CN1184480A - 碳代青霉烯酯 - Google Patents

碳代青霉烯酯 Download PDF

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Publication number
CN1184480A
CN1184480A CN96194015A CN96194015A CN1184480A CN 1184480 A CN1184480 A CN 1184480A CN 96194015 A CN96194015 A CN 96194015A CN 96194015 A CN96194015 A CN 96194015A CN 1184480 A CN1184480 A CN 1184480A
Authority
CN
China
Prior art keywords
alkyl
group
compound
formula
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96194015A
Other languages
English (en)
Chinese (zh)
Inventor
乔治·伯顿
斯蒂芬·C·M·费尔
艾尔弗雷德·J·艾格林顿
斯蒂芬·F·莫斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SMIHKLINE BEECHAM PLC
SmithKline Beecham Ltd
Original Assignee
SMIHKLINE BEECHAM PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9508960.3A external-priority patent/GB9508960D0/en
Priority claimed from GBGB9508959.5A external-priority patent/GB9508959D0/en
Priority claimed from GBGB9508964.5A external-priority patent/GB9508964D0/en
Application filed by SMIHKLINE BEECHAM PLC filed Critical SMIHKLINE BEECHAM PLC
Publication of CN1184480A publication Critical patent/CN1184480A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
CN96194015A 1995-05-03 1996-05-02 碳代青霉烯酯 Pending CN1184480A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9508960.3A GB9508960D0 (en) 1995-05-03 1995-05-03 Novel compounds
GB9508959.5 1995-05-03
GBGB9508959.5A GB9508959D0 (en) 1995-05-03 1995-05-03 Novel compounds
GBGB9508964.5A GB9508964D0 (en) 1995-05-03 1995-05-03 Novel compounds
GB9508960.3 1995-05-03
GB9508964.5 1995-05-03

Publications (1)

Publication Number Publication Date
CN1184480A true CN1184480A (zh) 1998-06-10

Family

ID=27267697

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96194015A Pending CN1184480A (zh) 1995-05-03 1996-05-02 碳代青霉烯酯

Country Status (14)

Country Link
EP (1) EP0823911A1 (tr)
JP (1) JPH11504912A (tr)
KR (1) KR19990008354A (tr)
CN (1) CN1184480A (tr)
AU (1) AU5814196A (tr)
BR (1) BR9608318A (tr)
CA (1) CA2217885A1 (tr)
CZ (1) CZ347697A3 (tr)
HU (1) HUP9801061A3 (tr)
MX (1) MX9708422A (tr)
NO (1) NO974995L (tr)
PL (1) PL323148A1 (tr)
TR (1) TR199701289T2 (tr)
WO (1) WO1996034869A1 (tr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100771019B1 (ko) * 2002-03-20 2007-10-29 주식회사 만도 브레이크 액압제어장치
GB0400329D0 (en) * 2004-01-08 2004-02-11 Glaxo Group Ltd Novel processes
GB0400405D0 (en) * 2004-01-09 2004-02-11 Glaxo Group Ltd Novel processes
JP2007039383A (ja) * 2005-08-03 2007-02-15 Dainippon Sumitomo Pharma Co Ltd アリールカルバペネム化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
DK637888A (da) * 1987-11-24 1989-05-25 Hoffmann La Roche Carboxylsyreestere
GB8809534D0 (en) * 1988-04-22 1988-05-25 Beecham Group Plc Novel compounds
SK53696A3 (en) * 1993-10-29 1996-10-02 Smithkline Beecham Plc Carbapenem derivatives, their preparation, pharmaceutical compositions containing them and their use

Also Published As

Publication number Publication date
CZ347697A3 (cs) 1998-06-17
MX9708422A (es) 1998-02-28
TR199701289T2 (tr) 1998-08-21
BR9608318A (pt) 1999-01-26
AU5814196A (en) 1996-11-21
JPH11504912A (ja) 1999-05-11
NO974995D0 (no) 1997-10-30
KR19990008354A (ko) 1999-01-25
HUP9801061A2 (hu) 1998-08-28
HUP9801061A3 (en) 1999-01-28
PL323148A1 (en) 1998-03-16
EP0823911A1 (en) 1998-02-18
CA2217885A1 (en) 1996-11-07
WO1996034869A1 (en) 1996-11-07
NO974995L (no) 1997-10-30

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication