CA3176237A1 - Synthesis of heterocyclic compounds - Google Patents

Synthesis of heterocyclic compounds Download PDF

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Publication number
CA3176237A1
CA3176237A1 CA3176237A CA3176237A CA3176237A1 CA 3176237 A1 CA3176237 A1 CA 3176237A1 CA 3176237 A CA3176237 A CA 3176237A CA 3176237 A CA3176237 A CA 3176237A CA 3176237 A1 CA3176237 A1 CA 3176237A1
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CA
Canada
Prior art keywords
formula
compound
salt
mmol
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3176237A
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English (en)
French (fr)
Inventor
Jack Lin
Jason WALTERS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Plexxikon Inc
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA3176237A1 publication Critical patent/CA3176237A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA3176237A 2020-04-29 2021-04-28 Synthesis of heterocyclic compounds Pending CA3176237A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063017587P 2020-04-29 2020-04-29
US63/017,587 2020-04-29
PCT/US2021/029699 WO2021222442A1 (en) 2020-04-29 2021-04-28 Synthesis of heterocyclic compounds

Publications (1)

Publication Number Publication Date
CA3176237A1 true CA3176237A1 (en) 2021-11-04

Family

ID=76012017

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3176237A Pending CA3176237A1 (en) 2020-04-29 2021-04-28 Synthesis of heterocyclic compounds

Country Status (11)

Country Link
US (3) US11739088B2 (enExample)
EP (1) EP4143168A1 (enExample)
JP (1) JP7885132B2 (enExample)
KR (1) KR20230028254A (enExample)
CN (1) CN115605460A (enExample)
AU (1) AU2021263383A1 (enExample)
BR (1) BR112022021920A2 (enExample)
CA (1) CA3176237A1 (enExample)
IL (1) IL297645B2 (enExample)
MX (1) MX2022013597A (enExample)
WO (1) WO2021222442A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021263383A1 (en) 2020-04-29 2022-11-24 Plexxikon Inc. Synthesis of heterocyclic compounds
KR20260066052A (ko) * 2023-07-28 2026-05-12 코젠트 바이오사이언시스, 인크. 베주클라스티닙의 결정형, 이의 제조방법 및 이의 용도

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Also Published As

Publication number Publication date
US12435086B2 (en) 2025-10-07
IL297645B2 (en) 2026-01-01
CN115605460A (zh) 2023-01-13
KR20230028254A (ko) 2023-02-28
US20260209227A1 (en) 2026-07-23
IL297645B1 (en) 2025-09-01
US20240217965A1 (en) 2024-07-04
US11739088B2 (en) 2023-08-29
MX2022013597A (es) 2023-03-22
WO2021222442A1 (en) 2021-11-04
US20210340139A1 (en) 2021-11-04
JP7885132B2 (ja) 2026-07-06
AU2021263383A1 (en) 2022-11-24
EP4143168A1 (en) 2023-03-08
JP2023524465A (ja) 2023-06-12
IL297645A (en) 2022-12-01
BR112022021920A2 (pt) 2023-01-17

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