BR0110745A - Compostos de piperazinadiona - Google Patents
Compostos de piperazinadionaInfo
- Publication number
- BR0110745A BR0110745A BR0110745-3A BR0110745A BR0110745A BR 0110745 A BR0110745 A BR 0110745A BR 0110745 A BR0110745 A BR 0110745A BR 0110745 A BR0110745 A BR 0110745A
- Authority
- BR
- Brazil
- Prior art keywords
- sym
- cyclyl
- heterocyclyl
- heteroaryl
- independently
- Prior art date
Links
- JTHRRMFZHSDGNJ-UHFFFAOYSA-N piperazine-2,3-dione Chemical class O=C1NCCNC1=O JTHRRMFZHSDGNJ-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
"COMPOSTOS DE PIPERAZINADIONA". Os compostos de piperazinadiona da fórmula (I), na qual cada dentre e independentemente, é uma ligação simples ou uma ligação dupla; A é H ou CH(R^ a^ R^ b^) quando <sym> é uma ligação simples ou C(R^ A^R^ b^) quando <sym> e uma ligação dupla; Z é R~ 3~0-(Ar)-B, onde B é CH(R^ c^) quando <sym> é uma ligação simples, ou C(R^ c^) quando <sym> é uma ligação dupla; Ar é heteroarila; e R~ 3~ é H, alquila, arila, heteroarila, C(O)R^ d^, C(O)OR^ d^, C(O)NR^ d^R^ e^, ou SO~ 2~R^ d^ cada dentre R~ 1~ e R~ 2~, independentemente, é H C(O)R^ d^, C(O)OR^ d^, C(O)NR^ d^R^ e^, ou SO~ 2~R^ d^; e cada dentre R^ a^, R^ b^, R^ c^, R^ d^ e R^ e^, independentemente, é H, alquila, arila, heteroarila, ciclila ou heterociclila. Opcionalmente, R^ a^ e R^ b^ tomados juntamente são ciclila ou heterociclila; e, também opcionalmente, R~ 1~ e R^ a^ ou R~ 1~ e R^ b^ tomados juntamente são ciclila ou heterociclila.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30419100P | 2000-05-09 | 2000-05-09 | |
PCT/US2001/014721 WO2001095858A2 (en) | 2000-05-09 | 2001-05-08 | Piperazinedione compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0110745A true BR0110745A (pt) | 2003-12-30 |
Family
ID=23175471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0110745-3A BR0110745A (pt) | 2000-05-09 | 2001-05-08 | Compostos de piperazinadiona |
Country Status (14)
Country | Link |
---|---|
US (1) | US6635649B2 (pt) |
EP (1) | EP1282609B1 (pt) |
JP (1) | JP5101781B2 (pt) |
KR (1) | KR100852965B1 (pt) |
CN (1) | CN100522949C (pt) |
AT (1) | ATE417614T1 (pt) |
BR (1) | BR0110745A (pt) |
CZ (1) | CZ301743B6 (pt) |
DE (1) | DE60137037D1 (pt) |
HU (1) | HUP0302358A3 (pt) |
NO (1) | NO326341B1 (pt) |
RU (1) | RU2269520C2 (pt) |
WO (1) | WO2001095858A2 (pt) |
ZA (1) | ZA200209917B (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7288545B2 (en) * | 2000-05-09 | 2007-10-30 | Angiorx Corporation | Piperazinedione compounds |
WO2002011676A2 (en) | 2000-08-04 | 2002-02-14 | Dmi Biosciences, Inc. | Method of using diketopiperazines and composition containing them |
US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
US7935704B2 (en) * | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
EP1571970B1 (en) * | 2002-10-02 | 2011-08-17 | DMI Biosciences, Inc. | Diagnosis and monitoring of diseases |
WO2004103304A2 (en) * | 2003-05-15 | 2004-12-02 | Dmi Biosciences, Inc. | Treatment of t-cell mediated diseases |
AU2004275821A1 (en) * | 2003-09-25 | 2005-04-07 | Dmi Biosciences Inc. | Methods and products which utilize N-acyl-L-aspartic acid |
NZ548659A (en) * | 2004-02-04 | 2011-01-28 | Nereus Pharmaceuticals Inc | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
US8129527B2 (en) * | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
EP2300011A4 (en) * | 2008-05-27 | 2012-06-20 | Dmi Life Sciences Inc | METHODS AND THERAPEUTIC COMPOUNDS |
RU2519948C2 (ru) * | 2008-08-22 | 2014-06-20 | Бритиш Коламбиа Кэнсер Эйдженси Бранч | Низкомолекулярные ингибиторы n-концевой активации рецептора андрогенов |
EP2419424A4 (en) * | 2009-04-16 | 2014-01-08 | Telik Inc | SUBSTITUTED 4-AMINO-5-BENZOYL-2- (PHENYLAMINO) THIOPHEN-3-CARBONITRILES AND SUBSTITUTED 4-AMINO-5-BENZOYL-2- (PHENYLAMINO) THIOPHEN-3-CARBOXAMIDES AS TUBULIN POLYMERIZATION INHIBITORS |
JP2013537195A (ja) | 2010-09-07 | 2013-09-30 | ディエムアイ アクイジション コーポレイション | 疾患の治療 |
US8710062B2 (en) * | 2011-03-11 | 2014-04-29 | Taipei Medical University | Piperazinedione compounds |
KR102032400B1 (ko) | 2011-10-10 | 2019-10-15 | 앰피오 파마슈티컬스 인코퍼레이티드 | 퇴행성 관절 질환의 치료 |
CN103841934A (zh) | 2011-10-10 | 2014-06-04 | 安皮奥制药股份有限公司 | 增强免疫耐受的可植入的医疗装置及其制造与植入方法 |
EP2771007B1 (en) | 2011-10-28 | 2018-04-04 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
WO2014145729A2 (en) | 2013-03-15 | 2014-09-18 | Ampio Pharmaceuticals, Inc. | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
JP6311097B2 (ja) * | 2013-07-31 | 2018-04-18 | 学校法人東京薬科大学 | 微小管脱重合剤 |
EP4066836A1 (en) | 2014-08-18 | 2022-10-05 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
CN104356077B (zh) * | 2014-09-11 | 2016-09-14 | 中国科学院南海海洋研究所 | 一类不对称酰基保护的2,5-二酮哌嗪衍生物及其制备方法和应用 |
AU2016229294B2 (en) | 2015-03-06 | 2021-11-04 | Beyondspring Pharmaceuticals, Inc. | Method of treating cancer associated with a RAS mutation |
BR112017018964A2 (pt) | 2015-03-06 | 2018-05-22 | Beyondspring Pharmaceuticals Inc | uso de plinabulin e métodos para tratar tumor cerebral |
WO2016209969A1 (en) | 2015-06-22 | 2016-12-29 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
DK3334726T3 (da) | 2015-07-13 | 2022-05-16 | Beyondspring Pharmaceuticals Inc | Plinabulinsammensætninger |
CA3013467A1 (en) | 2016-02-08 | 2017-08-17 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
EP3463337A4 (en) | 2016-06-06 | 2020-02-12 | Beyondspring Pharmaceuticals, Inc. | COMPOSITION AND METHOD FOR REDUCING NEUTROPENIA |
WO2018129381A1 (en) | 2017-01-06 | 2018-07-12 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
BR112019015974A2 (pt) | 2017-02-01 | 2020-03-31 | Beyondspring Pharmaceuticals, Inc. | Método para reduzir neutropenia |
US11786523B2 (en) | 2018-01-24 | 2023-10-17 | Beyondspring Pharmaceuticals, Inc. | Composition and method for reducing thrombocytopenia |
CN109580801B (zh) * | 2018-06-26 | 2021-09-07 | 深圳海王医药科技研究院有限公司 | 一种检测微管蛋白抑制剂及相关杂质的高效液相色谱法 |
CN112010930B (zh) * | 2019-05-28 | 2022-08-02 | 首都医科大学 | Rgd修饰的五环哌嗪二酮及其制备和应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5973574A (ja) * | 1982-10-21 | 1984-04-25 | Grelan Pharmaceut Co Ltd | 環状ジペプチド類 |
GB8609908D0 (en) * | 1986-04-23 | 1986-05-29 | Fujisawa Pharmaceutical Co | Piperazine compound |
US4806538A (en) * | 1984-11-02 | 1989-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine compound as PAF-antagonist |
DK181687A (da) * | 1986-04-23 | 1987-10-24 | Fujisawa Pharmaceutical Co | Piperazinderivater og fremgangsmaade til fremstiling deraf |
GB9217331D0 (en) * | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
IL112627A0 (en) * | 1994-02-14 | 1995-05-26 | Xenova Ltd | Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them |
GB9402807D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
JP3795093B2 (ja) * | 1994-11-25 | 2006-07-12 | キッセイ薬品工業株式会社 | 1−ヒドロキシインドール誘導体 |
JP3131574B2 (ja) * | 1996-09-04 | 2001-02-05 | 新日本製鐵株式会社 | 新規抗腫瘍物質、該物質を製造するための微生物及び方法、並びに該物質を有効成分とする細胞周期阻害剤及び抗腫瘍剤 |
-
2001
- 2001-05-08 HU HU0302358A patent/HUP0302358A3/hu unknown
- 2001-05-08 JP JP2002510040A patent/JP5101781B2/ja not_active Expired - Fee Related
- 2001-05-08 BR BR0110745-3A patent/BR0110745A/pt not_active Application Discontinuation
- 2001-05-08 DE DE60137037T patent/DE60137037D1/de not_active Expired - Lifetime
- 2001-05-08 EP EP01975152A patent/EP1282609B1/en not_active Expired - Lifetime
- 2001-05-08 CZ CZ20023693A patent/CZ301743B6/cs not_active IP Right Cessation
- 2001-05-08 US US09/851,077 patent/US6635649B2/en not_active Expired - Fee Related
- 2001-05-08 RU RU2002132897/04A patent/RU2269520C2/ru not_active IP Right Cessation
- 2001-05-08 WO PCT/US2001/014721 patent/WO2001095858A2/en active IP Right Grant
- 2001-05-08 CN CNB018125212A patent/CN100522949C/zh not_active Expired - Fee Related
- 2001-05-08 KR KR1020027015025A patent/KR100852965B1/ko not_active IP Right Cessation
- 2001-05-08 AT AT01975152T patent/ATE417614T1/de not_active IP Right Cessation
-
2002
- 2002-11-08 NO NO20025373A patent/NO326341B1/no not_active IP Right Cessation
- 2002-12-06 ZA ZA200209917A patent/ZA200209917B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200209917B (en) | 2004-04-28 |
JP2004510701A (ja) | 2004-04-08 |
JP5101781B2 (ja) | 2012-12-19 |
EP1282609A2 (en) | 2003-02-12 |
RU2269520C2 (ru) | 2006-02-10 |
CN1441789A (zh) | 2003-09-10 |
CN100522949C (zh) | 2009-08-05 |
EP1282609A4 (en) | 2003-06-04 |
DE60137037D1 (de) | 2009-01-29 |
US20020028819A1 (en) | 2002-03-07 |
KR20030005336A (ko) | 2003-01-17 |
HUP0302358A2 (hu) | 2003-11-28 |
CZ20023693A3 (cs) | 2003-05-14 |
EP1282609B1 (en) | 2008-12-17 |
US6635649B2 (en) | 2003-10-21 |
WO2001095858A3 (en) | 2002-03-21 |
NO20025373L (no) | 2002-12-13 |
CZ301743B6 (cs) | 2010-06-09 |
NO20025373D0 (no) | 2002-11-08 |
HUP0302358A3 (en) | 2007-09-28 |
WO2001095858A2 (en) | 2001-12-20 |
NO326341B1 (no) | 2008-11-10 |
ATE417614T1 (de) | 2009-01-15 |
KR100852965B1 (ko) | 2008-08-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: CHE-MING TENG (TW) , HUI-PO WANG (TW) , ANGIORX CO Free format text: TRANSFERIDO DE: ADPHARMA, INC. |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |