CN1151155C - 1,5-二氢-吡唑并[3,4-d]-嘧啶酮衍生物 - Google Patents

1,5-二氢-吡唑并[3,4-d]-嘧啶酮衍生物

Info

Publication number
CN1151155C
CN1151155C CNB988049872A CN98804987A CN1151155C CN 1151155 C CN1151155 C CN 1151155C CN B988049872 A CNB988049872 A CN B988049872A CN 98804987 A CN98804987 A CN 98804987A CN 1151155 C CN1151155 C CN 1151155C
Authority
CN
China
Prior art keywords
group
carbon atoms
phenyl
straight
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988049872A
Other languages
English (en)
Chinese (zh)
Other versions
CN1255133A (zh
Inventor
H
H·哈宁
U·尼沃纳
U·罗森特雷特
T·申克
ϣ
J·克尔德尼希
E·比肖夫
��Ĭ����
K·H·施莱默
H·许茨
G·托马斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of CN1255133A publication Critical patent/CN1255133A/zh
Application granted granted Critical
Publication of CN1151155C publication Critical patent/CN1151155C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB988049872A 1997-03-11 1998-02-26 1,5-二氢-吡唑并[3,4-d]-嘧啶酮衍生物 Expired - Fee Related CN1151155C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19709877A DE19709877A1 (de) 1997-03-11 1997-03-11 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
DE19709877.0 1997-03-11

Publications (2)

Publication Number Publication Date
CN1255133A CN1255133A (zh) 2000-05-31
CN1151155C true CN1151155C (zh) 2004-05-26

Family

ID=7822900

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988049872A Expired - Fee Related CN1151155C (zh) 1997-03-11 1998-02-26 1,5-二氢-吡唑并[3,4-d]-嘧啶酮衍生物

Country Status (17)

Country Link
US (1) US6174884B1 (https=)
EP (1) EP0973774B1 (https=)
JP (1) JP2001514638A (https=)
KR (1) KR20000076124A (https=)
CN (1) CN1151155C (https=)
AT (1) ATE231509T1 (https=)
AU (1) AU727615B2 (https=)
BR (1) BR9807995A (https=)
CA (1) CA2283211A1 (https=)
DE (2) DE19709877A1 (https=)
DK (1) DK0973774T3 (https=)
ES (1) ES2191294T3 (https=)
HU (1) HUP0001805A3 (https=)
IL (1) IL131450A0 (https=)
NZ (1) NZ337724A (https=)
RU (1) RU2219180C2 (https=)
WO (1) WO1998040384A1 (https=)

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GB9823103D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
EP1307201B1 (de) 2000-08-01 2004-11-24 Bayer HealthCare AG Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
EP1343506A1 (de) * 2000-12-19 2003-09-17 MERCK PATENT GmbH Pharmazeutische formulierung enthaltend pyrazolo 4,3-d]pyrimidine und antithrombotica, calcium-antagonisten, prostaglandine oder prostaglandinderivate
DE10064105A1 (de) 2000-12-21 2002-06-27 Bayer Ag Neue Substituierte Imidazotriazinone
JP2004525890A (ja) * 2001-02-02 2004-08-26 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング ピラゾロ［４，３−ｄ］ピリミジンおよびエンドセリンレセプターアンタゴニストまたはチエノピリミジンおよびエンドセリンレセプターアンタゴニストを含む医薬製剤
KR100393160B1 (ko) * 2001-06-14 2003-07-31 한국과학기술연구원 신규한 피라졸로피리미딘티온 유도체, 그의 제법 및발기부전 치료제로서의 용도
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
EP1436265A4 (en) * 2001-09-27 2004-12-15 Smithkline Beecham Corp CHEMICALS
FR2842809A1 (fr) * 2002-07-26 2004-01-30 Greenpharma Sas NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
DE10238723A1 (de) 2002-08-23 2004-03-11 Bayer Ag Phenyl-substituierte Pyrazolyprimidine
DE10238724A1 (de) 2002-08-23 2004-03-04 Bayer Ag Alkyl-substituierte Pyrazolpyrimidine
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
CN100397023C (zh) * 2003-01-04 2008-06-25 胡云北 黄磷废渣载热量及反应尾气发热量的回收与综合利用方法
HRP20050848A2 (en) * 2003-03-04 2006-06-30 Altana Pharma Ag Purin-6-one-derivatives
DE102004004142A1 (de) 2003-05-09 2004-11-25 Bayer Healthcare Ag 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine
DE10320785A1 (de) * 2003-05-09 2004-11-25 Bayer Healthcare Ag 6-Arylmethyl-substituierte Pyrazolopyrimidine
US8044060B2 (en) 2003-05-09 2011-10-25 Boehringer Ingelheim International Gmbh 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory
DE10328479A1 (de) 2003-06-25 2005-01-13 Bayer Ag 6-Arylamino-5-cyano-4-pyrimidinone
CA2536458A1 (en) * 2003-08-28 2005-03-10 Altana Pharma Ag Composition comprising a pulmonary surfactant and a pde2 inhibitor
DE102004001873A1 (de) 2004-01-14 2005-09-29 Bayer Healthcare Ag Cyanopyrimidinone
CN1934111A (zh) 2004-02-27 2007-03-21 霍夫曼-拉罗奇有限公司 杂芳基稠合的吡唑并衍生物
CN101397299B (zh) * 2007-09-29 2011-11-16 温州大学 一种吡唑[3,4-d]嘧啶酮的合成方法
JP5498392B2 (ja) 2007-11-30 2014-05-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｃｎｓ障害の治療のためのｐｄｅ９ａモジュレーターとしてのそれらの使用
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
KR20110063447A (ko) 2008-09-08 2011-06-10 베링거 인겔하임 인터내셔날 게엠베하 피라졸로피리미딘 및 ｃｎｓ 장애의 치료를 위한 이들의 용도
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JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
BR112015019276A2 (pt) 2013-02-19 2017-07-18 Pfizer compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios
JP6425717B2 (ja) 2013-10-04 2018-11-21 ファイザー・インク ガンマセクレターゼモジュレーターとしての新規二環式ピリジノン
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US3211732A (en) 1965-10-12 Pyrazolob:x-d]pyrlil/hdines
US3165520A (en) * 1965-01-12 Certificate of correction
CH398626A (de) * 1960-05-11 1966-03-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazolopyrimidine
DE1153023B (de) 1960-05-11 1963-08-22 Ciba Geigy Verfahren zur Herstellung von 4-Hydroxy-pyrazolo[3,4-d] pyrimidinen
CH633297A5 (de) 1977-09-16 1982-11-30 Sandoz Ag Verfahren zur herstellung von fluorenphosphoniten.
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PL322452A1 (en) * 1995-03-10 1998-02-02 Sanofi Pharmaceuticals 6-arylpyrasole [3,4-d]pyrimidin-4-ones, preparations containing such compounds and methods of mking use of them
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Also Published As

Publication number Publication date
IL131450A0 (en) 2001-01-28
NZ337724A (en) 2000-08-25
HK1028035A1 (en) 2001-02-02
AU727615B2 (en) 2000-12-14
KR20000076124A (ko) 2000-12-26
CN1255133A (zh) 2000-05-31
AU6824098A (en) 1998-09-29
RU2219180C2 (ru) 2003-12-20
ATE231509T1 (de) 2003-02-15
DE19709877A1 (de) 1998-09-17
US6174884B1 (en) 2001-01-16
HUP0001805A2 (hu) 2000-11-28
HUP0001805A3 (en) 2002-09-30
JP2001514638A (ja) 2001-09-11
EP0973774A1 (de) 2000-01-26
BR9807995A (pt) 2000-03-08
ES2191294T3 (es) 2003-09-01
CA2283211A1 (en) 1998-09-17
EP0973774B1 (de) 2003-01-22
WO1998040384A1 (de) 1998-09-17
DE59807011D1 (de) 2003-02-27
DK0973774T3 (da) 2003-05-05

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