (zh) * 2021-05-25 2021-09-14 成都丽璟科技有限公司 一种低渗透性泛影酸衍生物造影剂及其制备方法

Also Published As

Publication number Publication date
JP3437584B2 (ja) 2003-08-18
DE69800434T2 (de) 2001-04-19
IT1292037B1 (it) 1999-01-25
DK0915835T3 (da) 2001-02-05
ES2152747T3 (es) 2001-02-01
PT915835E (pt) 2001-03-30
WO1998054124A1 (en) 1998-12-03
JP2000505820A (ja) 2000-05-16
EP0915835B1 (en) 2000-12-20
ATE198191T1 (de) 2001-01-15
AU729759B2 (en) 2001-02-08
ITMI971268A0 (enExample) 1997-05-30
PL331208A1 (en) 1999-07-05
CZ25399A3 (cs) 1999-07-14
US5965772A (en) 1999-10-12
DE69800434D1 (de) 2001-01-25
NO990334D0 (no) 1999-01-25
AU8018598A (en) 1998-12-30
ITMI971268A1 (it) 1998-11-30
NO323475B1 (no) 2007-05-21
CA2261656A1 (en) 1998-12-03
EP0915835A1 (en) 1999-05-19
KR20000029649A (ko) 2000-05-25
GR3035123T3 (en) 2001-03-30
NO990334L (no) 1999-03-26

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