CN115605460A - 杂环化合物的合成 - Google Patents

杂环化合物的合成 Download PDF

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Publication number
CN115605460A
CN115605460A CN202180031962.1A CN202180031962A CN115605460A CN 115605460 A CN115605460 A CN 115605460A CN 202180031962 A CN202180031962 A CN 202180031962A CN 115605460 A CN115605460 A CN 115605460A
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formula
compound
acid
salt
alkyl
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Chinese (zh)
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J.林
J.沃尔特斯
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Plexxikon Inc
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Plexxikon Inc
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Publication of CN115605460A publication Critical patent/CN115605460A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN202180031962.1A 2020-04-29 2021-04-28 杂环化合物的合成 Pending CN115605460A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063017587P 2020-04-29 2020-04-29
US63/017,587 2020-04-29
PCT/US2021/029699 WO2021222442A1 (en) 2020-04-29 2021-04-28 Synthesis of heterocyclic compounds

Publications (1)

Publication Number Publication Date
CN115605460A true CN115605460A (zh) 2023-01-13

Family

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CN202180031962.1A Pending CN115605460A (zh) 2020-04-29 2021-04-28 杂环化合物的合成

Country Status (11)

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US (3) US11739088B2 (enExample)
EP (1) EP4143168A1 (enExample)
JP (1) JP7885132B2 (enExample)
KR (1) KR20230028254A (enExample)
CN (1) CN115605460A (enExample)
AU (1) AU2021263383A1 (enExample)
BR (1) BR112022021920A2 (enExample)
CA (1) CA3176237A1 (enExample)
IL (1) IL297645B2 (enExample)
MX (1) MX2022013597A (enExample)
WO (1) WO2021222442A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025026050A1 (zh) * 2023-07-28 2025-02-06 苏州科睿思制药有限公司 Bezuclastinib的晶型及其制备方法和用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021263383A1 (en) 2020-04-29 2022-11-24 Plexxikon Inc. Synthesis of heterocyclic compounds

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US4439368A (en) * 1982-09-29 1984-03-27 Union Carbide Corporation One solvent process for preparation of esters of 3,5-dibromo-4-hydroxybenzonitrile
FR2560872A1 (fr) * 1984-03-09 1985-09-13 Union Carbide Corp Procede utilisant un seul solvant pour la preparation d'esters de 3,5-dibromo-4-hydroxybenzonitrile
GB2155008A (en) * 1984-02-29 1985-09-18 Union Carbide Corp One solvent process for preparation of esters of 3,5-dibromo-4-hydroxybenzonitrile
CA1208655A (en) * 1984-02-29 1986-07-29 Richard E. Sheads One solvent process for preparation of esters of 3,5- dibromo-4- hydroxybenzonitrile
US4980493A (en) * 1986-03-13 1990-12-25 Ici Australia Limited Process for preparing benzonitriles
CN105308036A (zh) * 2012-12-21 2016-02-03 普莱希科公司 用于激酶调节的化合物和方法及其适应症
CN118108629A (zh) * 2024-01-11 2024-05-31 浙江禾本科技股份有限公司 一种丁酰溴苯腈的合成方法

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WO2025026050A1 (zh) * 2023-07-28 2025-02-06 苏州科睿思制药有限公司 Bezuclastinib的晶型及其制备方法和用途

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