CN110431135A - 微管蛋白结合化合物及其治疗用途 - Google Patents

微管蛋白结合化合物及其治疗用途 Download PDF

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Publication number
CN110431135A
CN110431135A CN201880016232.2A CN201880016232A CN110431135A CN 110431135 A CN110431135 A CN 110431135A CN 201880016232 A CN201880016232 A CN 201880016232A CN 110431135 A CN110431135 A CN 110431135A
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CN
China
Prior art keywords
compound
atom
tubulin
moiety
alkyl
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CN201880016232.2A
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English (en)
Chinese (zh)
Inventor
黄岚
桑托什·安巴达斯·凯德卡尔
米歇尔·O·斯坦梅茨
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BeyondSpring Pharmaceuticals Inc
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BeyondSpring Pharmaceuticals Inc
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Publication of CN110431135A publication Critical patent/CN110431135A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Furan Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrane Compounds (AREA)
CN201880016232.2A 2017-01-06 2018-01-05 微管蛋白结合化合物及其治疗用途 Pending CN110431135A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762443247P 2017-01-06 2017-01-06
US62/443,247 2017-01-06
PCT/US2018/012668 WO2018129381A1 (en) 2017-01-06 2018-01-05 Tubulin binding compounds and therapeutic use thereof

Publications (1)

Publication Number Publication Date
CN110431135A true CN110431135A (zh) 2019-11-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880016232.2A Pending CN110431135A (zh) 2017-01-06 2018-01-05 微管蛋白结合化合物及其治疗用途

Country Status (5)

Country Link
US (2) US11633393B2 (https=)
EP (1) EP3565812B1 (https=)
JP (2) JP2020503363A (https=)
CN (1) CN110431135A (https=)
WO (1) WO2018129381A1 (https=)

Cited By (4)

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Publication number Priority date Publication date Assignee Title
CN111954532A (zh) * 2018-04-13 2020-11-17 上海交通大学医学院附属瑞金医院 杂芳基酰胺类化合物的抗肿瘤多药耐药性、治疗癌症的用途和蛋白质-药物分子复合物
CN113750088A (zh) * 2021-09-16 2021-12-07 中国人民解放军海军特色医学中心 杂环化合物在制备治疗溃疡性结肠炎药物中的应用
CN115715285A (zh) * 2020-04-27 2023-02-24 奧土择破利悟 作为ubr盒结构域配体的化合物
CN116568671A (zh) * 2020-10-16 2023-08-08 分子医学研究中心责任有限公司 杂环Cullin-RING泛素连接酶化合物及其用途

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US10155748B2 (en) 2015-07-13 2018-12-18 Beyondspring Pharmaceuticals, Inc. Plinabulin compositions
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RU2760348C2 (ru) 2016-06-06 2021-11-24 Бейондспринг Фармасьютикалс, Инк. Способ уменьшения нейтропении
JP2020503363A (ja) 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド チューブリン結合化合物およびその治療的使用
BR112019015974A2 (pt) 2017-02-01 2020-03-31 Beyondspring Pharmaceuticals, Inc. Método para reduzir neutropenia
KR20200112881A (ko) 2018-01-24 2020-10-05 비욘드스프링 파마수티컬스, 인코포레이티드. 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법
CA3109223A1 (en) * 2018-08-16 2020-02-20 Beyondspring Pharmaceuticals, Inc. Method and composition for stimulating immune response
US20220226335A1 (en) * 2019-04-24 2022-07-21 The Governors Of The University Of Alberta Non-Peptidic Heterocycle-Containing Compounds for the Treatment of Alzheimer?s Disease
EP4043436A4 (en) * 2019-09-05 2023-08-30 Lunan Pharmaceutical Group Corporation MAGL INHIBITOR, ITS MANUFACTURING PROCESS AND ITS USE
KR102304026B1 (ko) * 2020-02-03 2021-09-23 순천대학교 산학협력단 세포자멸사를 유도하는 치환된 아릴사이클로프로필우레아 화합물 및 이를 포함하는 항암용 조성물
CA3215047A1 (en) 2021-04-09 2022-10-13 Lan Huang Therapeutic compositions and methods for treating tumors
WO2023203174A1 (en) * 2022-04-20 2023-10-26 Proxygen Gmbh Heterocyclic cullin ring ubiquitin ligase compounds and uses thereof

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