IL281761B2 - Process for preparing calcium alpha-ketoglutarate - Google Patents

Process for preparing calcium alpha-ketoglutarate

Info

Publication number
IL281761B2
IL281761B2 IL281761A IL28176121A IL281761B2 IL 281761 B2 IL281761 B2 IL 281761B2 IL 281761 A IL281761 A IL 281761A IL 28176121 A IL28176121 A IL 28176121A IL 281761 B2 IL281761 B2 IL 281761B2
Authority
IL
Israel
Prior art keywords
alpha
ketoglutaric acid
water
ketoglutarate
weight
Prior art date
Application number
IL281761A
Other languages
English (en)
Hebrew (he)
Other versions
IL281761B1 (en
IL281761A (en
Original Assignee
Ponce De Leon Health Designated Activity Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ponce De Leon Health Designated Activity Company filed Critical Ponce De Leon Health Designated Activity Company
Publication of IL281761A publication Critical patent/IL281761A/en
Publication of IL281761B1 publication Critical patent/IL281761B1/en
Publication of IL281761B2 publication Critical patent/IL281761B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/418—Preparation of metal complexes containing carboxylic acid moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL281761A 2018-09-25 2019-09-23 Process for preparing calcium alpha-ketoglutarate IL281761B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862736320P 2018-09-25 2018-09-25
PCT/US2019/052498 WO2020068705A1 (en) 2018-09-25 2019-09-23 Process of making calcium alpha-ketoglutarate

Publications (3)

Publication Number Publication Date
IL281761A IL281761A (en) 2021-05-31
IL281761B1 IL281761B1 (en) 2025-05-01
IL281761B2 true IL281761B2 (en) 2025-09-01

Family

ID=69952136

Family Applications (1)

Application Number Title Priority Date Filing Date
IL281761A IL281761B2 (en) 2018-09-25 2019-09-23 Process for preparing calcium alpha-ketoglutarate

Country Status (18)

Country Link
US (1) US11802103B2 (https=)
EP (1) EP3856166A4 (https=)
JP (1) JP7499259B2 (https=)
KR (1) KR102833111B1 (https=)
CN (1) CN112955139B (https=)
AU (1) AU2019350699B2 (https=)
BR (1) BR112021005668A2 (https=)
CA (1) CA3112205A1 (https=)
CL (1) CL2021000728A1 (https=)
CO (1) CO2021004529A2 (https=)
IL (1) IL281761B2 (https=)
MX (1) MX2021003482A (https=)
MY (1) MY203278A (https=)
PE (1) PE20211816A1 (https=)
PH (1) PH12021550403A1 (https=)
SG (1) SG11202102204PA (https=)
TW (1) TWI863930B (https=)
WO (1) WO2020068705A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7499259B2 (ja) 2018-09-25 2024-06-13 ポンス デ レオン ヘルス デジグネイテッド アクティビティ カンパニー αケトグルタル酸カルシウムを製造するためのプロセス
CN112941116B (zh) * 2021-01-04 2022-12-02 上海朴颐化学科技有限公司 一种酶法制备α-酮戊二酸钙的方法
CN114105761B (zh) * 2021-11-19 2024-06-21 广东派特埃尔生物科技有限公司 一种α-酮戊二酸钠盐的合成工艺
CN115974679A (zh) * 2022-12-20 2023-04-18 绍兴市精益生物化工有限公司 α-酮戊二酸钙盐制备方法
CN119977789A (zh) * 2025-02-12 2025-05-13 江苏惠利生物科技有限公司 一种离子交换树脂制备高纯度α-酮戊二酸钙的方法

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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4632921A (en) * 1981-12-23 1986-12-30 Bauer Kurt H Process for the production of readily soluble 5-aminosalicylic acid preparations
US8183409B2 (en) * 2004-05-06 2012-05-22 Osteologix A/S High yield and rapid synthesis methods for producing metallo-organic salts
CN102976927A (zh) * 2012-12-26 2013-03-20 天津天成制药有限公司 α-酮戊二酸钙的制备方法

Also Published As

Publication number Publication date
US11802103B2 (en) 2023-10-31
US20210371368A1 (en) 2021-12-02
KR102833111B1 (ko) 2025-07-10
JP7499259B2 (ja) 2024-06-13
IL281761B1 (en) 2025-05-01
PE20211816A1 (es) 2021-09-14
CO2021004529A2 (es) 2021-04-30
TWI863930B (zh) 2024-12-01
SG11202102204PA (en) 2021-04-29
WO2020068705A1 (en) 2020-04-02
JP2022502489A (ja) 2022-01-11
CN112955139B (zh) 2025-04-18
EP3856166A1 (en) 2021-08-04
KR20210065120A (ko) 2021-06-03
EP3856166A4 (en) 2022-06-22
MY203278A (en) 2024-06-21
PH12021550403A1 (en) 2021-10-04
CL2021000728A1 (es) 2021-10-22
BR112021005668A2 (pt) 2021-06-22
MX2021003482A (es) 2021-06-18
TW202024013A (zh) 2020-07-01
IL281761A (en) 2021-05-31
AU2019350699B2 (en) 2024-05-23
AU2019350699A1 (en) 2021-04-08
CN112955139A (zh) 2021-06-11
CA3112205A1 (en) 2020-04-02

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