IE46003L - Morphinans - Google Patents

Morphinans

Info

Publication number
IE46003L
IE46003L IE772468A IE246877A IE46003L IE 46003 L IE46003 L IE 46003L IE 772468 A IE772468 A IE 772468A IE 246877 A IE246877 A IE 246877A IE 46003 L IE46003 L IE 46003L
Authority
IE
Ireland
Prior art keywords
lower alkyl
integer
hydrogen
morphinans
ca1088935a
Prior art date
Application number
IE772468A
Other versions
IE46003B1 (en
Original Assignee
Hoffman La Roche And Co A G F
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/811,233 external-priority patent/US4113729A/en
Application filed by Hoffman La Roche And Co A G F filed Critical Hoffman La Roche And Co A G F
Publication of IE46003L publication Critical patent/IE46003L/en
Publication of IE46003B1 publication Critical patent/IE46003B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

Abstract

There are described levo-rotary 3-phenoxy morphinan derivatives of the general formula wherein R is halogen, nitro, lower alkyl, lower alkoxy, hydroxy or hydrogen; R1 is hydrogen, lower alkyl, lower alkenyl, -CH2(CH2)pR2 or -?-(CH2)p-R2; R2 is heteroaromatic, axomatic or cyclo-lower alkyl; p is an integer from 0 to 3; and n is an integer from 1 to 5 and pharmaceutically acceptable acid addition salts which are useful as analgesic and/or narcotic antagonists. [CA1088935A]
IE2468/77A 1976-12-06 1977-12-05 3-phenoxy-n-substituted morphinan derivatives, their manufacture and pharmaceutical preparations containing them IE46003B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74802276A 1976-12-06 1976-12-06
US05/811,233 US4113729A (en) 1976-12-06 1977-06-29 3-Phenoxymorphinans and derivatives thereof

Publications (2)

Publication Number Publication Date
IE46003L true IE46003L (en) 1978-06-06
IE46003B1 IE46003B1 (en) 1983-01-26

Family

ID=27114858

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2468/77A IE46003B1 (en) 1976-12-06 1977-12-05 3-phenoxy-n-substituted morphinan derivatives, their manufacture and pharmaceutical preparations containing them

Country Status (22)

Country Link
JP (1) JPS5392776A (en)
AR (1) AR219510A1 (en)
AT (1) AT364826B (en)
AU (1) AU514827B2 (en)
CA (1) CA1088935A (en)
DE (1) DE2754062A1 (en)
DK (1) DK540977A (en)
ES (3) ES464751A1 (en)
FI (1) FI773636A (en)
FR (1) FR2372808A1 (en)
GB (1) GB1589792A (en)
HU (1) HU177640B (en)
IE (1) IE46003B1 (en)
IL (1) IL53532A (en)
IT (1) IT1143727B (en)
LU (1) LU78638A1 (en)
MC (1) MC1172A1 (en)
NL (1) NL7713432A (en)
NO (1) NO774155L (en)
NZ (1) NZ185860A (en)
PT (1) PT67363B (en)
SE (1) SE7713779L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247697A (en) * 1979-09-10 1981-01-27 Hoffmann-La Roche Inc. 3-Phenoxy morphinans and their derivatives
TW264473B (en) * 1993-01-06 1995-12-01 Hoffmann La Roche

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH560194A5 (en) * 1967-08-25 1975-03-27 Hoffmann La Roche
JPS493961B1 (en) * 1969-06-24 1974-01-29

Also Published As

Publication number Publication date
AT364826B (en) 1981-11-25
LU78638A1 (en) 1979-02-02
ES472573A1 (en) 1979-02-16
SE7713779L (en) 1978-06-07
FR2372808B1 (en) 1981-07-10
ES472572A1 (en) 1979-02-16
IT1143727B (en) 1986-10-22
NL7713432A (en) 1978-06-08
DE2754062A1 (en) 1978-06-08
AU3126477A (en) 1979-06-14
HU177640B (en) 1981-11-28
PT67363A (en) 1978-01-01
GB1589792A (en) 1981-05-20
FI773636A (en) 1978-06-07
DK540977A (en) 1978-06-07
IL53532A0 (en) 1978-03-10
ES464751A1 (en) 1978-12-16
IL53532A (en) 1981-09-13
MC1172A1 (en) 1978-09-25
ATA869277A (en) 1981-04-15
JPS5392776A (en) 1978-08-15
FR2372808A1 (en) 1978-06-30
PT67363B (en) 1979-12-17
AR219510A1 (en) 1980-08-29
NO774155L (en) 1978-06-07
CA1088935A (en) 1980-11-04
IE46003B1 (en) 1983-01-26
AU514827B2 (en) 1981-02-26
NZ185860A (en) 1980-10-24

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