|
US5912347A
(en)
*
|
1996-09-30 |
1999-06-15 |
Mallinckrodt Inc. |
Process for preparing a morphinan derivative
|
|
WO2000066588A1
(en)
*
|
1999-05-05 |
2000-11-09 |
The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services |
Direct c-14 oxidation of opioids
|
|
US6177567B1
(en)
*
|
1999-10-15 |
2001-01-23 |
Boehringer Ingelheim Chemicals, Inc. |
Method for preparing oxycodone
|
|
PL368732A1
(en)
*
|
2001-08-23 |
2005-04-04 |
Akzo Nobel N.V. |
C-14 oxidation of morphine derivatives
|
|
JP3961796B2
(ja)
*
|
2001-08-27 |
2007-08-22 |
ソニー株式会社 |
情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム
|
|
DE10161963A1
(de)
*
|
2001-12-17 |
2003-07-03 |
Johannes Schuetz |
6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
|
|
US20040001889A1
(en)
|
2002-06-25 |
2004-01-01 |
Guohua Chen |
Short duration depot formulations
|
|
US20040058946A1
(en)
*
|
2002-07-05 |
2004-03-25 |
Buchwald Stephen L. |
Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
|
|
RU2236412C2
(ru)
*
|
2002-07-18 |
2004-09-20 |
Власов Михаил Иванович |
Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона
|
|
RU2215742C1
(ru)
*
|
2002-11-05 |
2003-11-10 |
Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" |
Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
|
|
RU2215741C1
(ru)
*
|
2002-11-05 |
2003-11-10 |
Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" |
Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
|
|
EP1562953B1
(en)
*
|
2002-11-08 |
2009-09-30 |
Mallinckrodt Inc. |
Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
|
|
ATE482695T1
(de)
|
2002-12-13 |
2010-10-15 |
Durect Corp |
Orale darreichungsform mit flüssigen hochviskosen trägersystemen
|
|
US6790959B1
(en)
|
2003-06-05 |
2004-09-14 |
Halsey Drug Company, Inc. |
Process for manufacturing thebaine
|
|
US6864370B1
(en)
|
2003-06-05 |
2005-03-08 |
Zhaiwei Lin |
Process for manufacturing oxycodone
|
|
US7875718B2
(en)
*
|
2003-09-22 |
2011-01-25 |
Johnson Matthey Public Limited Company |
Process for the synthesis of morphinane compounds and intermediates thereof
|
|
CA2539659C
(en)
|
2003-09-22 |
2013-03-26 |
Johnson Matthey Public Limited Company |
Process for the synthesis of morphinane compounds and intermediates thereof
|
|
EA012905B1
(ru)
|
2004-02-06 |
2010-02-26 |
Еуро-Селтик С.А. |
Способы получения 3-о-защищенных морфинов и 3-о-защищенных морфинондиенолкарбоксилатов
|
|
TW201509943A
(zh)
|
2004-03-30 |
2015-03-16 |
Euro Celtique Sa |
含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
|
|
SK286047B6
(sk)
*
|
2004-04-13 |
2008-01-07 |
Zentiva, A. S. |
Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
|
|
US6946556B1
(en)
*
|
2004-05-21 |
2005-09-20 |
Acura Pharmaceuticals, Inc. |
Preparation of opioid analgesics by a one-pot process
|
|
AU2005254933B2
(en)
*
|
2004-06-08 |
2010-08-19 |
Mallinckrodt Inc. |
Extraction of alkaloids from opium
|
|
CA2916869A1
(en)
|
2004-06-12 |
2005-12-29 |
Jane C. Hirsh |
Abuse-deterrent drug formulations
|
|
AU2005287175B2
(en)
|
2004-09-17 |
2011-12-01 |
Durect Corporation |
Sustained local anesthetic composition containing preferably a sugar ester such as SAIB
|
|
GB0421149D0
(en)
*
|
2004-09-23 |
2004-10-27 |
Johnson Matthey Plc |
Preparation of oxycodone
|
|
GB0421687D0
(en)
*
|
2004-09-30 |
2004-11-03 |
Johnson Matthey Plc |
Preparation of opiate analgesics
|
|
WO2006084389A1
(de)
*
|
2005-02-11 |
2006-08-17 |
Cilag Ltd. |
Verfahren zur reinigung von noroxymorphon-verbindungen
|
|
ME01594B
(me)
*
|
2005-03-04 |
2014-09-20 |
Euro Celtique Sa |
Postupak smanjenja alfa, beta nezasićenih ketona u opioidnim kompozicijama
|
|
WO2006109671A1
(ja)
*
|
2005-04-06 |
2006-10-19 |
Toray Industries, Inc. |
モルヒナン誘導体の結晶及びその製造法
|
|
US8071768B2
(en)
*
|
2005-06-10 |
2011-12-06 |
Janssen Pharmaceutica, N.V. |
Alkylquinoline and alkylquinazoline kinase modulators
|
|
ES2357216T3
(es)
*
|
2005-06-16 |
2011-04-20 |
Mallinckrodt, Inc. |
Una ruta de síntesis de 14-hidroxil-opiáceos a través de 1-halo-tebaína o análogos.
|
|
US20070027105A1
(en)
|
2005-07-26 |
2007-02-01 |
Alza Corporation |
Peroxide removal from drug delivery vehicle
|
|
US20070117826A1
(en)
*
|
2005-11-23 |
2007-05-24 |
Forest Laboratories, Inc. |
Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
|
|
CN101395159A
(zh)
|
2006-03-02 |
2009-03-25 |
马林克罗特公司 |
制备含有低含量α,β-不饱和酮化合物的吗啡烷-6-酮产物的方法
|
|
SA07280459B1
(ar)
|
2006-08-25 |
2011-07-20 |
بيورديو فارما إل. بي. |
أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
|
|
EP2099764B1
(en)
*
|
2006-09-20 |
2011-07-27 |
Mallinckrodt Inc. |
Preparation of substituted morphinan-6-ones and salts and intermediates thereof
|
|
AU2007313103C1
(en)
|
2006-10-17 |
2014-01-30 |
Penick Corporation |
Process for preparing oxymorphone
|
|
US20080125592A1
(en)
*
|
2006-10-17 |
2008-05-29 |
Penick Corporation |
Process for preparing oxymorphone, naltrexone, and buprenorphine
|
|
CA2674915C
(en)
|
2006-10-17 |
2015-06-30 |
Penick Corporation |
Process for preparing oxymorphone
|
|
AU2012216358B2
(en)
*
|
2006-10-17 |
2014-11-20 |
Penick Corporation |
Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
|
|
US8337883B2
(en)
|
2006-11-03 |
2012-12-25 |
Durect Corporation |
Transdermal delivery systems
|
|
ES2393221T3
(es)
*
|
2006-12-04 |
2012-12-19 |
Noramco, Inc. |
Procedimiento de preparación de oxicodona con niveles reducidos de 14-hidroxicodeinona
|
|
WO2008070656A2
(en)
*
|
2006-12-04 |
2008-06-12 |
Noramco, Inc |
Process for reducing impurities in oxycodone base
|
|
GB0624880D0
(en)
*
|
2006-12-14 |
2007-01-24 |
Johnson Matthey Plc |
Improved method for making analgesics
|
|
EP2137189B1
(en)
*
|
2007-03-06 |
2015-05-06 |
Mallinckrodt LLC |
Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
|
|
US9040726B2
(en)
|
2007-03-06 |
2015-05-26 |
Mallinckrodt Llc |
Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
|
|
ES2438997T5
(es)
*
|
2007-03-23 |
2024-09-03 |
SpecGx LLC |
Preparación mejorada de oximorfona a partir de oripavina
|
|
CA2684458A1
(en)
*
|
2007-04-16 |
2008-10-30 |
Mallinckrodt Inc. |
Novel opiate reduction utilizing catalytic hydrogen transfer reaction
|
|
US20090018154A1
(en)
*
|
2007-05-17 |
2009-01-15 |
Endo Pharmaceuticals, Inc., A Corporation Of Delaware |
Opioid and methods of making and using the same
|
|
EP2219622A1
(en)
|
2007-12-06 |
2010-08-25 |
Durect Corporation |
Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition
|
|
WO2009079013A1
(en)
*
|
2007-12-17 |
2009-06-25 |
Mallinckrodt Inc. |
Processes for the production of (+)-'nal' morphinan compounds
|
|
US8461337B2
(en)
|
2007-12-17 |
2013-06-11 |
Mallinckrodt Llc |
Sinomenine derivatives and processes for their synthesis
|
|
EP2319845B1
(en)
|
2008-02-29 |
2013-07-24 |
Mallinckrodt LLC |
3-Hydroxymorphinan derivatives
|
|
CA2722246C
(en)
*
|
2008-04-24 |
2016-06-21 |
Janssen Pharmaceutica Nv |
Nalmefene prodrugs
|
|
US8148528B2
(en)
*
|
2008-05-27 |
2012-04-03 |
Mallinckrodt Llc |
Processes and compounds for the preparation of normorphinans
|
|
EP2331508B1
(en)
|
2008-09-03 |
2014-11-12 |
Mallinckrodt LLC |
Substituted berbines and processes for their synthesis
|
|
CA2738246C
(en)
*
|
2008-09-30 |
2017-09-05 |
Mallinckrodt Inc. |
Processes for the alkylation of secondary amine groups of morphinan derivatives
|
|
US20100260844A1
(en)
|
2008-11-03 |
2010-10-14 |
Scicinski Jan J |
Oral pharmaceutical dosage forms
|
|
UA102916C2
(uk)
|
2009-07-02 |
2013-08-27 |
Кемфарм, Інк. |
Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
|
|
US10668060B2
(en)
|
2009-12-10 |
2020-06-02 |
Collegium Pharmaceutical, Inc. |
Tamper-resistant pharmaceutical compositions of opioids and other drugs
|
|
EP2580201B1
(en)
|
2010-06-11 |
2017-08-02 |
Rhodes Technologies |
Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
|
|
CA2802294C
(en)
|
2010-06-11 |
2016-05-10 |
Rhodes Technologies |
Process for n-dealkylation of tertiary amines
|
|
PL2588481T3
(pl)
|
2010-07-02 |
2018-05-30 |
Johnson Matthey Public Limited Company |
Sposób syntezy i oczyszczania oksykodonu
|
|
RU2448709C1
(ru)
*
|
2011-02-01 |
2012-04-27 |
Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) |
Способ получения налтрексона
|
|
TWI560170B
(en)
*
|
2011-12-06 |
2016-12-01 |
Lundbeck & Co As H |
Process for recovery of nalmefene hydrochloride
|
|
US9315514B2
(en)
|
2012-08-27 |
2016-04-19 |
Rhodes Technologies |
1,3-dioxanomorphides and 1,3-dioxanocodides
|
|
WO2014091297A1
(en)
|
2012-12-14 |
2014-06-19 |
Purdue Pharma L.P. |
Spirocyclic morphinans and their use
|
|
EP2931724B1
(en)
|
2012-12-14 |
2017-01-25 |
Purdue Pharma LP |
Pyridonemorphinan analogs and biological activity on opioid receptors
|
|
ES2623262T3
(es)
|
2012-12-14 |
2017-07-10 |
Purdue Pharma Lp |
Derivados de morfinano que contienen nitrógeno y el uso de los mismos
|
|
US8946255B2
(en)
|
2012-12-28 |
2015-02-03 |
Purdue Pharma L.P. |
Substituted morphinans and the use thereof
|
|
WO2014102587A1
(en)
|
2012-12-28 |
2014-07-03 |
Purdue Pharma L.P. |
7,8-cyclicmorphinan analogs
|
|
AU2013369037C1
(en)
|
2012-12-31 |
2017-06-08 |
Rhodes Technologies |
Process for preparing 7beta-substituted 6alpha,14alpha -ethenomorphinans and 7beta-substituted 6alpha,14alpha-ethanomorphinans
|
|
TW201521769A
(zh)
|
2013-03-15 |
2015-06-16 |
Durect Corp |
具有流變改質劑以減少溶解變異性之組成物
|
|
EP2829541A1
(en)
|
2013-07-26 |
2015-01-28 |
Siegfried AG |
Novel synthesis of noroxymorphone from morphine
|
|
CA2919602C
(en)
|
2013-08-02 |
2018-03-13 |
Johnson Matthey Public Limited Company |
Process for the preparation of oxymorphone
|
|
WO2015097548A1
(en)
|
2013-12-26 |
2015-07-02 |
Purdue Pharma L.P. |
7-beta-alkyl analogs of orvinols
|
|
WO2015097547A1
(en)
|
2013-12-26 |
2015-07-02 |
Purdue Pharma L.P. |
10-substituted morphinan hydantoins
|
|
WO2015097546A1
(en)
|
2013-12-26 |
2015-07-02 |
Purdue Pharma L.P. |
Propellane-based compounds and their use as opioid receptor modulators
|
|
WO2015097545A1
(en)
|
2013-12-26 |
2015-07-02 |
Purdue Pharma L.P. |
Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
|
|
EP3089978B1
(en)
|
2013-12-30 |
2018-08-29 |
Purdue Pharma L.P. |
Pyridone-sulfone morphinan analogs as opioid receptor ligands
|
|
RU2683317C2
(ru)
*
|
2014-11-25 |
2019-03-28 |
Кемфарм, Инк. |
Конъюгаты оксикодона с бензойной кислотой, производными бензойной кислоты и гетероарилкарбоновой кислотой
|
|
EP3252055B1
(en)
|
2016-05-31 |
2018-09-19 |
Alcaliber Investigacion Desarrollo e Innovacion SLU |
Process for obtaining 3,14-diacetyloxymorphone from oripavine
|
|
US9737530B1
(en)
|
2016-06-23 |
2017-08-22 |
Collegium Pharmaceutical, Inc. |
Process of making stable abuse-deterrent oral formulations
|
|
SG11201811760VA
(en)
|
2016-07-06 |
2019-01-30 |
Durect Corp |
Oral dosage form with drug composition, barrier layer and drug layer
|
|
ES2926580T3
(es)
|
2016-12-23 |
2022-10-27 |
Minoryx Therapeutics S L |
Proceso para preparar 5-[[4-[2-[5-(1-hidroxietil)-2-piridinil]etoxi]fenil]metil]-2,4-tiazolidindiona y sales de la misma
|
|
SK592017A3
(sk)
|
2017-07-04 |
2019-01-08 |
Saneca Pharmaceuticals A. S. |
Spôsob prípravy morfínanových zlúčenín
|
|
AU2019224127B2
(en)
|
2018-02-23 |
2021-12-09 |
Rhodes Technologies |
Novel opioid compounds and uses thereof
|
|
CN110054656B
(zh)
*
|
2019-05-28 |
2021-02-02 |
宜昌人福药业有限责任公司 |
一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
|
|
EP3997092A4
(en)
*
|
2019-07-08 |
2023-09-06 |
University of Health Sciences & Pharmacy in St. Louis |
G-PROTEIN INFLUENCED OPIOID RECEPTOR AGONIST/ANALGESICS WITH REDUCED ARRESTIN RECRUITMENT
|
|
CN115666621A
(zh)
|
2020-01-13 |
2023-01-31 |
度勒科特公司 |
具有减少的杂质的持续释放药物递送系统及相关方法
|
|
CN114621239B
(zh)
*
|
2020-12-10 |
2026-02-03 |
鲁南制药集团股份有限公司 |
一种纳曲酮的制备方法
|
|
AU2021416361A1
(en)
*
|
2020-12-28 |
2023-06-08 |
Navin Saxena Research & Technology Pvt. Ltd. |
Novel process for the synthesis of noroxymorphone from morphine
|
|
CA3203561A1
(en)
|
2021-01-12 |
2022-07-21 |
Adrian Neil Verity |
Sustained release drug delivery systems and related methods
|