JP7129704B2 - ２－［３－［４－アミノ－３－（２－フルオロ－４－フェノキシ－フェニル）ピラゾロ［３，４－ｄ］ピリミジン－１－イル］ピペリジン－１－カルボニル］－４－メチル－４－［４－（オキセタン－３－イル）ピペラジン－１－イル］ペント－２－エネニトリルの放出調節製剤 - Google Patents

２－［３－［４－アミノ－３－（２－フルオロ－４－フェノキシ－フェニル）ピラゾロ［３，４－ｄ］ピリミジン－１－イル］ピペリジン－１－カルボニル］－４－メチル－４－［４－（オキセタン－３－イル）ピペラジン－１－イル］ペント－２－エネニトリルの放出調節製剤 Download PDF

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JP7129704B2
JP7129704B2 JP2018568426A JP2018568426A JP7129704B2 JP 7129704 B2 JP7129704 B2 JP 7129704B2 JP 2018568426 A JP2018568426 A JP 2018568426A JP 2018568426 A JP2018568426 A JP 2018568426A JP 7129704 B2 JP7129704 B2 JP 7129704B2
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solid oral
modified release
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compound
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ジェイ． フェルドース，アブ
アール． マゼジザデー，モハマド
リン，ウー
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プリンシピア バイオファーマ インコーポレイテッド
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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JP2018568426A 2016-06-29 2017-06-29 ２－［３－［４－アミノ－３－（２－フルオロ－４－フェノキシ－フェニル）ピラゾロ［３，４－ｄ］ピリミジン－１－イル］ピペリジン－１－カルボニル］－４－メチル－４－［４－（オキセタン－３－イル）ピペラジン－１－イル］ペント－２－エネニトリルの放出調節製剤 Active JP7129704B2 (ja)

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US201662356345P 2016-06-29 2016-06-29
US62/356,345 2016-06-29
PCT/US2017/040075 WO2018005849A1 (en) 2016-06-29 2017-06-29 Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

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JP2019519581A JP2019519581A (ja) 2019-07-11
JP2019519581A5 JP2019519581A5 (https=) 2020-08-13
JP7129704B2 true JP7129704B2 (ja) 2022-09-02

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US (4) US20190231784A1 (https=)
EP (1) EP3478273A1 (https=)
JP (1) JP7129704B2 (https=)
KR (2) KR102391693B1 (https=)
CN (2) CN109600989B (https=)
AU (2) AU2017290354C1 (https=)
CA (1) CA3028169C (https=)
EA (1) EA201892836A1 (https=)
IL (2) IL293621B2 (https=)
MA (1) MA45547A (https=)
MX (2) MX390619B (https=)
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US20210106583A1 (en) 2019-10-09 2021-04-15 Principia Biopharma Inc. Methods of treating pemphigus by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
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TW202142237A (zh) * 2020-01-08 2021-11-16 美商普林斯匹亞生物製藥公司 包含2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)-1h-吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4,4-二甲基戊-2-烯腈之局部醫藥組成物
JP2023511105A (ja) 2020-01-22 2023-03-16 プリンシピア バイオファーマ インコーポレイテッド ２－［３－［４－アミノ－３－（２－フルオロ－４－フェノキシ－フェニル）－１ｈ－ピラゾロ［３，４－ｄ］ピリミジン－１－イル］ピペリジン－１－カルボニル］－４－メチル－４－［４－（オキセタン－３－イル）ピペラジン－１－イル］ペンタ－２－エンニトリルの結晶形態
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JP2016503063A (ja) 2012-12-20 2016-02-01 ザ ペン ステイト リサーチ ファンデーション がんの治療に関する方法及び組成物
WO2014171542A1 (ja) 2013-04-19 2014-10-23 武田薬品工業株式会社 放出制御製剤
WO2015127310A1 (en) 2014-02-21 2015-08-27 Principia Biopharma Inc. Salts and solid form of a btk inhibitor

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