DE69829379D1 - Herstellung von oxymorphon, oxycodon und derivaten davon - Google Patents

Herstellung von oxymorphon, oxycodon und derivaten davon

Info

Publication number
DE69829379D1
DE69829379D1 DE69829379T DE69829379T DE69829379D1 DE 69829379 D1 DE69829379 D1 DE 69829379D1 DE 69829379 T DE69829379 T DE 69829379T DE 69829379 T DE69829379 T DE 69829379T DE 69829379 D1 DE69829379 D1 DE 69829379D1
Authority
DE
Germany
Prior art keywords
synthesis
oxymorphone
oxycodone
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69829379T
Other languages
German (de)
English (en)
Inventor
Bao-Shan Huang
Aris Christodoulou
Yansong Lu
Ben-Yi Ji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Penick Corp
Original Assignee
Penick Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25401603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69829379(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Penick Corp filed Critical Penick Corp
Application granted granted Critical
Publication of DE69829379D1 publication Critical patent/DE69829379D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69829379T 1997-07-11 1998-07-10 Herstellung von oxymorphon, oxycodon und derivaten davon Expired - Lifetime DE69829379D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/893,464 US5869669A (en) 1996-07-26 1997-07-11 Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
PCT/US1998/013592 WO1999002529A1 (en) 1997-07-11 1998-07-10 Preparation of oxymorphone, oxycodone and derivatives

Publications (1)

Publication Number Publication Date
DE69829379D1 true DE69829379D1 (de) 2005-04-21

Family

ID=25401603

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69829379T Expired - Lifetime DE69829379D1 (de) 1997-07-11 1998-07-10 Herstellung von oxymorphon, oxycodon und derivaten davon

Country Status (19)

Country Link
US (7) US5869669A (https=)
EP (1) EP1000065B1 (https=)
JP (1) JP2001518444A (https=)
KR (1) KR100363486B1 (https=)
CN (1) CN1152880C (https=)
AT (1) ATE291023T1 (https=)
AU (1) AU740822B2 (https=)
CA (1) CA2296035C (https=)
DE (1) DE69829379D1 (https=)
HU (1) HUP0003918A3 (https=)
IL (1) IL133792A0 (https=)
IN (1) IN1998KO01500A (https=)
NO (1) NO20000111L (https=)
RU (1) RU2183636C2 (https=)
SK (1) SK102000A3 (https=)
TR (1) TR200000033T2 (https=)
TW (1) TW505648B (https=)
WO (1) WO1999002529A1 (https=)
ZA (1) ZA986144B (https=)

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US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
RU2236412C2 (ru) * 2002-07-18 2004-09-20 Власов Михаил Иванович Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона
RU2215742C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
RU2215741C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
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EA012905B1 (ru) 2004-02-06 2010-02-26 Еуро-Селтик С.А. Способы получения 3-о-защищенных морфинов и 3-о-защищенных морфинондиенолкарбоксилатов
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Also Published As

Publication number Publication date
TR200000033T2 (tr) 2000-12-21
TW505648B (en) 2002-10-11
CN1272845A (zh) 2000-11-08
US6013796A (en) 2000-01-11
CN1152880C (zh) 2004-06-09
JP2001518444A (ja) 2001-10-16
HK1028025A1 (en) 2001-02-02
RU2183636C2 (ru) 2002-06-20
EP1000065B1 (en) 2005-03-16
CA2296035C (en) 2004-04-13
US5948788A (en) 1999-09-07
KR20010021693A (ko) 2001-03-15
ATE291023T1 (de) 2005-04-15
HUP0003918A2 (hu) 2001-07-30
CA2296035A1 (en) 1999-01-21
SK102000A3 (en) 2000-07-11
ZA986144B (en) 1999-05-19
EP1000065A1 (en) 2000-05-17
AU8379198A (en) 1999-02-08
AU740822B2 (en) 2001-11-15
KR100363486B1 (ko) 2002-12-16
IL133792A0 (en) 2001-04-30
NO20000111D0 (no) 2000-01-10
EP1000065A4 (en) 2001-09-12
NO20000111L (no) 2000-02-25
US5952495A (en) 1999-09-14
IN1998KO01500A (https=) 2005-03-11
US6008355A (en) 1999-12-28
HUP0003918A3 (en) 2003-04-28
US5922876A (en) 1999-07-13
WO1999002529A1 (en) 1999-01-21
US5869669A (en) 1999-02-09
US6008354A (en) 1999-12-28

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