CN1121224C - 含有抗－Xa活性化合物和血小板聚集拮抗化合物的药物组合物 - Google Patents

含有抗－Xa活性化合物和血小板聚集拮抗化合物的药物组合物 Download PDF

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Publication number
CN1121224C
CN1121224C CN97180019A CN97180019A CN1121224C CN 1121224 C CN1121224 C CN 1121224C CN 97180019 A CN97180019 A CN 97180019A CN 97180019 A CN97180019 A CN 97180019A CN 1121224 C CN1121224 C CN 1121224C
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CN
China
Prior art keywords
compound
platelet aggregation
antagonistic
piperidin
active compound
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Expired - Fee Related
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CN97180019A
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English (en)
Chinese (zh)
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CN1238693A (zh
Inventor
A·尤赞
A·H·库拉迪尤
R·J·莱德雷
C·T·邓维迪
M·H·普罗恩
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Aventis Pharmaceuticals Inc
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Hoechst Marion Roussel Inc
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Publication of CN1238693A publication Critical patent/CN1238693A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN97180019A 1996-11-27 1997-11-24 含有抗－Xa活性化合物和血小板聚集拮抗化合物的药物组合物 Expired - Fee Related CN1121224C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3187896P 1996-11-27 1996-11-27
US60/031,878 1996-11-27

Publications (2)

Publication Number Publication Date
CN1238693A CN1238693A (zh) 1999-12-15
CN1121224C true CN1121224C (zh) 2003-09-17

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ID=21861879

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CN97180019A Expired - Fee Related CN1121224C (zh) 1996-11-27 1997-11-24 含有抗－Xa活性化合物和血小板聚集拮抗化合物的药物组合物

Country Status (27)

Country Link
US (2) US6103705A (enExample)
EP (1) EP0946185B2 (enExample)
JP (1) JP4498471B2 (enExample)
KR (1) KR100512671B1 (enExample)
CN (1) CN1121224C (enExample)
AP (1) AP1390A (enExample)
AT (1) ATE283062T1 (enExample)
AU (1) AU754936B2 (enExample)
BG (1) BG64542B1 (enExample)
BR (1) BR9713141A (enExample)
CA (1) CA2272317C (enExample)
CZ (1) CZ298552B6 (enExample)
DE (1) DE69731763T3 (enExample)
DK (1) DK0946185T4 (enExample)
EA (1) EA002475B1 (enExample)
ES (1) ES2230624T5 (enExample)
HU (1) HUP9903496A3 (enExample)
IL (1) IL129877A (enExample)
NO (1) NO327740B1 (enExample)
OA (1) OA11049A (enExample)
PL (1) PL189116B1 (enExample)
PT (1) PT946185E (enExample)
SI (1) SI0946185T2 (enExample)
SK (1) SK286024B6 (enExample)
UA (1) UA63929C2 (enExample)
WO (1) WO1998023279A1 (enExample)
ZA (1) ZA9710691B (enExample)

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US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
ES2274013T3 (es) 2001-01-26 2007-05-16 Schering Corporation Combinaciones de activador(es) del receptor activado por el proliferador de los peroxisomas (ppar) e inhibidor(es)m de la absorcion de estelores y tratamientos para trastornos vasculares.
CA2434430A1 (en) 2001-01-26 2002-08-01 Harry R. Davis The use of substituted azetidinone compounds for the treatment of sitosterolemia
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US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US20040171819A1 (en) * 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
WO2004043457A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN1756756A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
WO2004081004A1 (en) 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7235543B2 (en) 2003-03-07 2007-06-26 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7956046B2 (en) * 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
EP1537871A1 (en) * 2003-12-04 2005-06-08 Aventis Pharma S.A. Enoxaparin for the treatment of cancer
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
KR100601429B1 (ko) * 2004-07-09 2006-07-14 주식회사 대우일렉트로닉스 기계식 전자렌지의 댐퍼 구동회로
EP2014296A1 (en) * 2007-07-10 2009-01-14 PAION Deutschland GmbH Novel strategies for increasing the reperfusion in obstructed blood vessel
AR067345A1 (es) * 2007-07-10 2009-10-07 Paion Deutschland Gmbh Uso de trombomodulina para la preparacion de un medicamento trombolitico
CN101783857B (zh) * 2009-05-12 2011-11-30 上海海事大学 一种基于fpga在高分辨率成像系统中的图像矩阵化预处理方法
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RU2554803C1 (ru) * 2014-06-26 2015-06-27 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ профилактики развития послеоперационных венозных тромбоэмболических осложнений у пациентов с колоректальным раком

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Also Published As

Publication number Publication date
CN1238693A (zh) 1999-12-15
NO327740B1 (no) 2009-09-14
PL189116B1 (pl) 2005-06-30
DE69731763D1 (de) 2004-12-30
AU754936B2 (en) 2002-11-28
US20020032214A1 (en) 2002-03-14
SI0946185T1 (en) 2005-06-30
CZ298552B6 (cs) 2007-10-31
EP0946185B2 (en) 2010-05-05
DK0946185T3 (da) 2005-03-21
EA002475B1 (ru) 2002-06-27
DK0946185T4 (da) 2010-08-30
JP4498471B2 (ja) 2010-07-07
SK67399A3 (en) 2000-07-11
ATE283062T1 (de) 2004-12-15
BR9713141A (pt) 2000-02-08
DE69731763T3 (de) 2010-12-30
HUP9903496A3 (en) 2001-03-28
HK1023504A1 (en) 2000-09-15
AP9901517A0 (en) 1999-06-30
KR100512671B1 (ko) 2005-09-07
HUP9903496A2 (hu) 2000-10-28
UA63929C2 (uk) 2004-02-16
JP2001506603A (ja) 2001-05-22
NO992555D0 (no) 1999-05-27
IL129877A (en) 2004-08-31
AP1390A (en) 2005-04-15
ES2230624T5 (es) 2010-10-25
OA11049A (en) 2002-02-18
CA2272317C (en) 2001-01-30
NO992555L (no) 1999-05-27
CZ174299A3 (cs) 1999-09-15
PT946185E (pt) 2005-02-28
US6103705A (en) 2000-08-15
KR20000057265A (ko) 2000-09-15
BG64542B1 (bg) 2005-07-29
EP0946185B1 (en) 2004-11-24
BG103372A (en) 2000-01-31
WO1998023279A1 (en) 1998-06-04
ZA9710691B (en) 1998-06-12
ES2230624T3 (es) 2005-05-01
AU5454698A (en) 1998-06-22
SI0946185T2 (sl) 2010-08-31
EP0946185A1 (en) 1999-10-06
IL129877A0 (en) 2000-02-29
EA199900499A1 (ru) 2000-04-24
DE69731763T2 (de) 2005-06-30
EP0946185A4 (en) 2001-06-27
SK286024B6 (sk) 2008-01-07

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