CN1152880C - 羟氢吗啡酮、羟氢可待酮及其衍生物的制备方法 - Google Patents

羟氢吗啡酮、羟氢可待酮及其衍生物的制备方法 Download PDF

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Publication number
CN1152880C
CN1152880C CNB988088169A CN98808816A CN1152880C CN 1152880 C CN1152880 C CN 1152880C CN B988088169 A CNB988088169 A CN B988088169A CN 98808816 A CN98808816 A CN 98808816A CN 1152880 C CN1152880 C CN 1152880C
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China
Prior art keywords
carbon atom
acid
mmol
benzyl
normorphine
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Expired - Fee Related
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CNB988088169A
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English (en)
Chinese (zh)
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CN1272845A (zh
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�����Ʊ���
黄宝善
G
A·柯瑞斯图督淕
陆岩松
嵇本一
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Penick Corp
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Penick Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CNB988088169A 1997-07-11 1998-07-10 羟氢吗啡酮、羟氢可待酮及其衍生物的制备方法 Expired - Fee Related CN1152880C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/893,464 1997-07-11
US08/893,464 US5869669A (en) 1996-07-26 1997-07-11 Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates

Publications (2)

Publication Number Publication Date
CN1272845A CN1272845A (zh) 2000-11-08
CN1152880C true CN1152880C (zh) 2004-06-09

Family

ID=25401603

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988088169A Expired - Fee Related CN1152880C (zh) 1997-07-11 1998-07-10 羟氢吗啡酮、羟氢可待酮及其衍生物的制备方法

Country Status (19)

Country Link
US (7) US5869669A (https=)
EP (1) EP1000065B1 (https=)
JP (1) JP2001518444A (https=)
KR (1) KR100363486B1 (https=)
CN (1) CN1152880C (https=)
AT (1) ATE291023T1 (https=)
AU (1) AU740822B2 (https=)
CA (1) CA2296035C (https=)
DE (1) DE69829379D1 (https=)
HU (1) HUP0003918A3 (https=)
IL (1) IL133792A0 (https=)
IN (1) IN1998KO01500A (https=)
NO (1) NO20000111L (https=)
RU (1) RU2183636C2 (https=)
SK (1) SK102000A3 (https=)
TR (1) TR200000033T2 (https=)
TW (1) TW505648B (https=)
WO (1) WO1999002529A1 (https=)
ZA (1) ZA986144B (https=)

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Also Published As

Publication number Publication date
EP1000065B1 (en) 2005-03-16
KR20010021693A (ko) 2001-03-15
US5952495A (en) 1999-09-14
ATE291023T1 (de) 2005-04-15
DE69829379D1 (de) 2005-04-21
NO20000111L (no) 2000-02-25
US5869669A (en) 1999-02-09
TR200000033T2 (tr) 2000-12-21
US5922876A (en) 1999-07-13
AU740822B2 (en) 2001-11-15
AU8379198A (en) 1999-02-08
EP1000065A4 (en) 2001-09-12
HUP0003918A3 (en) 2003-04-28
SK102000A3 (en) 2000-07-11
IL133792A0 (en) 2001-04-30
EP1000065A1 (en) 2000-05-17
RU2183636C2 (ru) 2002-06-20
CA2296035A1 (en) 1999-01-21
US6008355A (en) 1999-12-28
CA2296035C (en) 2004-04-13
US6008354A (en) 1999-12-28
WO1999002529A1 (en) 1999-01-21
HK1028025A1 (en) 2001-02-02
TW505648B (en) 2002-10-11
ZA986144B (en) 1999-05-19
NO20000111D0 (no) 2000-01-10
US6013796A (en) 2000-01-11
IN1998KO01500A (https=) 2005-03-11
CN1272845A (zh) 2000-11-08
US5948788A (en) 1999-09-07
KR100363486B1 (ko) 2002-12-16
HUP0003918A2 (hu) 2001-07-30
JP2001518444A (ja) 2001-10-16

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