CN115054586B - 改性的释放制剂 - Google Patents

改性的释放制剂 Download PDF

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Publication number
CN115054586B
CN115054586B CN202210686970.6A CN202210686970A CN115054586B CN 115054586 B CN115054586 B CN 115054586B CN 202210686970 A CN202210686970 A CN 202210686970A CN 115054586 B CN115054586 B CN 115054586B
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dosage form
oral dosage
modified release
solid oral
compound
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CN115054586A (zh
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A·J·费尔多斯
M·R·马斯杰迪扎德
W·林
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Principia Biopharma Inc
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Principia Biopharma Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
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  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nutrition Science (AREA)
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CN202210686970.6A 2016-06-29 2017-06-29 改性的释放制剂 Active CN115054586B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210686970.6A CN115054586B (zh) 2016-06-29 2017-06-29 改性的释放制剂

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662356345P 2016-06-29 2016-06-29
US62/356,345 2016-06-29
CN202210686970.6A CN115054586B (zh) 2016-06-29 2017-06-29 改性的释放制剂
PCT/US2017/040075 WO2018005849A1 (en) 2016-06-29 2017-06-29 Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
CN201780049475.1A CN109600989B (zh) 2016-06-29 2017-06-29 2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁烷-3-基)哌嗪-1-基]戊-2-烯腈的改性的释放制剂

Related Parent Applications (1)

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CN201780049475.1A Division CN109600989B (zh) 2016-06-29 2017-06-29 2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁烷-3-基)哌嗪-1-基]戊-2-烯腈的改性的释放制剂

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CN115054586A CN115054586A (zh) 2022-09-16
CN115054586B true CN115054586B (zh) 2024-08-02

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CN202210686970.6A Active CN115054586B (zh) 2016-06-29 2017-06-29 改性的释放制剂
CN201780049475.1A Active CN109600989B (zh) 2016-06-29 2017-06-29 2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁烷-3-基)哌嗪-1-基]戊-2-烯腈的改性的释放制剂

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CN201780049475.1A Active CN109600989B (zh) 2016-06-29 2017-06-29 2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁烷-3-基)哌嗪-1-基]戊-2-烯腈的改性的释放制剂

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US (4) US20190231784A1 (https=)
EP (1) EP3478273A1 (https=)
JP (1) JP7129704B2 (https=)
KR (2) KR102391693B1 (https=)
CN (2) CN115054586B (https=)
AU (2) AU2017290354C1 (https=)
CA (1) CA3028169C (https=)
EA (1) EA201892836A1 (https=)
IL (2) IL263815B (https=)
MA (1) MA45547A (https=)
MX (2) MX390619B (https=)
SG (1) SG11201811255WA (https=)
WO (1) WO2018005849A1 (https=)

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CN112353806A (zh) 2014-02-21 2021-02-12 普林斯匹亚生物制药公司 Btk抑制剂的盐和固体形式
SG11201704808VA (en) 2014-12-18 2017-07-28 Principia Biopharma Inc Treatment of pemphigus
WO2016210165A1 (en) 2015-06-24 2016-12-29 Principia Biopharma Inc. Tyrosine kinase inhibitors
CN115054586B (zh) 2016-06-29 2024-08-02 普林斯匹亚生物制药公司 改性的释放制剂
KR20210038877A (ko) 2018-07-25 2021-04-08 노파르티스 아게 Nlrp3 인플라마좀 억제제
WO2020119785A1 (zh) 2018-12-14 2020-06-18 正大天晴药业集团股份有限公司 一种Syk抑制剂的盐及其结晶型
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
KR20220079909A (ko) 2019-10-09 2022-06-14 프린시피아 바이오파마, 인코퍼레이티드 (R)-2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴을 투여하여 천포창을 치료하는 방법
US20210106584A1 (en) 2019-10-14 2021-04-15 Principia Biopharma Inc. Methods for treating immune thrombocytopenia by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
BR112022011950A2 (pt) * 2020-01-06 2022-09-06 Principia Biopharma Inc Tratamento da nefropatia membranosa, doença relacionada ao igg4, e síndrome antifosfolipídica usando o inibidor btk 2-[(3r)-3-[4-4-amino-3-(2-fluoro-4-4-fenoxi-fenil)pirazolo[3], 4-4-d]pyrimidin-1-yl]piperidina-1-carbonil]-4-4-metil-4-4-[4-4-(oxetan-3-yl)piperazin-1-il]pent-2-enenitrila
AU2021205248A1 (en) * 2020-01-08 2022-09-01 Principia Biopharma Inc. Topical pharmaceutical compositions comprising 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4,4-dimethylpent-2-enenitrile
US11814390B2 (en) 2020-01-22 2023-11-14 Principia Biopharma Inc. Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
WO2022033460A1 (zh) * 2020-08-10 2022-02-17 江苏恒瑞医药股份有限公司 Btk抑制剂治疗疾病的用途
JP7545570B2 (ja) 2020-08-14 2024-09-04 ノバルティス アーゲー ヘテロアリール置換スピロピペリジニル誘導体及びその薬学的使用
EP4322957A1 (en) 2021-04-16 2024-02-21 Principia Biopharma Inc. Methods for treating drug and vaccine induced immune thrombocytopenia by administering specific compounds
US20260000620A1 (en) * 2022-01-13 2026-01-01 Amryt Endo, Inc. Oral dosage forms
UY40374A (es) 2022-08-03 2024-02-15 Novartis Ag Inhibidores de inflamasoma nlrp3
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