CA2217885A1 - Esters of carbapenems - Google Patents

Esters of carbapenems Download PDF

Info

Publication number
CA2217885A1
CA2217885A1 CA002217885A CA2217885A CA2217885A1 CA 2217885 A1 CA2217885 A1 CA 2217885A1 CA 002217885 A CA002217885 A CA 002217885A CA 2217885 A CA2217885 A CA 2217885A CA 2217885 A1 CA2217885 A1 CA 2217885A1
Authority
CA
Canada
Prior art keywords
group
alkyl
formula
compound
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002217885A
Other languages
English (en)
French (fr)
Inventor
Alfred John Eglington
Stephen Frederick Moss
Stephen Christopher Martin Fell
George Burton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9508960.3A external-priority patent/GB9508960D0/en
Priority claimed from GBGB9508959.5A external-priority patent/GB9508959D0/en
Priority claimed from GBGB9508964.5A external-priority patent/GB9508964D0/en
Application filed by Individual filed Critical Individual
Publication of CA2217885A1 publication Critical patent/CA2217885A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
CA002217885A 1995-05-03 1996-05-02 Esters of carbapenems Abandoned CA2217885A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9508960.3A GB9508960D0 (en) 1995-05-03 1995-05-03 Novel compounds
GB9508959.5 1995-05-03
GBGB9508959.5A GB9508959D0 (en) 1995-05-03 1995-05-03 Novel compounds
GBGB9508964.5A GB9508964D0 (en) 1995-05-03 1995-05-03 Novel compounds
GB9508960.3 1995-05-03
GB9508964.5 1995-05-03

Publications (1)

Publication Number Publication Date
CA2217885A1 true CA2217885A1 (en) 1996-11-07

Family

ID=27267697

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002217885A Abandoned CA2217885A1 (en) 1995-05-03 1996-05-02 Esters of carbapenems

Country Status (14)

Country Link
EP (1) EP0823911A1 (tr)
JP (1) JPH11504912A (tr)
KR (1) KR19990008354A (tr)
CN (1) CN1184480A (tr)
AU (1) AU5814196A (tr)
BR (1) BR9608318A (tr)
CA (1) CA2217885A1 (tr)
CZ (1) CZ347697A3 (tr)
HU (1) HUP9801061A3 (tr)
MX (1) MX9708422A (tr)
NO (1) NO974995L (tr)
PL (1) PL323148A1 (tr)
TR (1) TR199701289T2 (tr)
WO (1) WO1996034869A1 (tr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100771019B1 (ko) * 2002-03-20 2007-10-29 주식회사 만도 브레이크 액압제어장치
GB0400329D0 (en) * 2004-01-08 2004-02-11 Glaxo Group Ltd Novel processes
GB0400405D0 (en) * 2004-01-09 2004-02-11 Glaxo Group Ltd Novel processes
JP2007039383A (ja) * 2005-08-03 2007-02-15 Dainippon Sumitomo Pharma Co Ltd アリールカルバペネム化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
DK637888A (da) * 1987-11-24 1989-05-25 Hoffmann La Roche Carboxylsyreestere
GB8809534D0 (en) * 1988-04-22 1988-05-25 Beecham Group Plc Novel compounds
SK53696A3 (en) * 1993-10-29 1996-10-02 Smithkline Beecham Plc Carbapenem derivatives, their preparation, pharmaceutical compositions containing them and their use

Also Published As

Publication number Publication date
CZ347697A3 (cs) 1998-06-17
CN1184480A (zh) 1998-06-10
MX9708422A (es) 1998-02-28
TR199701289T2 (tr) 1998-08-21
BR9608318A (pt) 1999-01-26
AU5814196A (en) 1996-11-21
JPH11504912A (ja) 1999-05-11
NO974995D0 (no) 1997-10-30
KR19990008354A (ko) 1999-01-25
HUP9801061A2 (hu) 1998-08-28
HUP9801061A3 (en) 1999-01-28
PL323148A1 (en) 1998-03-16
EP0823911A1 (en) 1998-02-18
WO1996034869A1 (en) 1996-11-07
NO974995L (no) 1997-10-30

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Legal Events

Date Code Title Description
FZDE Discontinued