ES2118674T1 - Nuevos inhibidores selectivos de neuraminidasas virales o bacterianas. - Google Patents
Nuevos inhibidores selectivos de neuraminidasas virales o bacterianas.Info
- Publication number
- ES2118674T1 ES2118674T1 ES96912404T ES96912404T ES2118674T1 ES 2118674 T1 ES2118674 T1 ES 2118674T1 ES 96912404 T ES96912404 T ES 96912404T ES 96912404 T ES96912404 T ES 96912404T ES 2118674 T1 ES2118674 T1 ES 2118674T1
- Authority
- ES
- Spain
- Prior art keywords
- group
- viral
- selective inhibitors
- new selective
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940124639 Selective inhibitor Drugs 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 AMINO Chemical class 0.000 abstract 2
- 102000005348 Neuraminidase Human genes 0.000 abstract 2
- 108010006232 Neuraminidase Proteins 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 238000010998 test method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Epoxy Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyesters Or Polycarbonates (AREA)
- Pyrane Compounds (AREA)
Abstract
SE DESCRIBEN NUEVOS COMPUESTOS. LOS COMPUESTOS GENERALMENTE COMPRENDEN UN GRUPO ACIDO, UN GRUPO BASICO, UN GRUPO AMINO O NACILO SUSTITUIDO Y UN GRUPO CON UNA FRACCION ALCANO OPCIONALMENTE HIDROXILADO. TAMBIEN SE DESCRIBEN COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN LOS INHIBIDORES OBJETO DE LA INVENCION. SE DESCRIBEN TAMBIEN METODOS DE INHIBICION DE NEURAMINIDASA EN MUESTRAS EN LAS QUE SE SOSPECHA LA PRESENCIA DE LA MISMA. SE DESCRIBEN TAMBIEN MATERIALES ANTIGENICOS, POLIMEROS, ANTICUERPOS, CONJUGADOS DE LOS COMPUESTOS DE LA INVENCION CON TRAZADORES, Y METODOS DE ENSAYO PARA DETECTAR LA ACTIVIDAD DE NEURAMINIDASA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39524595A | 1995-02-27 | 1995-02-27 | |
US08/476,946 US5866601A (en) | 1995-02-27 | 1995-06-06 | Carbocyclic compounds |
US58056795A | 1995-12-29 | 1995-12-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2118674T1 true ES2118674T1 (es) | 1998-10-01 |
ES2118674T3 ES2118674T3 (es) | 2000-08-16 |
Family
ID=27410155
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99117934T Expired - Lifetime ES2249863T3 (es) | 1995-02-27 | 1996-02-26 | Inhibidores selectivos de neuraminidasa viral o bacteriana. |
ES96912404T Expired - Lifetime ES2118674T3 (es) | 1995-02-27 | 1996-02-26 | Nuevos inhibidores selectivos de neuraminidasas virales o bactericidas. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99117934T Expired - Lifetime ES2249863T3 (es) | 1995-02-27 | 1996-02-26 | Inhibidores selectivos de neuraminidasa viral o bacteriana. |
Country Status (27)
Country | Link |
---|---|
US (3) | US5952375A (es) |
EP (1) | EP0759917B1 (es) |
JP (3) | JP3300365B2 (es) |
KR (1) | KR100447096B1 (es) |
CN (2) | CN1185223C (es) |
AT (2) | ATE305453T1 (es) |
AU (1) | AU720933B2 (es) |
BR (2) | BR9607098A (es) |
CZ (1) | CZ297945B6 (es) |
DE (4) | DE69607704T2 (es) |
DK (1) | DK0759917T3 (es) |
ES (2) | ES2249863T3 (es) |
GR (1) | GR3033914T3 (es) |
HK (1) | HK1026893A1 (es) |
HU (1) | HU228450B1 (es) |
LU (1) | LU90991I2 (es) |
MX (1) | MX9706496A (es) |
NL (1) | NL300105I2 (es) |
NO (1) | NO318455B1 (es) |
NZ (1) | NZ306625A (es) |
PL (1) | PL194173B1 (es) |
PT (1) | PT759917E (es) |
RU (1) | RU2181357C2 (es) |
SG (1) | SG45864A1 (es) |
SI (1) | SI9620042A (es) |
UA (1) | UA56128C2 (es) |
WO (1) | WO1996026933A1 (es) |
Families Citing this family (85)
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HU228450B1 (en) * | 1995-02-27 | 2013-03-28 | Gilead Sciences Inc | Novel selective inhibitors of viral or bacterial neuraminidases |
US5714509A (en) * | 1995-05-03 | 1998-02-03 | The University Of Alabama | Inhibitors of bacterial sialidase and methods of making and using the same |
US5763483A (en) * | 1995-12-29 | 1998-06-09 | Gilead Sciences, Inc. | Carbocyclic compounds |
US6093816A (en) | 1996-06-27 | 2000-07-25 | Isis Pharmaceuticals, Inc. | Cationic lipids |
MXPA99001697A (es) * | 1996-08-23 | 2004-04-05 | Gilead Sciences Inc | Preparacion de derivados de carboxilato de ciclohexeno. |
US6518438B2 (en) | 1996-08-23 | 2003-02-11 | Gilead Sciences, Inc. | Preparation of cyclohexene carboxylate derivatives |
US5859284A (en) | 1996-08-23 | 1999-01-12 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
US5994377A (en) | 1996-10-21 | 1999-11-30 | Gilead Sciences, Inc. | Piperidine compounds |
KR20000052702A (ko) * | 1996-10-21 | 2000-08-25 | 헨슬레이 맥스 디. | 피페리딘 화합물 |
JP3691075B2 (ja) * | 1996-11-14 | 2005-08-31 | バイオタ、サイアンティフィック、マネージメント、プロプライエタリ、リミテッド | 新規化合物およびその使用方法 |
AU8673598A (en) * | 1997-08-01 | 1999-02-22 | University Of Florida | Neuraminidase inhibitors |
US5886213A (en) * | 1997-08-22 | 1999-03-23 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
WO1999014185A1 (en) * | 1997-09-17 | 1999-03-25 | Gilead Sciences, Inc. | Compounds containing six-membered rings, processes for their preparation, and their use as medicaments |
US20040053999A1 (en) * | 1997-09-17 | 2004-03-18 | Bischofberger Norbert W. | Novel compounds and methods for synthesis and therapy |
TW480247B (en) * | 1997-12-12 | 2002-03-21 | Gilead Sciences Inc | Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same |
SK8712000A3 (en) * | 1997-12-17 | 2000-11-07 | Biocryst Pharm Inc | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
US6455571B1 (en) | 1998-04-23 | 2002-09-24 | Abbott Laboratories | Inhibitors of neuraminidases |
US6518305B1 (en) | 1998-04-23 | 2003-02-11 | Abbott Laboratories | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases |
AU3554599A (en) * | 1998-04-23 | 1999-11-08 | Abbott Laboratories | Pyrrolidines as inhibitors of neuraminidases |
EP0957078B1 (en) * | 1998-05-13 | 2001-11-28 | F. Hoffmann-La Roche Ag | Process for the preparation of shikimic acid and its derivatives |
AU1476900A (en) * | 1998-11-13 | 2000-06-05 | Gilead Sciences, Inc. | 1,4,5,6-tetrahydro-pyridazine derivatives, their preparation and their use as neuraminidase inhibitors |
AUPP913999A0 (en) * | 1999-03-12 | 1999-04-01 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
DK1059283T3 (da) * | 1999-06-11 | 2003-09-15 | Hoffmann La Roche | Fremgangsmåde til fremstilling af neuraminidase-inhibitor ro-64-0796 |
DE19930177B4 (de) | 1999-06-30 | 2007-02-08 | Nikolai Vladimirovich Bovin | Intermolekular assoziierende Verbindungen und deren Verwendung |
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US6593314B1 (en) * | 1999-10-19 | 2003-07-15 | Abbott Laboratories | Neuraminidase inhibitors |
US6627396B1 (en) * | 1999-10-28 | 2003-09-30 | The Regents Of The University Of California | Influenza sensor |
JP2001131144A (ja) * | 1999-11-02 | 2001-05-15 | Sagami Chem Res Center | 7−アザビシクロ[4.1.0]ヘプト−3−エン−3−カルボン酸エステル類の製造方法 |
US6462226B1 (en) | 1999-12-03 | 2002-10-08 | Hoffmann-La Roche Inc. | Process for the preparation of 4,5-diamino shikimic acid derivatives |
WO2001047906A1 (fr) * | 1999-12-27 | 2001-07-05 | Sagami Chemical Research Center | Methode de production d'esters d'acides 5-oxy-7-oxabicyclo-[4.1.0]hept-3-ene-3-carboxyliques |
US8642051B2 (en) * | 2000-03-21 | 2014-02-04 | Suzanne Jaffe Stillman | Method of hydration; infusion packet system(s), support member(s), delivery system(s), and method(s); with business model(s) and Method(s) |
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