CN111655709B - 抗菌氨基糖苷类似物的合成 - Google Patents

抗菌氨基糖苷类似物的合成 Download PDF

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Publication number
CN111655709B
CN111655709B CN201880081473.5A CN201880081473A CN111655709B CN 111655709 B CN111655709 B CN 111655709B CN 201880081473 A CN201880081473 A CN 201880081473A CN 111655709 B CN111655709 B CN 111655709B
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formula
compound
enantiomer
salt
diastereomer
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Chinese (zh)
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CN111655709A (zh
Inventor
瑞莎·特雷德
迈克尔·达彭
克里斯托弗·E·亨利
亚当·亚伦·戈德布卢姆
詹姆士·布拉德利·阿根
里卡多·菲利佩·德·杰西·戈萨尔维斯·门顿切亚
若昂·卡洛斯·法尔孔·萨尔迪尼亚
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Xuanzhu Beijing Pharm Co Ltd
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Xuanzhu Beijing Pharm Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201880081473.5A 2017-10-19 2018-10-18 抗菌氨基糖苷类似物的合成 Active CN111655709B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762574544P 2017-10-19 2017-10-19
US62/574,544 2017-10-19
PCT/US2018/056536 WO2019079613A1 (en) 2017-10-19 2018-10-18 SYNTHESIS OF ANTIBACTERIAL AMINOGLYCOSIDE ANALOGUES

Publications (2)

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CN111655709A CN111655709A (zh) 2020-09-11
CN111655709B true CN111655709B (zh) 2024-01-02

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US (3) US11453658B2 (https=)
EP (1) EP3697797A1 (https=)
JP (3) JP7235741B2 (https=)
CN (1) CN111655709B (https=)
AR (1) AR113780A1 (https=)
AU (2) AU2023219819B2 (https=)
CA (1) CA3079508A1 (https=)
EA (1) EA202090980A1 (https=)
MX (1) MX2020003701A (https=)
TW (1) TWI801438B (https=)
WO (1) WO2019079613A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019079613A1 (en) * 2017-10-19 2019-04-25 Achaogen, Inc. SYNTHESIS OF ANTIBACTERIAL AMINOGLYCOSIDE ANALOGUES
CN110878108B (zh) * 2019-06-17 2022-11-11 山东安信制药有限公司 一种普拉佐米星的合成方法
CN110885350A (zh) * 2019-08-28 2020-03-17 山东安信制药有限公司 一种普拉佐米星的制备方法
CN110642907B (zh) * 2019-10-12 2020-11-06 上海博璞诺科技发展有限公司 普拉唑米星或其盐的合成方法
CN111116688B (zh) * 2020-01-07 2021-07-27 杭州华东医药集团新药研究院有限公司 普拉佐米星的制备方法
CN111205341A (zh) * 2020-02-17 2020-05-29 山东安信制药有限公司 一种普拉佐米星关键中间体的制备方法
CN112079882B (zh) * 2020-10-10 2021-10-08 山东安信制药有限公司 一种Plazomicin的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101868472A (zh) * 2007-11-21 2010-10-20 尔察祯有限公司 抗菌性氨基糖苷类似物
WO2010132770A1 (en) * 2009-05-14 2010-11-18 Achaogen, Inc. Treatment of klebsiella pneumoniae infections with antibacterial aminoglycoside compounds
WO2010132777A2 (en) * 2009-05-14 2010-11-18 Achaogen, Inc. Treatment of urinary tract infections with antibacterial aminoglycoside compounds
WO2010147836A1 (en) * 2009-06-17 2010-12-23 Achaogen, Inc. Combination therapies using antibacterial aminoglycoside compounds
CN103003293A (zh) * 2010-05-12 2013-03-27 莱姆派克斯制药公司 氨基糖苷衍生物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4388233A (en) * 1981-05-15 1983-06-14 The Regents Of The University Of California Synthetic substrates for enzyme analysis
MX2009003909A (es) 2006-10-12 2009-05-25 Ptc Therapeutics Inc Métodos para dosificar un compuesto 1,2,4, - oxadiazol oralmente activo para el tratamiento de supresión de la mutación finalizadora.
US8614233B2 (en) * 2007-05-29 2013-12-24 Universite De Montreal Cinnamoyl inhibitors of transglutaminase
EP2103602A1 (en) * 2008-03-17 2009-09-23 AEterna Zentaris GmbH Novel 1,2,4-triazole derivatives and process of manufacturing thereof
US9238670B2 (en) * 2013-03-15 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Aminoglycoside antibiotics with reduced ototoxicity
WO2019079613A1 (en) * 2017-10-19 2019-04-25 Achaogen, Inc. SYNTHESIS OF ANTIBACTERIAL AMINOGLYCOSIDE ANALOGUES

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101868472A (zh) * 2007-11-21 2010-10-20 尔察祯有限公司 抗菌性氨基糖苷类似物
WO2010132770A1 (en) * 2009-05-14 2010-11-18 Achaogen, Inc. Treatment of klebsiella pneumoniae infections with antibacterial aminoglycoside compounds
WO2010132777A2 (en) * 2009-05-14 2010-11-18 Achaogen, Inc. Treatment of urinary tract infections with antibacterial aminoglycoside compounds
CN102481307A (zh) * 2009-05-14 2012-05-30 尔察祯有限公司 使用抗菌氨基糖苷化合物治疗肺炎克雷伯杆菌感染
WO2010147836A1 (en) * 2009-06-17 2010-12-23 Achaogen, Inc. Combination therapies using antibacterial aminoglycoside compounds
CN103003293A (zh) * 2010-05-12 2013-03-27 莱姆派克斯制药公司 氨基糖苷衍生物

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Publication number Publication date
AR113780A1 (es) 2020-06-10
CN111655709A (zh) 2020-09-11
US12122769B2 (en) 2024-10-22
US20250122177A1 (en) 2025-04-17
US20230074115A1 (en) 2023-03-09
AU2018353156A1 (en) 2020-05-07
EP3697797A1 (en) 2020-08-26
JP2025062009A (ja) 2025-04-11
MX2020003701A (es) 2020-07-22
EA202090980A1 (ru) 2020-10-07
JP2021500354A (ja) 2021-01-07
WO2019079613A1 (en) 2019-04-25
CA3079508A1 (en) 2019-04-25
US20200317652A1 (en) 2020-10-08
RU2020116171A (ru) 2021-11-19
AU2023219819A1 (en) 2023-09-07
BR112020007740A2 (pt) 2020-10-13
AU2025226793A1 (en) 2025-09-25
JP2023054316A (ja) 2023-04-13
TWI801438B (zh) 2023-05-11
JP7235741B2 (ja) 2023-03-08
US11453658B2 (en) 2022-09-27
TW201922233A (zh) 2019-06-16
RU2020116171A3 (https=) 2022-03-03
AU2023219819B2 (en) 2025-06-05

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