BR0010525A - cido 1-ciclo-hexeno-1-carboxìlico e 1-ciclo-hexeno-1carboxilatos como inibidores de neuraminidase - Google Patents
cido 1-ciclo-hexeno-1-carboxìlico e 1-ciclo-hexeno-1carboxilatos como inibidores de neuraminidaseInfo
- Publication number
- BR0010525A BR0010525A BR0010525-2A BR0010525A BR0010525A BR 0010525 A BR0010525 A BR 0010525A BR 0010525 A BR0010525 A BR 0010525A BR 0010525 A BR0010525 A BR 0010525A
- Authority
- BR
- Brazil
- Prior art keywords
- cyclohexene
- neuraminidase
- carboxylic acid
- compounds
- neuraminidase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"áCIDO 1-CICLO-HEXENO-1-CARBOXìLICO E 1-CICLO-HEXENO-1-CARBOXILATOS COMO INIBIDORES DE NEURAMINIDASE". A presente invenção fornece compostos das fórmulas Ia e Ib ou um seu sal, pró-medicamento, ou éster de uso farmacêutico, úteis para inibir enzimas neuraminidase de microorganismos causadores de doenças, especialmente neuraminidase de influenza, formulações farmacêuticas que contêm os mesmas, processos e intermediários para preparar esses compostos, bem como métodos para usar os ditos compostos, inclusive para prevenir e tratar doenças causadas por microorganismos que têm a dita enzima neuraminidase.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42107799A | 1999-10-19 | 1999-10-19 | |
US42809399A | 1999-10-27 | 1999-10-27 | |
PCT/US2000/026119 WO2001028981A1 (en) | 1999-10-19 | 2000-09-22 | 1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1-carboxylates as neuraminidase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0010525A true BR0010525A (pt) | 2002-11-26 |
Family
ID=27025098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0010525-2A BR0010525A (pt) | 1999-10-19 | 2000-09-22 | cido 1-ciclo-hexeno-1-carboxìlico e 1-ciclo-hexeno-1carboxilatos como inibidores de neuraminidase |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU7608100A (pt) |
BR (1) | BR0010525A (pt) |
WO (1) | WO2001028981A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6403824B2 (en) * | 2000-02-22 | 2002-06-11 | Hoffmann-La Roche Inc. | Process for the preparation for 4,5-diamino shikimic acid derivatives |
AU2002333601A1 (en) | 2001-09-14 | 2003-04-01 | Asm America, Inc. | Metal nitride deposition by ald using gettering reactant |
US7122684B2 (en) | 2003-03-13 | 2006-10-17 | Roche Colorado Corporation | Process for preparing 1,2-diamino compounds |
US20120010254A1 (en) * | 2008-12-30 | 2012-01-12 | Simon Fraser University | Compounds and methods for treatment of influenza |
CN111470999A (zh) * | 2020-05-18 | 2020-07-31 | 中山万汉制药有限公司 | N-环己烯基-脂肪酰胺类化合物及其制备方法、组合物与用途 |
CN116354869A (zh) * | 2023-02-13 | 2023-06-30 | 北京恒创星远医药科技有限公司 | 一种环己烯类抗病毒化合物的合成工艺 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI9620042A (sl) * | 1995-02-27 | 1998-12-31 | Gilead Sciences, Inc. | Novi selektivni inhibitorji virusnih ali bakterijskih neuraminidaz |
US5763483A (en) * | 1995-12-29 | 1998-06-09 | Gilead Sciences, Inc. | Carbocyclic compounds |
WO1999014185A1 (en) * | 1997-09-17 | 1999-03-25 | Gilead Sciences, Inc. | Compounds containing six-membered rings, processes for their preparation, and their use as medicaments |
TW480247B (en) * | 1997-12-12 | 2002-03-21 | Gilead Sciences Inc | Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same |
-
2000
- 2000-09-22 AU AU76081/00A patent/AU7608100A/en not_active Abandoned
- 2000-09-22 BR BR0010525-2A patent/BR0010525A/pt not_active Application Discontinuation
- 2000-09-22 WO PCT/US2000/026119 patent/WO2001028981A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
AU7608100A (en) | 2001-04-30 |
WO2001028981A1 (en) | 2001-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |