CA2283211A1 - 1,5-dihydro-pyrazolo[3,4-d]-pyrimidinone derivatives - Google Patents

1,5-dihydro-pyrazolo[3,4-d]-pyrimidinone derivatives Download PDF

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Publication number
CA2283211A1
CA2283211A1 CA002283211A CA2283211A CA2283211A1 CA 2283211 A1 CA2283211 A1 CA 2283211A1 CA 002283211 A CA002283211 A CA 002283211A CA 2283211 A CA2283211 A CA 2283211A CA 2283211 A1 CA2283211 A1 CA 2283211A1
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CA
Canada
Prior art keywords
chain
carbon atoms
straight
formula
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002283211A
Other languages
English (en)
French (fr)
Inventor
Helmut Haning
Ulrich Niewohner
Ulrich Rosentreter
Thomas Schenke
Jorg Keldenich
Erwin Bischoff
Karl-Heinz Schlemmer
Helmuth Schutz
Gunter Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2283211A1 publication Critical patent/CA2283211A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002283211A 1997-03-11 1998-02-26 1,5-dihydro-pyrazolo[3,4-d]-pyrimidinone derivatives Abandoned CA2283211A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19709877A DE19709877A1 (de) 1997-03-11 1997-03-11 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
DE19709877.0 1997-03-11
PCT/EP1998/001086 WO1998040384A1 (de) 1997-03-11 1998-02-26 1,5-dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate

Publications (1)

Publication Number Publication Date
CA2283211A1 true CA2283211A1 (en) 1998-09-17

Family

ID=7822900

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002283211A Abandoned CA2283211A1 (en) 1997-03-11 1998-02-26 1,5-dihydro-pyrazolo[3,4-d]-pyrimidinone derivatives

Country Status (17)

Country Link
US (1) US6174884B1 (https=)
EP (1) EP0973774B1 (https=)
JP (1) JP2001514638A (https=)
KR (1) KR20000076124A (https=)
CN (1) CN1151155C (https=)
AT (1) ATE231509T1 (https=)
AU (1) AU727615B2 (https=)
BR (1) BR9807995A (https=)
CA (1) CA2283211A1 (https=)
DE (2) DE19709877A1 (https=)
DK (1) DK0973774T3 (https=)
ES (1) ES2191294T3 (https=)
HU (1) HUP0001805A3 (https=)
IL (1) IL131450A0 (https=)
NZ (1) NZ337724A (https=)
RU (1) RU2219180C2 (https=)
WO (1) WO1998040384A1 (https=)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7488733B2 (en) 2003-06-25 2009-02-10 Boehringer Ingelheim International Gmbh 6-arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors
US7615558B2 (en) 2003-05-09 2009-11-10 Boehringer Ingelheim International Gmbh 6-arylmethylprazolo[3,4-d]pyrimidines
US7737156B2 (en) 2002-08-23 2010-06-15 Boehringer Ingelheim International Gmbh Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes
US8039477B2 (en) 2002-08-23 2011-10-18 Boehringer Ingelheim International Gmbh Substituted pyrazolo[3,4-d]pyrimidin-4-one compounds as phosphodiesterase inhibitors
US8044060B2 (en) 2003-05-09 2011-10-25 Boehringer Ingelheim International Gmbh 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory
US8088769B2 (en) 2004-01-14 2012-01-03 Boehringer Ingelheim International Gmbh Cyanopyrimidinones
US8158633B2 (en) 2002-08-23 2012-04-17 Boehringer Ingelheim International Gmbh Phenyl-substituted pyrazolopyrimidines
US8623901B2 (en) 2009-03-31 2014-01-07 Boehringer Ingelheim International Gmbh Compounds for the treatment of CNS disorders
US8623879B2 (en) 2008-04-02 2014-01-07 Boehringer Ingelheim International Gmbh 1-heterocyclyl-1,5-dihydro-pyrazolo[3,4-D] pyrimidin-4-one derivates and their use as PDE9A modulators
US8648085B2 (en) 2007-11-30 2014-02-11 Boehringer Ingelheim International Gmbh 1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
US8912201B2 (en) 2010-08-12 2014-12-16 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
US9079905B2 (en) 2008-09-08 2015-07-14 Boehringer Ingelheim International Gmbh Compounds for the treatment of CNS disorders

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GB9823103D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
EP1307201B1 (de) 2000-08-01 2004-11-24 Bayer HealthCare AG Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
EP1343506A1 (de) * 2000-12-19 2003-09-17 MERCK PATENT GmbH Pharmazeutische formulierung enthaltend pyrazolo 4,3-d]pyrimidine und antithrombotica, calcium-antagonisten, prostaglandine oder prostaglandinderivate
DE10064105A1 (de) 2000-12-21 2002-06-27 Bayer Ag Neue Substituierte Imidazotriazinone
JP2004525890A (ja) * 2001-02-02 2004-08-26 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング ピラゾロ［４，３−ｄ］ピリミジンおよびエンドセリンレセプターアンタゴニストまたはチエノピリミジンおよびエンドセリンレセプターアンタゴニストを含む医薬製剤
KR100393160B1 (ko) * 2001-06-14 2003-07-31 한국과학기술연구원 신규한 피라졸로피리미딘티온 유도체, 그의 제법 및발기부전 치료제로서의 용도
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
EP1436265A4 (en) * 2001-09-27 2004-12-15 Smithkline Beecham Corp CHEMICALS
FR2842809A1 (fr) * 2002-07-26 2004-01-30 Greenpharma Sas NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
CN100397023C (zh) * 2003-01-04 2008-06-25 胡云北 黄磷废渣载热量及反应尾气发热量的回收与综合利用方法
HRP20050848A2 (en) * 2003-03-04 2006-06-30 Altana Pharma Ag Purin-6-one-derivatives
DE102004004142A1 (de) 2003-05-09 2004-11-25 Bayer Healthcare Ag 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine
CA2536458A1 (en) * 2003-08-28 2005-03-10 Altana Pharma Ag Composition comprising a pulmonary surfactant and a pde2 inhibitor
CN1934111A (zh) 2004-02-27 2007-03-21 霍夫曼-拉罗奇有限公司 杂芳基稠合的吡唑并衍生物
CN101397299B (zh) * 2007-09-29 2011-11-16 温州大学 一种吡唑[3,4-d]嘧啶酮的合成方法
AU2010232729A1 (en) 2009-03-31 2011-10-20 Arqule, Inc. Substituted indolo-pyridinone compounds
TW201118099A (en) * 2009-08-12 2011-06-01 Boehringer Ingelheim Int New compounds for the treatment of CNS disorders
US20130040971A1 (en) 2011-02-14 2013-02-14 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of cns disorders
CA2830027C (en) 2011-03-31 2016-04-26 Pfizer Inc. Novel bicyclic pyridinones
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
JP6043355B2 (ja) 2011-08-31 2016-12-14 ファイザー・インク ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
BR112015019276A2 (pt) 2013-02-19 2017-07-18 Pfizer compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios
JP6425717B2 (ja) 2013-10-04 2018-11-21 ファイザー・インク ガンマセクレターゼモジュレーターとしての新規二環式ピリジノン
AP2016009465A0 (en) 2014-04-01 2016-09-30 Pfizer Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators
WO2016012896A1 (en) 2014-07-24 2016-01-28 Pfizer Inc. Pyrazolopyrimidine compounds
MD20170011A2 (ro) 2014-08-06 2017-08-31 Pfizer Inc. Compuşi imidazopiridazinici
MX368391B (es) 2015-02-03 2019-09-30 Pfizer Ciclopropabenzofuranil-piridopirazindionas novedosas.
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
WO2016179059A1 (en) * 2015-05-05 2016-11-10 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as pde2 inhibitors
CN107787322B (zh) 2015-06-17 2023-07-07 辉瑞大药厂 三环化合物以及它们作为磷酸二酯酶抑制剂的用途
CN113332292A (zh) 2016-02-23 2021-09-03 辉瑞公司 6,7-二氢-5H-吡唑并[5,1-b][1,3]噁嗪-2-甲酰胺化合物
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
PT3478679T (pt) 2016-07-01 2021-06-30 Pfizer Derivados de 5,7-dihidro-pirrolo-piridina para o tratamento de doenças neurológicas e neurodegenerativas
WO2018073251A1 (en) * 2016-10-18 2018-04-26 H. Lundbeck A/S Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as pde1 inhibitors
AU2017350473A1 (en) 2016-10-28 2019-04-18 H. Lundbeck A/S Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders
WO2018078042A1 (en) 2016-10-28 2018-05-03 H. Lundbeck A/S Combination treatments comprising administration of imidazopyrazinones
KR102590848B1 (ko) 2016-12-28 2023-10-19 다트 뉴로사이언스, 엘엘씨 Pde2 억제제로서 치환된 피라졸로피리미디논 화합물
AU2018281131B2 (en) 2017-06-08 2022-01-20 Merck Sharp & Dohme Corp. Pyrazolopyrimidine PDE9 inhibitors
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DK3717488T3 (da) 2017-11-27 2021-12-13 Dart Neuroscience Llc Substituerede furanopyrimidinforbindelser som pde1-inhibitorer
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CH633297A5 (de) 1977-09-16 1982-11-30 Sandoz Ag Verfahren zur herstellung von fluorenphosphoniten.
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PL322452A1 (en) * 1995-03-10 1998-02-02 Sanofi Pharmaceuticals 6-arylpyrasole [3,4-d]pyrimidin-4-ones, preparations containing such compounds and methods of mking use of them
US5656629A (en) 1995-03-10 1997-08-12 Sanofi Winthrop, Inc. 6-substituted pyrazolo (3,4-d)pyrimidin-4-ones and compositions and methods of use thereof

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8741907B2 (en) 2002-08-23 2014-06-03 Boehringer Ingelheim International Gmbh Alkyl-substituted pyrazolopyrimidines
US7737156B2 (en) 2002-08-23 2010-06-15 Boehringer Ingelheim International Gmbh Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes
US8039477B2 (en) 2002-08-23 2011-10-18 Boehringer Ingelheim International Gmbh Substituted pyrazolo[3,4-d]pyrimidin-4-one compounds as phosphodiesterase inhibitors
US8158633B2 (en) 2002-08-23 2012-04-17 Boehringer Ingelheim International Gmbh Phenyl-substituted pyrazolopyrimidines
US9067945B2 (en) 2002-08-23 2015-06-30 Boehringer Ingehleim International GmbH Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes
US8455502B2 (en) 2002-08-23 2013-06-04 Boehringer Ingelheim International Gmbh Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes
US7615558B2 (en) 2003-05-09 2009-11-10 Boehringer Ingelheim International Gmbh 6-arylmethylprazolo[3,4-d]pyrimidines
US8044060B2 (en) 2003-05-09 2011-10-25 Boehringer Ingelheim International Gmbh 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory
US8822479B2 (en) 2003-05-09 2014-09-02 Boehringer Ingelheim International Gmbh 6-cyclylmethyl-and 6-alkylmethyl-substituted pyrazolepyrimidines
US8809348B2 (en) 2003-05-09 2014-08-19 Boehringer Ingelheim International Gmbh 6-arylmethyl substituted pyrazolo[3,4-d]pyrimidines
US8642605B2 (en) 2003-05-09 2014-02-04 Boehringer Ingelheim International Gmbh 6-cyclylmethyl-and 6-alkylmethyl-substituted pyrazolepyrimidines
US7488733B2 (en) 2003-06-25 2009-02-10 Boehringer Ingelheim International Gmbh 6-arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors
US8088769B2 (en) 2004-01-14 2012-01-03 Boehringer Ingelheim International Gmbh Cyanopyrimidinones
US8431573B2 (en) 2004-01-14 2013-04-30 Boehringer Ingelheim International Gmbh Cyanopyrimidinones
US8648085B2 (en) 2007-11-30 2014-02-11 Boehringer Ingelheim International Gmbh 1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders
US8623879B2 (en) 2008-04-02 2014-01-07 Boehringer Ingelheim International Gmbh 1-heterocyclyl-1,5-dihydro-pyrazolo[3,4-D] pyrimidin-4-one derivates and their use as PDE9A modulators
US9096603B2 (en) 2008-04-02 2015-08-04 Boehringer Ingelheim International Gmbh 1-heterocyclyl-1,5-dihydro-pyrazolo[3,4-D] pyrimidin-4-one derivatives and their use as PDE9A modulators
US9079905B2 (en) 2008-09-08 2015-07-14 Boehringer Ingelheim International Gmbh Compounds for the treatment of CNS disorders
US8623901B2 (en) 2009-03-31 2014-01-07 Boehringer Ingelheim International Gmbh Compounds for the treatment of CNS disorders
US9102679B2 (en) 2009-03-31 2015-08-11 Boehringer Ingelheim International Gmbh Compounds for the treatment of CNS disorders
US8912201B2 (en) 2010-08-12 2014-12-16 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
US9328120B2 (en) 2010-08-12 2016-05-03 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders

Also Published As

Publication number Publication date
IL131450A0 (en) 2001-01-28
CN1151155C (zh) 2004-05-26
NZ337724A (en) 2000-08-25
HK1028035A1 (en) 2001-02-02
AU727615B2 (en) 2000-12-14
KR20000076124A (ko) 2000-12-26
CN1255133A (zh) 2000-05-31
AU6824098A (en) 1998-09-29
RU2219180C2 (ru) 2003-12-20
ATE231509T1 (de) 2003-02-15
DE19709877A1 (de) 1998-09-17
US6174884B1 (en) 2001-01-16
HUP0001805A2 (hu) 2000-11-28
HUP0001805A3 (en) 2002-09-30
JP2001514638A (ja) 2001-09-11
EP0973774A1 (de) 2000-01-26
BR9807995A (pt) 2000-03-08
ES2191294T3 (es) 2003-09-01
EP0973774B1 (de) 2003-01-22
WO1998040384A1 (de) 1998-09-17
DE59807011D1 (de) 2003-02-27
DK0973774T3 (da) 2003-05-05

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