JP2023524465A5 - - Google Patents

Info

Publication number
JP2023524465A5
JP2023524465A5 JP2022566118A JP2022566118A JP2023524465A5 JP 2023524465 A5 JP2023524465 A5 JP 2023524465A5 JP 2022566118 A JP2022566118 A JP 2022566118A JP 2022566118 A JP2022566118 A JP 2022566118A JP 2023524465 A5 JP2023524465 A5 JP 2023524465A5
Authority
JP
Japan
Prior art keywords
formula
compound
salt
acid
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022566118A
Other languages
English (en)
Japanese (ja)
Other versions
JP7885132B2 (ja
JP2023524465A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/029699 external-priority patent/WO2021222442A1/en
Publication of JP2023524465A publication Critical patent/JP2023524465A/ja
Publication of JP2023524465A5 publication Critical patent/JP2023524465A5/ja
Application granted granted Critical
Publication of JP7885132B2 publication Critical patent/JP7885132B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022566118A 2020-04-29 2021-04-28 複素環式化合物の合成 Active JP7885132B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063017587P 2020-04-29 2020-04-29
US63/017,587 2020-04-29
PCT/US2021/029699 WO2021222442A1 (en) 2020-04-29 2021-04-28 Synthesis of heterocyclic compounds

Publications (3)

Publication Number Publication Date
JP2023524465A JP2023524465A (ja) 2023-06-12
JP2023524465A5 true JP2023524465A5 (enExample) 2025-10-08
JP7885132B2 JP7885132B2 (ja) 2026-07-06

Family

ID=76012017

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022566118A Active JP7885132B2 (ja) 2020-04-29 2021-04-28 複素環式化合物の合成

Country Status (11)

Country Link
US (3) US11739088B2 (enExample)
EP (1) EP4143168A1 (enExample)
JP (1) JP7885132B2 (enExample)
KR (1) KR20230028254A (enExample)
CN (1) CN115605460A (enExample)
AU (1) AU2021263383A1 (enExample)
BR (1) BR112022021920A2 (enExample)
CA (1) CA3176237A1 (enExample)
IL (1) IL297645B2 (enExample)
MX (1) MX2022013597A (enExample)
WO (1) WO2021222442A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021263383A1 (en) 2020-04-29 2022-11-24 Plexxikon Inc. Synthesis of heterocyclic compounds
KR20260066052A (ko) * 2023-07-28 2026-05-12 코젠트 바이오사이언시스, 인크. 베주클라스티닙의 결정형, 이의 제조방법 및 이의 용도

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4436665A (en) * 1982-09-29 1984-03-13 Union Carbide Corporation Two solvent process for preparation of esters of 3,5-dibromo-4-hydroxybenzonitrile
US4439368A (en) * 1982-09-29 1984-03-27 Union Carbide Corporation One solvent process for preparation of esters of 3,5-dibromo-4-hydroxybenzonitrile
GB2155008B (en) * 1984-02-29 1987-12-02 Union Carbide Corp One solvent process for preparation of esters of 3,5-dibromo-4-hydroxybenzonitrile
CA1208655A (en) * 1984-02-29 1986-07-29 Richard E. Sheads One solvent process for preparation of esters of 3,5- dibromo-4- hydroxybenzonitrile
FR2560872B1 (fr) * 1984-03-09 1986-11-21 Union Carbide Corp Procede utilisant un seul solvant pour la preparation d'esters de 3,5-dibromo-4-hydroxybenzonitrile
FR2597095B1 (fr) * 1986-03-13 1990-07-20 Ici Australia Ltd Procede de production d'alkanoates de 2,6 dibromo ou iodo 4-cyano-phenyles
US7078391B2 (en) 1997-02-10 2006-07-18 Inspire Pharmaceuticals, Inc. Method of treating edematous retinal disorders
GB9824310D0 (en) 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
CA2395461C (en) 1999-12-22 2010-05-25 Sugen, Inc. Methods of modulating c-kit tyrosine kinase function with indolinone compounds
US6743817B2 (en) 2000-09-06 2004-06-01 Neurogen Corporation Substituted fused pyrroleimines and pyrazoleimines
US20040171062A1 (en) 2002-02-28 2004-09-02 Plexxikon, Inc. Methods for the design of molecular scaffolds and ligands
EP1495016A2 (en) 2002-04-09 2005-01-12 Astex Technology Limited Heterocyclic compounds and their use as modulators of p38 map kinase
GB0218625D0 (en) 2002-08-10 2002-09-18 Astex Technology Ltd Pharmaceutical compounds
KR20140070676A (ko) 2002-09-06 2014-06-10 인설트 테라페틱스, 인코퍼레이티드 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체
AU2003272548A1 (en) 2002-09-16 2004-04-30 Plexxikon, Inc. Crystal structure of pim-1 kinase
FR2845382A1 (fr) 2002-10-02 2004-04-09 Sanofi Synthelabo Derives d'indazolecarboxamides, leur preparation et leur utilisation en therapeutique
US20050048573A1 (en) 2003-02-03 2005-03-03 Plexxikon, Inc. PDE5A crystal structure and uses
EP1627045A2 (en) 2003-02-28 2006-02-22 Plexxikon, Inc. Pyk2 crystal structure and uses
US20050004133A1 (en) 2003-06-05 2005-01-06 Makings Lewis R. Modulators of VR1 receptor
US20050079548A1 (en) 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
US7348338B2 (en) 2003-07-17 2008-03-25 Plexxikon, Inc. PPAR active compounds
BRPI0412684A (pt) 2003-07-17 2006-10-03 Plexxinko Inc compostos ppar-ativos
US7442709B2 (en) 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
AP2006003552A0 (en) 2003-08-21 2006-04-30 Osi Pharm Inc N3 - substituted imidazopyridine C-kit inhibitors.
WO2005028624A2 (en) 2003-09-15 2005-03-31 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
JP5138938B2 (ja) 2003-12-19 2013-02-06 プレキシコン インコーポレーテッド Ｒｅｔ調節剤の開発のための化合物および方法
US7517970B2 (en) 2003-12-19 2009-04-14 Plexxikon, Inc. Nucleic acids encoding kinase and phosphatase enzymes, expression vectors and cells containing same
US20070066641A1 (en) 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
GB0330043D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
US7452730B2 (en) 2004-01-16 2008-11-18 California Institute Of Technology DNA-binding polymers
WO2005094805A1 (ja) 2004-04-01 2005-10-13 Institute Of Medicinal Molecular Design. Inc. イミン誘導体及びアミド誘導体
JP2008503446A (ja) 2004-05-06 2008-02-07 プレキシコン，インコーポレーテッド Ｐｄｅ４ｂ阻害剤及びその使用
TW200616632A (en) 2004-06-17 2006-06-01 Plexxikon Inc Compounds modulating c-kit activity and uses therefor
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
CN101048407A (zh) 2004-09-03 2007-10-03 普莱希科公司 双环杂芳基pde4b抑制剂
WO2006032851A1 (en) 2004-09-20 2006-03-30 Biolipox Ab Pyrazole compounds useful in the treatment of inflammation
AU2005311826A1 (en) 2004-11-30 2006-06-08 Plexxikon, Inc. Indole derivatives for use as PPAR active compounds
EP1819673A2 (en) 2004-11-30 2007-08-22 Plexxikon, Inc. Indole derivatives for use as ppar active compounds
US20060160135A1 (en) 2004-12-08 2006-07-20 Weiru Wang SF-1 and LRH-1 modulator development
WO2006077425A1 (en) 2005-01-21 2006-07-27 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors and further antitumor agents
AU2006272951A1 (en) 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
MY153898A (en) 2005-06-22 2015-04-15 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
US20100234379A1 (en) 2005-07-28 2010-09-16 Bahr Ben A Dual modulation of endocannabinoid transport and fatty-acid amide hydrolase for treatment of excitotoxicity
US7754717B2 (en) 2005-08-15 2010-07-13 Amgen Inc. Bis-aryl amide compounds and methods of use
CA2621474A1 (en) 2005-09-07 2007-03-15 Plexxikon, Inc. 1,3-disubstituted indole derivatives for use as ppar modulators
CA2621275A1 (en) 2005-09-07 2007-03-15 Plexxikon, Inc. 1 , 4 and 1 , 5-disubstituted indole derivatives for use as ppar active compounds
CA2621406A1 (en) 2005-09-07 2007-03-15 Plexxikon, Inc. Pparactive compounds
TW200732320A (en) 2005-10-31 2007-09-01 Biolipox Ab Pyrazoles useful in the treatment of inflammation
PE20080888A1 (es) 2006-10-18 2008-08-26 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE LA ACIL-TRANSFERASA DE ACIL-CoA-DIACIL-GLICEROL 1 (DGAT1)
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
RU2009122670A (ru) 2006-12-21 2011-01-27 Плекссикон, Инк. (Us) Соединения и способы для модуляции киназ и показания к их применению
WO2008079909A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
WO2008079346A1 (en) 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
PE20121126A1 (es) 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
PE20090159A1 (es) 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
CN101668737A (zh) 2007-03-08 2010-03-10 普莱希科公司 Ppar活性化合物
WO2008112695A2 (en) 2007-03-12 2008-09-18 Irm Llc Pyrazolo [3,4-d] pyrimidines and 1, 2, 5, 6-tetraaza- as- indacenes as protein kinase inhibitors for cancer treatment
WO2008144253A1 (en) 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
US20090076275A1 (en) 2007-09-19 2009-03-19 David Robert Bolin Diacylglycerol acyltransferase inhibitors
WO2009073788A1 (en) 2007-12-07 2009-06-11 Firestone Leigh H Compositions and methods for treating menopausal females
WO2009112445A1 (en) 2008-03-10 2009-09-17 Novartis Ag Method of increasing cellular phosphatidyl choline by dgat1 inhibition
US8158636B2 (en) 2008-05-19 2012-04-17 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
PE20091846A1 (es) 2008-05-19 2009-12-16 Plexxikon Inc DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
US8110576B2 (en) 2008-06-10 2012-02-07 Plexxikon Inc. Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications
CN104530052A (zh) 2008-06-10 2015-04-22 普莱希科公司 用于激酶调节的5h-吡咯[2,3-b]吡嗪衍生物和其适应症
FR2941948B1 (fr) 2009-02-12 2013-04-05 Nova Decision Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
AR076105A1 (es) 2009-03-11 2011-05-18 Plexxikon Inc Derivados pirrol[2,3-b]piridina para inhibir la raf quinasa
AR075812A1 (es) 2009-03-11 2011-04-27 Plexxikon Inc Derivados de pirrol[2,3-b]piridina como inhibidores de raf quinasa
WO2010111527A1 (en) 2009-03-26 2010-09-30 Plexxikon, Inc. Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use
CA2738573C (en) 2009-04-03 2013-02-19 F. Hoffmann-La Roche Ag Compositions of propane-1 sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and uses thereof
SG175877A1 (en) 2009-05-04 2011-12-29 Plexxikon Inc Compounds and methods for inhibition of renin, and indications therefor
TW201041888A (en) 2009-05-06 2010-12-01 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
EP2471789B9 (en) 2009-08-26 2015-03-25 Takeda Pharmaceutical Company Limited Fused heterocyclic ring derivative and use thereof
JP2013510166A (ja) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド キナーゼ調節のための化合物、方法およびその適用
EP2501236B1 (en) 2009-11-18 2017-03-29 Plexxikon Inc. N-[2-fluoro-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-4-benzenesulfonamide derivatives as Raf protein kinase modulators for the treatment of cancer
CA2784393A1 (en) 2009-12-23 2011-06-30 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
CU24144B1 (es) 2010-01-04 2016-01-29 Nippon Soda Co Compuesto heterocíclico conteniendo nitrógeno y fungicida para el uso en agricultura y jardinería
WO2011116176A1 (en) 2010-03-17 2011-09-22 Sirtris Pharmaceuticals Inc. 3-substitued imidazo (4, 5-b) pyridines and analogs as sirtuin modulators
TWI510487B (zh) 2010-04-21 2015-12-01 Plexxikon Inc 用於激酶調節的化合物和方法及其適應症
US8642606B2 (en) 2010-09-29 2014-02-04 Plexxikon Inc. ZAP-70 active compounds
PE20141360A1 (es) 2011-02-07 2014-10-13 Plexxikon Inc Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
CA2836474A1 (en) 2011-05-17 2012-11-22 Plexxikon Inc. Kinase modulation and indications therefor
HUE041576T2 (hu) 2011-09-14 2019-05-28 Samumed Llc Indazol-3-karboxamid-származékok és alkalmazásuk Wnt/b-katenin szignalizáló útvonal inhibitorokként
US9358235B2 (en) 2012-03-19 2016-06-07 Plexxikon Inc. Kinase modulation, and indications therefor
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
JP6318156B2 (ja) 2012-09-06 2018-04-25 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． キナーゼをモジュレートするための化合物および方法、ならびにその指標
EP2738172A1 (en) * 2012-11-28 2014-06-04 Almirall, S.A. New bicyclic compounds as crac channel modulators
ME03000B (me) * 2012-12-21 2018-10-20 Plexxikon Inc Jedinjenja i metode modulacije kinaze i povezane indikacije
CN105073747B (zh) 2013-03-15 2017-06-06 普莱希科公司 杂环化合物及其应用
UY35400A (es) 2013-03-15 2014-10-31 Novartis Ag Compuestos y composiciones para el tratamiento de enfermedades parasitarias
US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
RU2015149937A (ru) 2013-05-30 2017-07-06 Плексксикон Инк. Соединения для модулирования киназы и показания к их применению
US9771369B2 (en) 2014-03-04 2017-09-26 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
ES2774177T3 (es) 2014-09-15 2020-07-17 Plexxikon Inc Compuestos heterocíclicos y usos de estos
US10160755B2 (en) 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
SMT202000535T1 (it) 2015-05-06 2020-11-10 Plexxikon Inc Forme solide di composto modulante chinasi
CN112574196A (zh) 2015-05-06 2021-03-30 普莱希科公司 调节激酶的1H-吡咯并[2,3-b]吡啶衍生物的合成
HUE050936T2 (hu) 2015-05-22 2021-01-28 Plexxikon Inc Heterociklusos vegyületek szintézise
BR112017025045A2 (pt) 2015-05-22 2018-08-07 Plexxikon Inc plx-8394 ou plx-7904 para uso no tratamento de doenças relacionadas a braf-v600
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
HK1255102A1 (zh) 2015-09-21 2019-08-02 Plexxikon Inc. 杂环化合物及其应用
US9938273B2 (en) 2015-12-07 2018-04-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US10160747B2 (en) 2016-03-16 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
AU2021263383A1 (en) 2020-04-29 2022-11-24 Plexxikon Inc. Synthesis of heterocyclic compounds
CN118108629A (zh) * 2024-01-11 2024-05-31 浙江禾本科技股份有限公司 一种丁酰溴苯腈的合成方法

Similar Documents

Publication Publication Date Title
JP7179014B2 (ja) ニラパリブの製造方法
US6743920B2 (en) Process for imidazo[4,5-c]pyridin-4-amines
KR0146053B1 (ko) 3-피페리디닐-1,2-벤즈이속사졸
JP2021006559A (ja) 置換ヘテロ環縮合ガンマ−カルボリンの合成
ES2437755T3 (es) Intermedios para derivados de tienopirazol que tienen actividad inhibitoria de PDE 7
BR112014006660B1 (pt) Novos derivados de dihidroquinolina-2-ona bicíclicos
HU219911B (hu) Pirazolo-piridin-származékok, alkalmazásuk és ezeket tartalmazó gyógyászati készítmények
JP2007284451A (ja) ピペリジンｍｃｈアンタゴニストおよび肥満の処置におけるそれらの使用
CA3223210A1 (en) Novel ergolines and methods of treating mood disorders
EA023876B1 (ru) Бензодиоксановые ингибиторы продуцирования лейкотриена
US12435086B2 (en) Synthesis of heterocyclic compounds
KR20110011653A (ko) 테트라히드로이소퀴놀린의 제조 방법
CN101679353A (zh) 制备化合物2-羟基-3-[5-(吗啉-4-基甲基)吡啶-2-基]1h-吲哚-5-腈701的新方法
EP2707367B1 (en) Methods for preparing naphthyridines
CN102317289A (zh) 作为β分泌酶抑制剂的内酰胺
JP2008514713A (ja) ４，５−ジヒドロ−ピラゾロ［３，４−ｃ］ピリド−２−オン類の製造
JP2012515188A (ja) 抗菌薬として有用なナフチリジン―２（１ｈ）−オン化合物
KR0163413B1 (ko) 신경이완성 퍼하이드로-1H-피리도[1,2-a] 피라진
DK169517B1 (da) [Aryl](3-pyridinyl)methanon,oximderivater samt fremgangsmåde til fremstilling deraf
CN116848117B (zh) 作为Wee-1抑制剂的稠环化合物
EP1461338B1 (en) Improved process for the preparation of 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-2-methyl-4h-pyrido(1,2-a)pyrimidin-4-one
CN116867787A (zh) 吡唑并[3,4-d]嘧啶-3-酮衍生物
HK40087415A (en) Synthesis of heterocyclic compounds
KR101867988B1 (ko) 팔리페리돈 중간체 및 이를 이용한 팔리페리돈의 제조방법
KR960001200B1 (ko) 4-(아로일아미노)피페리딘부탄아미드 유도체의 제조방법