AR106958A1 - Derivados de tetrahidrotriazolopirimidina útiles como inhibidores de hne - Google Patents

Derivados de tetrahidrotriazolopirimidina útiles como inhibidores de hne

Info

Publication number
AR106958A1
AR106958A1 ARP160103797A ARP160103797A AR106958A1 AR 106958 A1 AR106958 A1 AR 106958A1 AR P160103797 A ARP160103797 A AR P160103797A AR P160103797 A ARP160103797 A AR P160103797A AR 106958 A1 AR106958 A1 AR 106958A1
Authority
AR
Argentina
Prior art keywords
tetrahydrotriazolopirimidine
derivatives
useful
hne inhibitors
hne
Prior art date
Application number
ARP160103797A
Other languages
English (en)
Inventor
Capaldi Carmelida
Armani Elisabetta
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of AR106958A1 publication Critical patent/AR106958A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), donde R¹ es -C₁₋₆-alquilo opcionalmente sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en -CO₂R², SO₂R², -NHC(O)R², y -OR²; R² es hidrógeno o -C₁₋₆-alquilo; y sales aceptables farmacéuticamente del mismo.
ARP160103797A 2015-12-14 2016-12-12 Derivados de tetrahidrotriazolopirimidina útiles como inhibidores de hne AR106958A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15199816 2015-12-14

Publications (1)

Publication Number Publication Date
AR106958A1 true AR106958A1 (es) 2018-03-07

Family

ID=54849834

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160103797A AR106958A1 (es) 2015-12-14 2016-12-12 Derivados de tetrahidrotriazolopirimidina útiles como inhibidores de hne

Country Status (4)

Country Link
US (1) US9890169B2 (es)
EP (1) EP3390405B1 (es)
AR (1) AR106958A1 (es)
WO (1) WO2017102674A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220354833A1 (en) 2019-09-17 2022-11-10 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
ES2962498T3 (es) 2020-04-16 2024-03-19 Mereo Biopharma 4 Ltd Métodos que implican el inhibidor de elastasa de neutrófilos alvelestat para el tratamiento de enfermedades respiratorias mediadas por deficiencia de alfa-1 antitripsina
US20240382472A1 (en) 2021-10-20 2024-11-21 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US217306A (en) 1879-07-08 Improvement in bee-hives
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
DE102009004197A1 (de) 2009-01-09 2010-07-15 Bayer Schering Pharma Aktiengesellschaft Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung
GB201004179D0 (en) 2010-03-12 2010-04-28 Pulmagen Therapeutics Inflamma Enzyme inhibitors
GB201004178D0 (en) 2010-03-12 2010-04-28 Pulmagen Therapeutics Inflamma Enzyme inhibitors
CN103827117B (zh) 2011-09-14 2016-08-24 奇斯药制品公司 作为人嗜中性粒细胞弹性蛋白酶抑制剂的四氢三唑并嘧啶衍生物
EP2935274B1 (en) 2012-12-18 2018-10-03 Chiesi Farmaceutici S.p.A. 3-oxo-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine derivatives for the treatmetn of respiratory diseases
WO2015091281A1 (en) 2013-12-16 2015-06-25 Chiesi Farmaceutici S.P.A. Tetrahydrotriazolopyrimidine derivatives as human neutrophil elastase inhibitors

Also Published As

Publication number Publication date
US9890169B2 (en) 2018-02-13
EP3390405B1 (en) 2020-07-15
US20170166574A1 (en) 2017-06-15
EP3390405A1 (en) 2018-10-24
WO2017102674A1 (en) 2017-06-22

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