CN1200734C - 用表皮生长因子拮抗物治疗顽固性的人肿瘤 - Google Patents

用表皮生长因子拮抗物治疗顽固性的人肿瘤 Download PDF

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Publication number
CN1200734C
CN1200734C CNB008103216A CN00810321A CN1200734C CN 1200734 C CN1200734 C CN 1200734C CN B008103216 A CNB008103216 A CN B008103216A CN 00810321 A CN00810321 A CN 00810321A CN 1200734 C CN1200734 C CN 1200734C
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CN
China
Prior art keywords
egfr
antibody
antagonist
refractory
tumor
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Expired - Fee Related
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CNB008103216A
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English (en)
Chinese (zh)
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CN1361700A (zh
Inventor
H·W·瓦克萨尔
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ImClone LLC
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ImClone Systems Inc
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Publication of CN1361700A publication Critical patent/CN1361700A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CNB008103216A 1999-05-14 2000-05-01 用表皮生长因子拮抗物治疗顽固性的人肿瘤 Expired - Fee Related CN1200734C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31228499A 1999-05-14 1999-05-14
US09/312,284 1999-05-14
US37402899A 1999-08-13 1999-08-13
US09/374,028 1999-08-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN 200510055865 Division CN1720994A (zh) 1999-05-14 2000-05-01 用表皮生长因子受体拮抗物治疗顽固性的人肿瘤

Publications (2)

Publication Number Publication Date
CN1361700A CN1361700A (zh) 2002-07-31
CN1200734C true CN1200734C (zh) 2005-05-11

Family

ID=26978320

Family Applications (1)

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CNB008103216A Expired - Fee Related CN1200734C (zh) 1999-05-14 2000-05-01 用表皮生长因子拮抗物治疗顽固性的人肿瘤

Country Status (20)

Country Link
US (3) US20020012663A1 (enExample)
EP (2) EP2042194A3 (enExample)
JP (2) JP2003520195A (enExample)
KR (1) KR20020000223A (enExample)
CN (1) CN1200734C (enExample)
AU (1) AU782994C (enExample)
BG (1) BG106110A (enExample)
BR (1) BR0010524A (enExample)
CA (1) CA2373815A1 (enExample)
CZ (1) CZ20014083A3 (enExample)
EE (1) EE200100603A (enExample)
HK (1) HK1047236A1 (enExample)
HU (1) HUP0201480A3 (enExample)
IL (1) IL146480A0 (enExample)
MX (1) MXPA01011632A (enExample)
NO (1) NO20015546L (enExample)
PL (1) PL365999A1 (enExample)
RU (1) RU2294761C2 (enExample)
SK (1) SK16522001A3 (enExample)
WO (1) WO2000069459A1 (enExample)

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Conclusion of examination: In the May 11, 2005 notice of authorization in claim 2, 9, 25-29, 4-8 in a direct or indirect reference to claim 2 of the technical scheme of claim and claim 10-24 in a direct or indirect reference to claim 2 or 9 based on the maintenance of No. 810321.6 invention patents; declare the patent authorization proclamation in the text claim 1, 3, 30, 31, and other technology solutions, 4-8 claims 10-24 is invalid.

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