AR113780A1 - Síntesis de análogos de aminoglicósidos antibacterianos - Google Patents
Síntesis de análogos de aminoglicósidos antibacterianosInfo
- Publication number
- AR113780A1 AR113780A1 ARP180103039A ARP180103039A AR113780A1 AR 113780 A1 AR113780 A1 AR 113780A1 AR P180103039 A ARP180103039 A AR P180103039A AR P180103039 A ARP180103039 A AR P180103039A AR 113780 A1 AR113780 A1 AR 113780A1
- Authority
- AR
- Argentina
- Prior art keywords
- analogues
- synthesis
- antibacterial aminoglycoside
- diastereomers
- enantiomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Reivindicación 1: Un proceso para preparar un compuesto de la fórmula (2), o una de sus sales, o uno de sus solvatos, o uno de sus enantiómeros, o uno de sus diastereómeros, caracterizado porque comprende: (a) poner en contacto un compuesto de fórmula (1), o uno de sus enantiómeros, o uno de sus diastereómeros, con 1-{[(p-nitrobencil)oxi]carbonil}-1H-benzotriazol (PNZ-Bt) para formar el compuesto de la fórmula (2), o una de sus sales, o uno de sus solvatos, o uno de sus enantiómeros, o uno de sus diastereómeros; donde ⁻ ⁻ ⁻ es un enlace simple o un enlace doble; R¹ es H o C₁₋₃ alquilo; R² es H o C₁₋₃ alquilo; y R³ es H o C₁₋₃ alquilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762574544P | 2017-10-19 | 2017-10-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR113780A1 true AR113780A1 (es) | 2020-06-10 |
Family
ID=64110232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180103039A AR113780A1 (es) | 2017-10-19 | 2018-10-18 | Síntesis de análogos de aminoglicósidos antibacterianos |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11453658B2 (es) |
| EP (1) | EP3697797A1 (es) |
| JP (2) | JP7235741B2 (es) |
| CN (1) | CN111655709B (es) |
| AR (1) | AR113780A1 (es) |
| AU (1) | AU2023219819A1 (es) |
| BR (1) | BR112020007740A2 (es) |
| CA (1) | CA3079508A1 (es) |
| EA (1) | EA202090980A1 (es) |
| MX (1) | MX2020003701A (es) |
| TW (1) | TWI801438B (es) |
| WO (1) | WO2019079613A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110878108B (zh) * | 2019-06-17 | 2022-11-11 | 山东安信制药有限公司 | 一种普拉佐米星的合成方法 |
| CN110885350A (zh) * | 2019-08-28 | 2020-03-17 | 山东安信制药有限公司 | 一种普拉佐米星的制备方法 |
| CN110642907B (zh) * | 2019-10-12 | 2020-11-06 | 上海博璞诺科技发展有限公司 | 普拉唑米星或其盐的合成方法 |
| CN111116688B (zh) * | 2020-01-07 | 2021-07-27 | 杭州华东医药集团新药研究院有限公司 | 普拉佐米星的制备方法 |
| CN111205341A (zh) * | 2020-02-17 | 2020-05-29 | 山东安信制药有限公司 | 一种普拉佐米星关键中间体的制备方法 |
| CN112079882B (zh) * | 2020-10-10 | 2021-10-08 | 山东安信制药有限公司 | 一种Plazomicin的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4388233A (en) * | 1981-05-15 | 1983-06-14 | The Regents Of The University Of California | Synthetic substrates for enzyme analysis |
| JP2010506840A (ja) | 2006-10-12 | 2010-03-04 | ピーティーシー セラピューティクス，インコーポレーテッド | ナンセンス突然変異抑制治療用の経口的に活性な１，２，４−オキサジアゾールの投与方法 |
| WO2008144933A1 (en) * | 2007-05-29 | 2008-12-04 | Université de Montréal | Cinnamoyl inhibitors of transglutaminase |
| AU2008326297B2 (en) * | 2007-11-21 | 2012-11-08 | Cipla USA, Inc. | Antibacterial aminoglycoside analogs |
| EP2103602A1 (en) * | 2008-03-17 | 2009-09-23 | AEterna Zentaris GmbH | Novel 1,2,4-triazole derivatives and process of manufacturing thereof |
| CN106188175B (zh) | 2009-05-14 | 2020-08-11 | 轩竹(北京)医药科技有限公司 | 使用抗菌氨基糖苷化合物治疗肺炎克雷伯杆菌感染 |
| CN102481306A (zh) * | 2009-05-14 | 2012-05-30 | 尔察祯有限公司 | 使用抗菌氨基糖苷化合物治疗尿路感染 |
| WO2010147836A1 (en) * | 2009-06-17 | 2010-12-23 | Achaogen, Inc. | Combination therapies using antibacterial aminoglycoside compounds |
| CN103003293A (zh) * | 2010-05-12 | 2013-03-27 | 莱姆派克斯制药公司 | 氨基糖苷衍生物 |
| US9238670B2 (en) * | 2013-03-15 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Aminoglycoside antibiotics with reduced ototoxicity |
-
2018
- 2018-10-18 AR ARP180103039A patent/AR113780A1/es unknown
- 2018-10-18 CN CN201880081473.5A patent/CN111655709B/zh active Active
- 2018-10-18 EA EA202090980A patent/EA202090980A1/ru unknown
- 2018-10-18 CA CA3079508A patent/CA3079508A1/en active Pending
- 2018-10-18 WO PCT/US2018/056536 patent/WO2019079613A1/en unknown
- 2018-10-18 TW TW107136676A patent/TWI801438B/zh active
- 2018-10-18 BR BR112020007740-2A patent/BR112020007740A2/pt unknown
- 2018-10-18 JP JP2020522054A patent/JP7235741B2/ja active Active
- 2018-10-18 MX MX2020003701A patent/MX2020003701A/es unknown
- 2018-10-18 EP EP18797440.7A patent/EP3697797A1/en active Pending
-
2020
- 2020-04-16 US US16/850,771 patent/US11453658B2/en active Active
-
2022
- 2022-08-04 US US17/881,462 patent/US20230074115A1/en active Pending
-
2023
- 2023-02-24 JP JP2023027439A patent/JP2023054316A/ja active Pending
- 2023-08-22 AU AU2023219819A patent/AU2023219819A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3697797A1 (en) | 2020-08-26 |
| TWI801438B (zh) | 2023-05-11 |
| AU2018353156A1 (en) | 2020-05-07 |
| WO2019079613A1 (en) | 2019-04-25 |
| TW201922233A (zh) | 2019-06-16 |
| CN111655709B (zh) | 2024-01-02 |
| JP2023054316A (ja) | 2023-04-13 |
| EA202090980A1 (ru) | 2020-10-07 |
| US20200317652A1 (en) | 2020-10-08 |
| JP7235741B2 (ja) | 2023-03-08 |
| JP2021500354A (ja) | 2021-01-07 |
| CN111655709A (zh) | 2020-09-11 |
| MX2020003701A (es) | 2020-07-22 |
| BR112020007740A2 (pt) | 2020-10-13 |
| CA3079508A1 (en) | 2019-04-25 |
| US20230074115A1 (en) | 2023-03-09 |
| RU2020116171A3 (es) | 2022-03-03 |
| RU2020116171A (ru) | 2021-11-19 |
| AU2023219819A1 (en) | 2023-09-07 |
| US11453658B2 (en) | 2022-09-27 |
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