AR106958A1 - Derivados de tetrahidrotriazolopirimidina útiles como inhibidores de hne - Google Patents

Derivados de tetrahidrotriazolopirimidina útiles como inhibidores de hne

Info

Publication number
AR106958A1
AR106958A1 ARP160103797A ARP160103797A AR106958A1 AR 106958 A1 AR106958 A1 AR 106958A1 AR P160103797 A ARP160103797 A AR P160103797A AR P160103797 A ARP160103797 A AR P160103797A AR 106958 A1 AR106958 A1 AR 106958A1
Authority
AR
Argentina
Prior art keywords
tetrahydrotriazolopirimidine
derivatives
useful
hne inhibitors
hne
Prior art date
Application number
ARP160103797A
Other languages
English (en)
Inventor
Capaldi Carmelida
Armani Elisabetta
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of AR106958A1 publication Critical patent/AR106958A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), donde R¹ es -C₁₋₆-alquilo opcionalmente sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en -CO₂R², SO₂R², -NHC(O)R², y -OR²; R² es hidrógeno o -C₁₋₆-alquilo; y sales aceptables farmacéuticamente del mismo.
ARP160103797A 2015-12-14 2016-12-12 Derivados de tetrahidrotriazolopirimidina útiles como inhibidores de hne AR106958A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15199816 2015-12-14

Publications (1)

Publication Number Publication Date
AR106958A1 true AR106958A1 (es) 2018-03-07

Family

ID=54849834

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160103797A AR106958A1 (es) 2015-12-14 2016-12-12 Derivados de tetrahidrotriazolopirimidina útiles como inhibidores de hne

Country Status (4)

Country Link
US (1) US9890169B2 (es)
EP (1) EP3390405B1 (es)
AR (1) AR106958A1 (es)
WO (1) WO2017102674A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022004861A2 (pt) 2019-09-17 2022-06-07 Univ Duke Alvelestat para uso no tratamento de rejeição de transplante, síndrome de bronquiolite obliterante e doença de transplante versus hospedeiro
IL297211A (en) 2020-04-16 2022-12-01 Mereo Biopharma 4 Ltd Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency
TW202325294A (zh) 2021-10-20 2023-07-01 英商梅瑞奧生物製藥４有限公司 用於治療纖維化之嗜中性球彈性蛋白酶抑制劑

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US217306A (en) 1879-07-08 Improvement in bee-hives
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
DE102009004197A1 (de) 2009-01-09 2010-07-15 Bayer Schering Pharma Aktiengesellschaft Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung
GB201004179D0 (en) 2010-03-12 2010-04-28 Pulmagen Therapeutics Inflamma Enzyme inhibitors
GB201004178D0 (en) 2010-03-12 2010-04-28 Pulmagen Therapeutics Inflamma Enzyme inhibitors
CA2848557A1 (en) 2011-09-14 2013-03-21 Chiesi Farmaceutici S.P.A. Tetrahydrotriazolopyrimidine derivatives as human neutrophil elastase inhibitors
NZ709153A (en) 2012-12-18 2019-01-25 Chiesi Farm Spa Pyrimidinone derivatives having human neutrophil elastase inhibitory activity
CA2933725A1 (en) 2013-12-16 2015-06-25 Chiesi Farmaceutici S.P.A. Tetrahydrotriazolopyrimidine derivatives as human neutrophil elastase inhibitors

Also Published As

Publication number Publication date
US20170166574A1 (en) 2017-06-15
US9890169B2 (en) 2018-02-13
WO2017102674A1 (en) 2017-06-22
EP3390405B1 (en) 2020-07-15
EP3390405A1 (en) 2018-10-24

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