IL143639A0 - Method for determining the activity of a substance using a functional test in vitro - Google Patents

Method for determining the activity of a substance using a functional test in vitro

Info

Publication number
IL143639A0
IL143639A0 IL14363999A IL14363999A IL143639A0 IL 143639 A0 IL143639 A0 IL 143639A0 IL 14363999 A IL14363999 A IL 14363999A IL 14363999 A IL14363999 A IL 14363999A IL 143639 A0 IL143639 A0 IL 143639A0
Authority
IL
Israel
Prior art keywords
vitro
substance
activity
determining
functional test
Prior art date
Application number
IL14363999A
Original Assignee
Proteus Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteus Sa filed Critical Proteus Sa
Publication of IL143639A0 publication Critical patent/IL143639A0/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

Determining the activity of a substance (A) in a functional test (FT) comprising detecting and/or measuring the variation of a known function that corresponds to at least 1 protein (B) in vitro, in presence and absence of (A), or detecting and/or measuring (A), in presence and in absence of (B), is new. Independent claims are also included for the following: (a) a kit for performing the FT; (b) a support for performing the FT comprising a series of locations, each of which allows the detection and/or measurement of a variation of function; and (c) a process for developing new FTs.
IL14363999A 1998-12-08 1999-12-08 Method for determining the activity of a substance using a functional test in vitro IL143639A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9815488A FR2786788B1 (en) 1998-12-08 1998-12-08 METHOD FOR SCREENING SUBSTANCES CAPABLE OF ALTERING THE ACTIVITY OF ONE OR MORE TARGET PROTEINS OR OF A TARGET SET OF PROTEINS EXPRESSED IN VITRO
PCT/FR1999/003062 WO2000034514A1 (en) 1998-12-08 1999-12-08 METHOD FOR DETERMINING THE ACTIVITY OF A SUBSTANCE USING A FUNCTIONAL TEST $i(IN VITRO)

Publications (1)

Publication Number Publication Date
IL143639A0 true IL143639A0 (en) 2002-04-21

Family

ID=9533725

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14363999A IL143639A0 (en) 1998-12-08 1999-12-08 Method for determining the activity of a substance using a functional test in vitro
IL143639A IL143639A (en) 1998-12-08 2001-06-07 Method for determining the activity of a substance using a functional test in vitro

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL143639A IL143639A (en) 1998-12-08 2001-06-07 Method for determining the activity of a substance using a functional test in vitro

Country Status (9)

Country Link
EP (2) EP1137802B1 (en)
JP (1) JP2002531851A (en)
AT (1) ATE317454T1 (en)
AU (1) AU779179B2 (en)
CA (1) CA2354572A1 (en)
DE (1) DE69929817T2 (en)
FR (1) FR2786788B1 (en)
IL (2) IL143639A0 (en)
WO (1) WO2000034514A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1160332A1 (en) * 2000-05-30 2001-12-05 Amsterdam Support Diagnostics B.V. Methods for detecting enzymatic activity or detecting resistance to enzyme inhibitors
WO2002008766A1 (en) * 2000-07-26 2002-01-31 Japan Science And Technology Corporation Probe for analyzing protein-protein interaction and method of analyzing protein-protein interactions with the use of the same
DE10158904A1 (en) * 2001-11-30 2003-06-12 Roche Diagnostics Gmbh Process for the preparation of linear DNA fragments for the in vitro expression of proteins

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4557862A (en) * 1983-10-28 1985-12-10 University Patents, Inc. Rhodamine derivatives as fluorogenic substrates for proteinases
WO1992007949A1 (en) * 1990-11-05 1992-05-14 The United States Of America, As Represented By The Secretary Of The Army Method for the in vitro production of protein from a dna sequence without cloning
US5235039A (en) * 1991-06-10 1993-08-10 Eli Lilly And Company Substrates for hiv protease
JPH07184648A (en) * 1992-02-07 1995-07-25 Kunitada Shimotoono Hcv proteinase active substance, its production and method for assaying the same proteinase and inhibitor for the same poteinase
AU4843893A (en) * 1992-09-02 1994-03-29 Scripps Research Institute, The Coupled isothermal polynucleotide amplification and translation system
US5436131A (en) * 1993-04-02 1995-07-25 Merck & Co., Inc. Color screening assay for identifying inhibitor resistant HIV protease mutants
CA2159899A1 (en) * 1993-04-08 1994-10-27 Wieslaw Kudlicki Cell free system for protein synthesis and use of chaperone proteins therein
GB9320562D0 (en) * 1993-10-06 1993-11-24 Zeneca Ltd Novel assay and applications
US5763198A (en) * 1994-07-22 1998-06-09 Sugen, Inc. Screening assays for compounds
US6063562A (en) * 1994-09-16 2000-05-16 Sepracor, Inc. In vitro method for predicting the evolutionary response of HIV protease to a drug targeted thereagainst
DE19710159A1 (en) * 1997-03-12 1998-10-01 Hoechst Ag In vitro transcription process for the screening of natural products and other chemical substances

Also Published As

Publication number Publication date
FR2786788B1 (en) 2002-04-19
DE69929817D1 (en) 2006-04-20
CA2354572A1 (en) 2000-06-15
JP2002531851A (en) 2002-09-24
ATE317454T1 (en) 2006-02-15
AU1510000A (en) 2000-06-26
EP1666612A3 (en) 2006-06-21
AU779179B2 (en) 2005-01-13
EP1137802A1 (en) 2001-10-04
EP1666612A2 (en) 2006-06-07
WO2000034514A1 (en) 2000-06-15
IL143639A (en) 2007-08-19
FR2786788A1 (en) 2000-06-09
DE69929817T2 (en) 2006-12-28
EP1137802B1 (en) 2006-02-08

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