MX2020003701A - Sintesis de analogos de aminoglucosidos antibacterianos. - Google Patents

Sintesis de analogos de aminoglucosidos antibacterianos.

Info

Publication number
MX2020003701A
MX2020003701A MX2020003701A MX2020003701A MX2020003701A MX 2020003701 A MX2020003701 A MX 2020003701A MX 2020003701 A MX2020003701 A MX 2020003701A MX 2020003701 A MX2020003701 A MX 2020003701A MX 2020003701 A MX2020003701 A MX 2020003701A
Authority
MX
Mexico
Prior art keywords
synthesis
antibacterial aminoglycoside
aminoglycoside analogs
analogs
antibacterial
Prior art date
Application number
MX2020003701A
Other languages
English (en)
Inventor
James Bradley Aggen
Raissa Trend
Michael Dappen
Christopher E Henry
Adam Aaron Goldblum
Ricardo Filipe De Jesus Gonçalves Mendonça
João Carlos Falcão Sardinha
Original Assignee
Cipla Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Usa Inc filed Critical Cipla Usa Inc
Publication of MX2020003701A publication Critical patent/MX2020003701A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente descripción se relaciona con métodos nuevos para la preparación de compuestos de aminoglúcosidos antibacterianos, así como también con intermedios relacionados y formas cristalinas de estos útiles en los métodos.
MX2020003701A 2017-10-19 2018-10-18 Sintesis de analogos de aminoglucosidos antibacterianos. MX2020003701A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762574544P 2017-10-19 2017-10-19
PCT/US2018/056536 WO2019079613A1 (en) 2017-10-19 2018-10-18 SYNTHESIS OF ANTIBACTERIAL AMINOGLYCOSIDE ANALOGUES

Publications (1)

Publication Number Publication Date
MX2020003701A true MX2020003701A (es) 2020-07-22

Family

ID=64110232

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020003701A MX2020003701A (es) 2017-10-19 2018-10-18 Sintesis de analogos de aminoglucosidos antibacterianos.

Country Status (12)

Country Link
US (2) US11453658B2 (es)
EP (1) EP3697797A1 (es)
JP (2) JP7235741B2 (es)
CN (1) CN111655709B (es)
AR (1) AR113780A1 (es)
AU (1) AU2023219819A1 (es)
BR (1) BR112020007740A2 (es)
CA (1) CA3079508A1 (es)
EA (1) EA202090980A1 (es)
MX (1) MX2020003701A (es)
TW (1) TWI801438B (es)
WO (1) WO2019079613A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110878108B (zh) * 2019-06-17 2022-11-11 山东安信制药有限公司 一种普拉佐米星的合成方法
CN110885350A (zh) * 2019-08-28 2020-03-17 山东安信制药有限公司 一种普拉佐米星的制备方法
CN110642907B (zh) * 2019-10-12 2020-11-06 上海博璞诺科技发展有限公司 普拉唑米星或其盐的合成方法
CN111116688B (zh) * 2020-01-07 2021-07-27 杭州华东医药集团新药研究院有限公司 普拉佐米星的制备方法
CN111205341A (zh) * 2020-02-17 2020-05-29 山东安信制药有限公司 一种普拉佐米星关键中间体的制备方法
CN112079882B (zh) * 2020-10-10 2021-10-08 山东安信制药有限公司 一种Plazomicin的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4388233A (en) * 1981-05-15 1983-06-14 The Regents Of The University Of California Synthetic substrates for enzyme analysis
JP2010506840A (ja) 2006-10-12 2010-03-04 ピーティーシー セラピューティクス，インコーポレーテッド ナンセンス突然変異抑制治療用の経口的に活性な１，２，４−オキサジアゾールの投与方法
WO2008144933A1 (en) * 2007-05-29 2008-12-04 Université de Montréal Cinnamoyl inhibitors of transglutaminase
AU2008326297B2 (en) * 2007-11-21 2012-11-08 Cipla USA, Inc. Antibacterial aminoglycoside analogs
EP2103602A1 (en) * 2008-03-17 2009-09-23 AEterna Zentaris GmbH Novel 1,2,4-triazole derivatives and process of manufacturing thereof
CN106188175B (zh) 2009-05-14 2020-08-11 轩竹(北京)医药科技有限公司 使用抗菌氨基糖苷化合物治疗肺炎克雷伯杆菌感染
CN102481306A (zh) * 2009-05-14 2012-05-30 尔察祯有限公司 使用抗菌氨基糖苷化合物治疗尿路感染
WO2010147836A1 (en) * 2009-06-17 2010-12-23 Achaogen, Inc. Combination therapies using antibacterial aminoglycoside compounds
CN103003293A (zh) * 2010-05-12 2013-03-27 莱姆派克斯制药公司 氨基糖苷衍生物
US9238670B2 (en) * 2013-03-15 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Aminoglycoside antibiotics with reduced ototoxicity

Also Published As

Publication number Publication date
EP3697797A1 (en) 2020-08-26
TWI801438B (zh) 2023-05-11
AU2018353156A1 (en) 2020-05-07
WO2019079613A1 (en) 2019-04-25
TW201922233A (zh) 2019-06-16
CN111655709B (zh) 2024-01-02
JP2023054316A (ja) 2023-04-13
AR113780A1 (es) 2020-06-10
EA202090980A1 (ru) 2020-10-07
US20200317652A1 (en) 2020-10-08
JP7235741B2 (ja) 2023-03-08
JP2021500354A (ja) 2021-01-07
CN111655709A (zh) 2020-09-11
BR112020007740A2 (pt) 2020-10-13
CA3079508A1 (en) 2019-04-25
US20230074115A1 (en) 2023-03-09
RU2020116171A3 (es) 2022-03-03
RU2020116171A (ru) 2021-11-19
AU2023219819A1 (en) 2023-09-07
US11453658B2 (en) 2022-09-27

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