CN1185223C - 新颖化合物,其合成方法及治疗用途 - Google Patents

新颖化合物,其合成方法及治疗用途 Download PDF

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Publication number
CN1185223C
CN1185223C CNB961901330A CN96190133A CN1185223C CN 1185223 C CN1185223 C CN 1185223C CN B961901330 A CNB961901330 A CN B961901330A CN 96190133 A CN96190133 A CN 96190133A CN 1185223 C CN1185223 C CN 1185223C
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acid
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CNB961901330A
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Chinese (zh)
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CN1147813A (zh
Inventor
诺伯特·毕乔夫伯格
金正恩
威勒德·雷
刘洪涛
马修·威廉斯
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Gilead Sciences Inc
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Gilead Sciences Inc
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Priority claimed from US08/476,946 external-priority patent/US5866601A/en
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Priority to CN201310726136.6A priority Critical patent/CN103772231B/zh
Publication of CN1147813A publication Critical patent/CN1147813A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
CNB961901330A 1995-02-27 1996-02-26 新颖化合物,其合成方法及治疗用途 Expired - Lifetime CN1185223C (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310726136.6A CN103772231B (zh) 1995-02-27 1996-02-26 新颖化合物，其合成方法及治疗用途

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US39524595A 1995-02-27 1995-02-27
US08/395,245 1995-02-27
US08/476,946 1995-06-06
US08/476,946 US5866601A (en) 1995-02-27 1995-06-06 Carbocyclic compounds
US58056795A 1995-12-29 1995-12-29
US08/580,567 1995-12-29

Related Child Applications (5)

Application Number Title Priority Date Filing Date
CN201310726136.6A Division CN103772231B (zh) 1995-02-27 1996-02-26 新颖化合物，其合成方法及治疗用途
CNB011247142A Division CN100409844C (zh) 1995-02-27 1996-02-26 神经氨酸苷酶抑制剂
CN2007101383557A Division CN101172957B (zh) 1995-02-27 1996-02-26 新颖化合物,其合成方法及治疗用途
CNA2007101383542A Division CN101143859A (zh) 1995-02-27 1996-02-26 新颖化合物,其合成方法及治疗用途
CN2012103595715A Division CN102952033A (zh) 1995-02-27 1996-02-26 新颖化合物,其合成方法及治疗用途

Publications (2)

Publication Number Publication Date
CN1147813A CN1147813A (zh) 1997-04-16
CN1185223C true CN1185223C (zh) 2005-01-19

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CNB961901330A Expired - Lifetime CN1185223C (zh) 1995-02-27 1996-02-26 新颖化合物,其合成方法及治疗用途
CNB011247142A Expired - Lifetime CN100409844C (zh) 1995-02-27 1996-02-26 神经氨酸苷酶抑制剂

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EP (1) EP0759917B1 (enExample)
JP (3) JP3300365B2 (enExample)
KR (1) KR100447096B1 (enExample)
CN (2) CN1185223C (enExample)
AT (2) ATE191711T1 (enExample)
AU (1) AU720933B2 (enExample)
BR (2) BR9607098A (enExample)
CZ (1) CZ297945B6 (enExample)
DE (4) DE69607704T2 (enExample)
DK (1) DK0759917T3 (enExample)
ES (2) ES2249863T3 (enExample)
GR (1) GR3033914T3 (enExample)
HU (1) HU228450B1 (enExample)
LU (1) LU90991I2 (enExample)
MX (1) MX9706496A (enExample)
NL (1) NL300105I2 (enExample)
NO (1) NO318455B1 (enExample)
NZ (1) NZ306625A (enExample)
PL (1) PL194173B1 (enExample)
PT (1) PT759917E (enExample)
RU (1) RU2181357C2 (enExample)
SG (1) SG45864A1 (enExample)
SI (1) SI9620042A (enExample)
UA (1) UA56128C2 (enExample)
WO (1) WO1996026933A1 (enExample)

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PT759917E (pt) 2000-10-31
HK1026893A1 (en) 2000-12-29
JP3300365B2 (ja) 2002-07-08
ES2249863T3 (es) 2006-04-01
CN1347693A (zh) 2002-05-08
SI9620042A (sl) 1998-12-31
NO318455B1 (no) 2005-03-21
US5952375A (en) 1999-09-14
EP0759917A1 (en) 1997-03-05
JP4234917B2 (ja) 2009-03-04
PL194173B1 (pl) 2007-05-31
HUP9800026A2 (hu) 1999-09-28
BR9607098B8 (pt) 2014-11-18
CZ297945B6 (cs) 2007-05-02
NL300105I2 (nl) 2003-02-03
DE69607704D1 (de) 2000-05-18
HUP9800026A3 (en) 2002-04-29
DE759917T1 (de) 1998-10-22
US20050176758A1 (en) 2005-08-11
RU2181357C2 (ru) 2002-04-20
HU228450B1 (en) 2013-03-28
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SG45864A1 (en) 1999-04-27
KR100447096B1 (ko) 2005-10-11
DE69635231T2 (de) 2006-07-13
WO1996026933A1 (en) 1996-09-06
AU720933B2 (en) 2000-06-15
US6225341B1 (en) 2001-05-01
ATE191711T1 (de) 2000-04-15
NO973908L (no) 1997-10-27
CN1147813A (zh) 1997-04-16
ATE305453T1 (de) 2005-10-15
UA56128C2 (uk) 2003-05-15
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KR19980703600A (ko) 1998-12-05
JP2002161074A (ja) 2002-06-04
BR9607098A (pt) 1997-11-04
DE10299052I1 (de) 2003-05-22
LU90991I2 (fr) 2003-02-11
NO973908D0 (no) 1997-08-26
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AU5357196A (en) 1996-09-18
PL322000A1 (en) 1998-01-05
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