ZA200209917B - Piperazinedione compounds. - Google Patents
Piperazinedione compounds. Download PDFInfo
- Publication number
- ZA200209917B ZA200209917B ZA200209917A ZA200209917A ZA200209917B ZA 200209917 B ZA200209917 B ZA 200209917B ZA 200209917 A ZA200209917 A ZA 200209917A ZA 200209917 A ZA200209917 A ZA 200209917A ZA 200209917 B ZA200209917 B ZA 200209917B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- dione
- piperazinedione
- methylidene
- piperazine
- Prior art date
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- JTHRRMFZHSDGNJ-UHFFFAOYSA-N piperazine-2,3-dione Chemical class O=C1NCCNC1=O JTHRRMFZHSDGNJ-UHFFFAOYSA-N 0.000 title description 28
- 150000001875 compounds Chemical class 0.000 claims description 60
- 125000003118 aryl group Chemical group 0.000 claims description 40
- 125000001072 heteroaryl group Chemical group 0.000 claims description 22
- 125000000623 heterocyclic group Chemical group 0.000 claims description 14
- 125000004076 pyridyl group Chemical group 0.000 claims description 14
- 125000004122 cyclic group Chemical group 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 9
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 48
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 36
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 36
- -1 PIPERAZINEDIONE COMPOUNDS Chemical class 0.000 description 34
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 32
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Saccharide Compounds (AREA)
- Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
Applications Claiming Priority (1)
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|---|---|---|---|
| US30419100P | 2000-05-09 | 2000-05-09 |
Publications (1)
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|---|---|
| ZA200209917B true ZA200209917B (en) | 2004-04-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200209917A ZA200209917B (en) | 2000-05-09 | 2002-12-06 | Piperazinedione compounds. |
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|---|---|
| US (1) | US6635649B2 (pt) |
| EP (1) | EP1282609B1 (pt) |
| JP (1) | JP5101781B2 (pt) |
| KR (1) | KR100852965B1 (pt) |
| CN (1) | CN100522949C (pt) |
| AT (1) | ATE417614T1 (pt) |
| BR (1) | BR0110745A (pt) |
| CZ (1) | CZ301743B6 (pt) |
| DE (1) | DE60137037D1 (pt) |
| HU (1) | HUP0302358A3 (pt) |
| NO (1) | NO326341B1 (pt) |
| RU (1) | RU2269520C2 (pt) |
| WO (1) | WO2001095858A2 (pt) |
| ZA (1) | ZA200209917B (pt) |
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| US7288545B2 (en) * | 2000-05-09 | 2007-10-30 | Angiorx Corporation | Piperazinedione compounds |
| JP5048201B2 (ja) | 2000-08-04 | 2012-10-17 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | ジケトピペラジン類の使用方法とジケトピペラジン類を含む組成物 |
| US7935704B2 (en) * | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| JP4674317B2 (ja) * | 2002-10-02 | 2011-04-20 | ディエムアイ アクイジション コーポレイション | 疾病の判定および監視 |
| EP2517721A3 (en) | 2003-05-15 | 2013-04-10 | DMI Biosciences, Inc. | Treatment of T-cell mediated diseases |
| AU2004275821A1 (en) * | 2003-09-25 | 2005-04-07 | Dmi Biosciences Inc. | Methods and products which utilize N-acyl-L-aspartic acid |
| NZ548659A (en) * | 2004-02-04 | 2011-01-28 | Nereus Pharmaceuticals Inc | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| US8129527B2 (en) * | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| US8217047B2 (en) * | 2008-05-27 | 2012-07-10 | Dmi Acquisition Corp. | Therapeutic methods and compounds |
| BRPI0917818A2 (pt) * | 2008-08-22 | 2017-02-21 | British Columbia Cancer Agency Branch | composto, método para modular a atividade de ar, uso de composto, composição farmacêutica, e, para preparar um composto |
| CN102395581A (zh) * | 2009-04-16 | 2012-03-28 | 泰立克公司 | 作为微管蛋白聚合抑制剂的取代的4-氨基-5-苯甲酰基-2-(苯基氨基)噻吩-3-腈和取代的4-氨基-5-苯甲酰基-2-(苯基氨基)噻吩-3-羧酰胺 |
| EP2613786A4 (en) | 2010-09-07 | 2013-10-23 | Dmi Acquisition Corp | TREATMENT OF DISEASES |
| US8710062B2 (en) * | 2011-03-11 | 2014-04-29 | Taipei Medical University | Piperazinedione compounds |
| MX2014003856A (es) | 2011-10-10 | 2015-01-16 | Ampio Pharmaceuticals Inc | Dispositivos medicos implantables con tolerancia inmune incrementada y metodos para hacerlos e implantarlos. |
| EP3721884A1 (en) | 2011-10-10 | 2020-10-14 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease with da-dkp (= aspartyl-alanyl diketopiperazine) |
| EP2771007B1 (en) | 2011-10-28 | 2018-04-04 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
| US9808454B2 (en) | 2013-03-15 | 2017-11-07 | Ampio Pharmaceuticals, Inc. | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
| JP6311097B2 (ja) * | 2013-07-31 | 2018-04-18 | 学校法人東京薬科大学 | 微小管脱重合剤 |
| KR20170045274A (ko) | 2014-08-18 | 2017-04-26 | 앰피오 파마슈티컬스 인코퍼레이티드 | 관절 징후의 치료 |
| CN104356077B (zh) * | 2014-09-11 | 2016-09-14 | 中国科学院南海海洋研究所 | 一类不对称酰基保护的2,5-二酮哌嗪衍生物及其制备方法和应用 |
| MX2017011375A (es) | 2015-03-06 | 2018-01-23 | Beyondspring Pharmaceuticals Inc | Método para tratar un tumor cerebral. |
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| WO2016209969A1 (en) | 2015-06-22 | 2016-12-29 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
| EP4011878A1 (en) | 2015-07-13 | 2022-06-15 | Beyondspring Pharmaceuticals, Inc. | Plinabulin compositions |
| CA3013467A1 (en) | 2016-02-08 | 2017-08-17 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
| KR20230018545A (ko) | 2016-06-06 | 2023-02-07 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 호중구감소증을 줄이는 조성물 및 방법 |
| JP2020503363A (ja) | 2017-01-06 | 2020-01-30 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | チューブリン結合化合物およびその治療的使用 |
| KR20190109479A (ko) | 2017-02-01 | 2019-09-25 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 호중구감소증의 감소 방법 |
| JP7350015B2 (ja) | 2018-01-24 | 2023-09-25 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | プリナブリンの投与による血小板減少症を軽減するための組成物および方法 |
| CN109580801B (zh) * | 2018-06-26 | 2021-09-07 | 深圳海王医药科技研究院有限公司 | 一种检测微管蛋白抑制剂及相关杂质的高效液相色谱法 |
| CN112010930B (zh) * | 2019-05-28 | 2022-08-02 | 首都医科大学 | Rgd修饰的五环哌嗪二酮及其制备和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5973574A (ja) * | 1982-10-21 | 1984-04-25 | Grelan Pharmaceut Co Ltd | 環状ジペプチド類 |
| GB8609908D0 (en) * | 1986-04-23 | 1986-05-29 | Fujisawa Pharmaceutical Co | Piperazine compound |
| US4806538A (en) * | 1984-11-02 | 1989-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine compound as PAF-antagonist |
| DK181687A (da) * | 1986-04-23 | 1987-10-24 | Fujisawa Pharmaceutical Co | Piperazinderivater og fremgangsmaade til fremstiling deraf |
| GB9217331D0 (en) * | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
| IL112627A0 (en) * | 1994-02-14 | 1995-05-26 | Xenova Ltd | Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them |
| GB9402807D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| JP3795093B2 (ja) * | 1994-11-25 | 2006-07-12 | キッセイ薬品工業株式会社 | １−ヒドロキシインドール誘導体 |
| JP3131574B2 (ja) * | 1996-09-04 | 2001-02-05 | 新日本製鐵株式会社 | 新規抗腫瘍物質、該物質を製造するための微生物及び方法、並びに該物質を有効成分とする細胞周期阻害剤及び抗腫瘍剤 |
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2001
- 2001-05-08 CZ CZ20023693A patent/CZ301743B6/cs not_active IP Right Cessation
- 2001-05-08 RU RU2002132897/04A patent/RU2269520C2/ru not_active IP Right Cessation
- 2001-05-08 JP JP2002510040A patent/JP5101781B2/ja not_active Expired - Fee Related
- 2001-05-08 DE DE60137037T patent/DE60137037D1/de not_active Expired - Lifetime
- 2001-05-08 BR BR0110745-3A patent/BR0110745A/pt not_active Application Discontinuation
- 2001-05-08 HU HU0302358A patent/HUP0302358A3/hu unknown
- 2001-05-08 CN CNB018125212A patent/CN100522949C/zh not_active Expired - Fee Related
- 2001-05-08 US US09/851,077 patent/US6635649B2/en not_active Expired - Fee Related
- 2001-05-08 AT AT01975152T patent/ATE417614T1/de not_active IP Right Cessation
- 2001-05-08 WO PCT/US2001/014721 patent/WO2001095858A2/en active IP Right Grant
- 2001-05-08 EP EP01975152A patent/EP1282609B1/en not_active Expired - Lifetime
- 2001-05-08 KR KR1020027015025A patent/KR100852965B1/ko not_active IP Right Cessation
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2002
- 2002-11-08 NO NO20025373A patent/NO326341B1/no not_active IP Right Cessation
- 2002-12-06 ZA ZA200209917A patent/ZA200209917B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20020028819A1 (en) | 2002-03-07 |
| EP1282609A2 (en) | 2003-02-12 |
| JP5101781B2 (ja) | 2012-12-19 |
| EP1282609A4 (en) | 2003-06-04 |
| JP2004510701A (ja) | 2004-04-08 |
| WO2001095858A2 (en) | 2001-12-20 |
| RU2269520C2 (ru) | 2006-02-10 |
| EP1282609B1 (en) | 2008-12-17 |
| CN100522949C (zh) | 2009-08-05 |
| HUP0302358A2 (hu) | 2003-11-28 |
| NO326341B1 (no) | 2008-11-10 |
| BR0110745A (pt) | 2003-12-30 |
| HUP0302358A3 (en) | 2007-09-28 |
| DE60137037D1 (de) | 2009-01-29 |
| NO20025373D0 (no) | 2002-11-08 |
| CZ20023693A3 (cs) | 2003-05-14 |
| KR20030005336A (ko) | 2003-01-17 |
| KR100852965B1 (ko) | 2008-08-19 |
| WO2001095858A3 (en) | 2002-03-21 |
| CZ301743B6 (cs) | 2010-06-09 |
| NO20025373L (no) | 2002-12-13 |
| CN1441789A (zh) | 2003-09-10 |
| ATE417614T1 (de) | 2009-01-15 |
| US6635649B2 (en) | 2003-10-21 |
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