CN112955139B - 用于制备α-酮戊二酸钙的方法 - Google Patents

用于制备α-酮戊二酸钙的方法 Download PDF

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Publication number
CN112955139B
CN112955139B CN201980073655.2A CN201980073655A CN112955139B CN 112955139 B CN112955139 B CN 112955139B CN 201980073655 A CN201980073655 A CN 201980073655A CN 112955139 B CN112955139 B CN 112955139B
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ketoglutarate
water
ketoglutaric acid
calcium
alpha
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CN112955139A (zh
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D·E·佩雷拉
K·迪欧
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Poncci Leon Health Specific Events
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/418—Preparation of metal complexes containing carboxylic acid moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201980073655.2A 2018-09-25 2019-09-23 用于制备α-酮戊二酸钙的方法 Active CN112955139B (zh)

Applications Claiming Priority (3)

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US201862736320P 2018-09-25 2018-09-25
US62/736,320 2018-09-25
PCT/US2019/052498 WO2020068705A1 (en) 2018-09-25 2019-09-23 Process of making calcium alpha-ketoglutarate

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CN112955139A CN112955139A (zh) 2021-06-11
CN112955139B true CN112955139B (zh) 2025-04-18

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EP (1) EP3856166A4 (https=)
JP (1) JP7499259B2 (https=)
KR (1) KR102833111B1 (https=)
CN (1) CN112955139B (https=)
AU (1) AU2019350699B2 (https=)
BR (1) BR112021005668A2 (https=)
CA (1) CA3112205A1 (https=)
CL (1) CL2021000728A1 (https=)
CO (1) CO2021004529A2 (https=)
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PE (1) PE20211816A1 (https=)
PH (1) PH12021550403A1 (https=)
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Families Citing this family (5)

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JP7499259B2 (ja) 2018-09-25 2024-06-13 ポンス デ レオン ヘルス デジグネイテッド アクティビティ カンパニー αケトグルタル酸カルシウムを製造するためのプロセス
CN112941116B (zh) * 2021-01-04 2022-12-02 上海朴颐化学科技有限公司 一种酶法制备α-酮戊二酸钙的方法
CN114105761B (zh) * 2021-11-19 2024-06-21 广东派特埃尔生物科技有限公司 一种α-酮戊二酸钠盐的合成工艺
CN115974679A (zh) * 2022-12-20 2023-04-18 绍兴市精益生物化工有限公司 α-酮戊二酸钙盐制备方法
CN119977789A (zh) * 2025-02-12 2025-05-13 江苏惠利生物科技有限公司 一种离子交换树脂制备高纯度α-酮戊二酸钙的方法

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CN112941116A (zh) * 2021-01-04 2021-06-11 上海朴颐化学科技有限公司 一种酶法制备α-酮戊二酸钙的方法
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CN115974679A (zh) * 2022-12-20 2023-04-18 绍兴市精益生物化工有限公司 α-酮戊二酸钙盐制备方法

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US11802103B2 (en) 2023-10-31
US20210371368A1 (en) 2021-12-02
KR102833111B1 (ko) 2025-07-10
JP7499259B2 (ja) 2024-06-13
IL281761B1 (en) 2025-05-01
PE20211816A1 (es) 2021-09-14
CO2021004529A2 (es) 2021-04-30
TWI863930B (zh) 2024-12-01
SG11202102204PA (en) 2021-04-29
WO2020068705A1 (en) 2020-04-02
JP2022502489A (ja) 2022-01-11
EP3856166A1 (en) 2021-08-04
KR20210065120A (ko) 2021-06-03
EP3856166A4 (en) 2022-06-22
MY203278A (en) 2024-06-21
PH12021550403A1 (en) 2021-10-04
CL2021000728A1 (es) 2021-10-22
BR112021005668A2 (pt) 2021-06-22
MX2021003482A (es) 2021-06-18
TW202024013A (zh) 2020-07-01
IL281761A (en) 2021-05-31
AU2019350699B2 (en) 2024-05-23
AU2019350699A1 (en) 2021-04-08
IL281761B2 (en) 2025-09-01
CN112955139A (zh) 2021-06-11
CA3112205A1 (en) 2020-04-02

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