CN114901701A - 一种超低分子量透明质酸及其制备方法 - Google Patents
一种超低分子量透明质酸及其制备方法 Download PDFInfo
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- CN114901701A CN114901701A CN202080090006.6A CN202080090006A CN114901701A CN 114901701 A CN114901701 A CN 114901701A CN 202080090006 A CN202080090006 A CN 202080090006A CN 114901701 A CN114901701 A CN 114901701A
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- hyaluronic acid
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Abstract
本发明公开了一种超低分子量透明质酸及其制备方法，属于生物化工技术领域。本发明利用大分子透明质酸为原料，经过透明质酸酶水解、加热灭活、活性炭过滤及喷雾干燥等生产工艺，可得到平均分子量低于1200道尔顿的超低分子量透明质酸产物。其为透明质酸二糖至十二糖的混合物，透明质酸二糖含量占比为5‑40％，透明质酸四糖含量占比40‑70％，透明质酸六糖含量占比10‑30％，透明质酸八糖含量占比1‑15％，透明质酸十糖含量占比1‑10％，透明质酸十糖以上含量占比低于6％，与普通市售的低分子透明质酸相比，该产品拥有更显著的渗透补水与促进修复能力，可广泛用于医药产品、保健产品、化妆品等领域。该方法操作简便、条件温和、未使用有机溶剂、酶解效率高，适宜大规模工业化生产。
Description
PCT国内申请，说明书已公开。
Claims (11)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911331251.7A CN111040048A (zh) | 2019-12-21 | 2019-12-21 | 一种超低分子量透明质酸及其制备方法 |
| CN2019113312517 | 2019-12-21 | ||
| PCT/CN2020/091956 WO2021120521A1 (zh) | 2019-12-21 | 2020-05-23 | 一种超低分子量透明质酸及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114901701A true CN114901701A (zh) | 2022-08-12 |
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| CN201911331251.7A Pending CN111040048A (zh) | 2019-12-21 | 2019-12-21 | 一种超低分子量透明质酸及其制备方法 |
| CN202080090006.6A Pending CN114901701A (zh) | 2019-12-21 | 2020-05-23 | 一种超低分子量透明质酸及其制备方法 |
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| CN201911331251.7A Pending CN111040048A (zh) | 2019-12-21 | 2019-12-21 | 一种超低分子量透明质酸及其制备方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20220380488A1 (zh) |
| CN (2) | CN111040048A (zh) |
| WO (1) | WO2021120521A1 (zh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111040048A (zh) * | 2019-12-21 | 2020-04-21 | 南京汉欣医药科技有限公司 | 一种超低分子量透明质酸及其制备方法 |
| CN111893151A (zh) * | 2020-08-21 | 2020-11-06 | 浙江绿创生物科技股份有限公司 | 一种连续化生产低分子量透明质酸的方法及所得低分子量透明质酸和应用 |
| CN115029402A (zh) * | 2021-03-05 | 2022-09-09 | 湖州蔻婷生物科技有限公司 | 一种寡聚透明质酸及其水解胶原蛋白和纤连蛋白复配化妆品组合物 |
| CN113150187B (zh) * | 2021-05-28 | 2022-03-25 | 杨彦威 | 一种超低分子量质酸钙与脲的络合物及其制备方法与应用 |
| CN113493776B (zh) * | 2021-07-07 | 2022-06-14 | 山东焦点福瑞达生物股份有限公司 | 一种连续制备酶切超低分子量透明质酸或其盐的方法 |
| CN113876623A (zh) * | 2021-09-24 | 2022-01-04 | 华熙生物科技股份有限公司 | 一种透明质酸寡糖组合物在抗皮肤衰老、促进胶原蛋白生成中的用途 |
| CN113801904A (zh) * | 2021-09-17 | 2021-12-17 | 山东华熙海御生物医药有限公司 | 一种透明质酸寡糖组合物及其制备方法和用途 |
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