PL2588481T3 - Sposób syntezy i oczyszczania oksykodonu - Google Patents
Sposób syntezy i oczyszczania oksykodonuInfo
- Publication number
- PL2588481T3 PL2588481T3 PL11738337T PL11738337T PL2588481T3 PL 2588481 T3 PL2588481 T3 PL 2588481T3 PL 11738337 T PL11738337 T PL 11738337T PL 11738337 T PL11738337 T PL 11738337T PL 2588481 T3 PL2588481 T3 PL 2588481T3
- Authority
- PL
- Poland
- Prior art keywords
- oxycodone
- purification
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36115110P | 2010-07-02 | 2010-07-02 | |
| PCT/US2011/042834 WO2012003468A1 (en) | 2010-07-02 | 2011-07-01 | Process for the synthesis and purification of oxycodone |
| EP11738337.2A EP2588481B1 (en) | 2010-07-02 | 2011-07-01 | Process for the synthesis and purification of oxycodone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2588481T3 true PL2588481T3 (pl) | 2018-05-30 |
Family
ID=44358303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11738337T PL2588481T3 (pl) | 2010-07-02 | 2011-07-01 | Sposób syntezy i oczyszczania oksykodonu |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8703950B2 (pl) |
| EP (1) | EP2588481B1 (pl) |
| JP (1) | JP5988272B2 (pl) |
| AU (1) | AU2011274361B2 (pl) |
| CA (1) | CA2804101C (pl) |
| ES (1) | ES2659168T3 (pl) |
| GB (1) | GB2495062A (pl) |
| PL (1) | PL2588481T3 (pl) |
| WO (1) | WO2012003468A1 (pl) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI483944B (zh) | 2004-03-30 | 2015-05-11 | Euro Celtique Sa | 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
| AU2011274361B2 (en) * | 2010-07-02 | 2014-09-18 | Macfarlan Smith Limited | Process for the synthesis and purification of oxycodone |
| SG11201407988UA (en) * | 2012-07-16 | 2015-01-29 | Rhodes Technologies | Process for improved opioid synthesis |
| CA2879268C (en) * | 2012-07-16 | 2018-05-08 | Rhodes Technologies | Process for improved opioid synthesis |
| GB201313211D0 (en) | 2013-07-24 | 2013-09-04 | Cambrex Karlskoga Ab | New process |
| GB201313915D0 (en) * | 2013-08-02 | 2013-09-18 | Johnson Matthey Plc | Process |
| ES2741810T3 (es) * | 2013-11-07 | 2020-02-12 | SpecGx LLC | Producción de 6-hidroximorfinanos sin el aislamiento de intermedios |
| US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
| US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
| US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
| MX379406B (es) | 2014-01-15 | 2025-03-11 | Rhodes Tech | Proceso para la síntesis mejorada de oximorfona. |
| AU2015207733A1 (en) * | 2014-01-15 | 2016-07-14 | Rhodes Technologies | Process for improved oxycodone synthesis |
| US20160052932A1 (en) * | 2014-08-25 | 2016-02-25 | Johnson Matthey Public Limited Company | Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone |
| GB201513203D0 (en) | 2015-07-27 | 2015-09-09 | Cambrex Charles City Inc | New process |
| US10081636B2 (en) | 2016-07-08 | 2018-09-25 | Cody Laboratories, Inc. | Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates |
| CN113493460A (zh) * | 2020-03-20 | 2021-10-12 | 江苏恩华药业股份有限公司 | 盐酸羟考酮杂质b的制备方法 |
| CN113044998B (zh) * | 2021-03-26 | 2022-08-26 | 四川鸿康科技股份有限公司 | 一种锅炉给水药剂及其制备方法、应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE296916C (pl) | ||||
| US6067749A (en) | 1996-07-11 | 2000-05-30 | Tasmanian Alkaloids Pty. Ltd. | Papaver somniferum strain with high concentration of thebaine and oripavine |
| US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| GB9616253D0 (en) | 1996-08-01 | 1996-09-11 | Johnson Matthey Plc | Preparation of narcotic analgesics |
| ES2121554B1 (es) | 1996-12-23 | 1999-06-16 | Univ Santiago Compostela | Procedimiento de obtencion de 14-hidroximofinonas mediante fotooxidac ion de alcaloides morfinicos con sistema alcoxidienico en el anillo c. |
| GB9713703D0 (en) | 1997-06-30 | 1997-09-03 | Johnson Matthey Plc | Preparation of opiates |
| US6177567B1 (en) | 1999-10-15 | 2001-01-23 | Boehringer Ingelheim Chemicals, Inc. | Method for preparing oxycodone |
| US7534888B2 (en) | 2002-08-15 | 2009-05-19 | Noramco, Inc. | Oxycodone polymorphs |
| AU2004319925B2 (en) * | 2002-11-11 | 2010-12-09 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US7323565B2 (en) | 2002-11-11 | 2008-01-29 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US7321038B2 (en) * | 2002-11-11 | 2008-01-22 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| MXPA05005781A (es) | 2002-11-29 | 2005-12-12 | Forest Laboratories | Combinacion de ibuprofeno y oxicodona para alivio de dolor agudo. |
| US6864370B1 (en) | 2003-06-05 | 2005-03-08 | Zhaiwei Lin | Process for manufacturing oxycodone |
| TWI483944B (zh) | 2004-03-30 | 2015-05-11 | Euro Celtique Sa | 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
| SK286087B6 (sk) * | 2004-08-18 | 2008-03-05 | Zentiva, A. S. | Spôsob prípravy oxykodonu |
| GB0421149D0 (en) | 2004-09-23 | 2004-10-27 | Johnson Matthey Plc | Preparation of oxycodone |
| ATE493417T1 (de) * | 2005-06-16 | 2011-01-15 | Mallinckrodt Inc | Synthetische route zu 14-hydroxylopiaten über 1- halogenthebain oder analoga |
| CN101346384B (zh) * | 2005-11-22 | 2012-07-04 | 控制化学品公司 | 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法 |
| CN101395159A (zh) * | 2006-03-02 | 2009-03-25 | 马林克罗特公司 | 制备含有低含量α,β-不饱和酮化合物的吗啡烷-6-酮产物的方法 |
| JP2010511725A (ja) | 2006-12-04 | 2010-04-15 | ノランコ・インコーポレーテツド | オキシコドン塩基中の不純物を減少させる方法 |
| JP2010511726A (ja) | 2006-12-04 | 2010-04-15 | ノランコ・インコーポレーテツド | １４−ヒドロキシコデイノンの濃度が低いオキシコドンの製造方法 |
| JP5373764B2 (ja) | 2007-04-16 | 2013-12-18 | マリンクロッド エルエルシー | 触媒性水素転移反応を使用する新規なオピエート還元 |
| AU2011274361B2 (en) * | 2010-07-02 | 2014-09-18 | Macfarlan Smith Limited | Process for the synthesis and purification of oxycodone |
-
2011
- 2011-07-01 AU AU2011274361A patent/AU2011274361B2/en active Active
- 2011-07-01 WO PCT/US2011/042834 patent/WO2012003468A1/en not_active Ceased
- 2011-07-01 JP JP2013518764A patent/JP5988272B2/ja active Active
- 2011-07-01 PL PL11738337T patent/PL2588481T3/pl unknown
- 2011-07-01 ES ES11738337.2T patent/ES2659168T3/es active Active
- 2011-07-01 GB GB1301533.4A patent/GB2495062A/en not_active Withdrawn
- 2011-07-01 EP EP11738337.2A patent/EP2588481B1/en active Active
- 2011-07-01 US US13/175,537 patent/US8703950B2/en active Active
- 2011-07-01 CA CA2804101A patent/CA2804101C/en active Active
-
2014
- 2014-03-21 US US14/221,818 patent/US20140206871A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011274361B2 (en) | 2014-09-18 |
| JP2013531678A (ja) | 2013-08-08 |
| US20140206871A1 (en) | 2014-07-24 |
| EP2588481A1 (en) | 2013-05-08 |
| EP2588481B1 (en) | 2017-11-15 |
| WO2012003468A1 (en) | 2012-01-05 |
| AU2011274361A1 (en) | 2013-01-31 |
| CA2804101A1 (en) | 2012-01-05 |
| GB2495062A (en) | 2013-03-27 |
| US20120259118A1 (en) | 2012-10-11 |
| CA2804101C (en) | 2021-01-19 |
| JP5988272B2 (ja) | 2016-09-07 |
| ES2659168T3 (es) | 2018-03-14 |
| GB201301533D0 (en) | 2013-03-13 |
| US8703950B2 (en) | 2014-04-22 |
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