CN1103320C - 一种用于生物活性试剂控制释放的释放体系,含有它的药物制品及其应用 - Google Patents
一种用于生物活性试剂控制释放的释放体系,含有它的药物制品及其应用 Download PDFInfo
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- CN1103320C CN1103320C CN97195027A CN97195027A CN1103320C CN 1103320 C CN1103320 C CN 1103320C CN 97195027 A CN97195027 A CN 97195027A CN 97195027 A CN97195027 A CN 97195027A CN 1103320 C CN1103320 C CN 1103320C
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- silica
- xerogel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0031—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B33/00—Silicon; Compounds thereof
- C01B33/113—Silicon oxides; Hydrates thereof
- C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
- C01B33/16—Preparation of silica xerogels
- C01B33/163—Preparation of silica xerogels by hydrolysis of organosilicon compounds, e.g. ethyl orthosilicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/43—Hormones, e.g. dexamethasone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Surgery (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Ceramic Engineering (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Silicon Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Abstract
Description
样品 | 总的孔体积(ml/g) | 孔的表面积(m2/g) | 平均孔尺寸(nm) | 中间孔尺寸(nm) |
PEG 4,600120℃(n=1) | 0.050 | 16.47 | 12.2 | 11.8 |
无PEG120℃(n=2) | 0.069(0.001) | 20.01(2.025) | 12.3(0.5) | 12.0(0.8) |
PEG 10,000120℃(n=2) | 0.042(0.001) | 13.65(0.43) | 12.4(0.2) | 12.0(0.5) |
PEG 4,60040℃(n=2) | 0.021(0.001) | 5.84(0.80) | 14.5(1.1) | 15.6(1.3) |
无PEG40℃(n=2) | 0.040(0.007) | 12.51(3.01) | 12.9(1.1) | 12.3(1.4) |
PEG 10,00040℃(n=2) | 0.038(0.005) | 10.92(0.075) | 13.9(0.7) | 13.2(0.9) |
托瑞米芬柠檬酸盐 | 熟化65小时(PH2) | 未熟化(PH2) |
斜率(%/h1/2) | 9.79 | 12.2 |
相关系数 | 0.9713 | 0.9888 |
30小时后释放的托瑞米芬柠檬酸盐 | 63.1 | 75.2 |
氧化硅 | ||
斜率(μg/h1/2) | 928.22 | 1047.47 |
相关系数 | 0.9826 | 0.9898 |
H2O/TEOS=14∶1 | PEG 4600 | PEG 10000 | 无PEG |
斜率%/mg埋植物/h | 0.052 | 0.061 | 0.085 |
相关系数 | 0.9895 | 0.9902 | 0.9903 |
H2O/TEOS=6∶1 | |||
斜率 | 0.094%/mg.h | 0.922%/mg 埋植物/h1/2 | 0.657%/mg 埋植物/h1/2 |
相关系数 | 0.9773 | 0.9915 | 0.9909 |
H2O/TEOS=14∶1 | PEG 4600 | PEG 10000 | 无PEG |
斜率%/mg 埋植物/h | 0.097 | 0.168 | 0.176 |
相关系数 | 0.9933 | 0.9896 | 0.9902 |
H2O/TEOS=6∶1 | |||
斜率%/mg 埋植物/h | 0.188 | 0.221 | 0.181 |
相关系数 | 0.9896 | 0.9770 | 0.9743 |
熟化,天 | 相对湿度11.4% | 相对湿度48.4% | 相对湿度74.7% |
0 | r=0.9808b=0.46%/mg 埋植物/h1/2 | r=0.9924b=0.53 | r=0.9728b=0.46 |
7 | r=0.9869b=0.59 | r=0.9866b=0.52 | r=0.9943b=0.66%/mg 埋植物/h |
28 | r=0.9974b=0.67 | r=0.9917b=0.74 | - |
熟化,天 | 相对湿度11.4% | 相对湿度48.4% | 相对湿度74.7% |
0%/mg 埋植物/h | r=0.9872b=0.17 | r=0.9887b=0.16 | r=0.9729b=0.2 |
7 | r=0.9857b=0.17 | r=0.9907b=0.17 | r=0.9768b=0.18 |
28 | r=0.9898b=0.16 | r=0.9840b=0.17 | - |
Claims (12)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1857596P | 1996-05-29 | 1996-05-29 | |
US60/018,575 | 1996-05-29 | ||
US4242397P | 1997-03-27 | 1997-03-27 | |
US60/042,423 | 1997-03-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1219919A CN1219919A (zh) | 1999-06-16 |
CN1103320C true CN1103320C (zh) | 2003-03-19 |
Family
ID=26691266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN97195027A Expired - Lifetime CN1103320C (zh) | 1996-05-29 | 1997-05-29 | 一种用于生物活性试剂控制释放的释放体系,含有它的药物制品及其应用 |
Country Status (18)
Country | Link |
---|---|
EP (2) | EP0906243B2 (zh) |
JP (1) | JP4322315B2 (zh) |
CN (1) | CN1103320C (zh) |
AT (1) | ATE301102T1 (zh) |
AU (1) | AU738176B2 (zh) |
CA (1) | CA2257172C (zh) |
CZ (1) | CZ297042B6 (zh) |
DE (1) | DE69733889T3 (zh) |
DK (1) | DK0906243T4 (zh) |
EE (1) | EE03758B1 (zh) |
ES (1) | ES2244998T5 (zh) |
HU (1) | HU227939B1 (zh) |
NO (1) | NO328711B1 (zh) |
NZ (1) | NZ332968A (zh) |
PL (1) | PL330191A1 (zh) |
RU (1) | RU2208582C2 (zh) |
SK (1) | SK284193B6 (zh) |
WO (1) | WO1997045367A1 (zh) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
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FI980032A0 (fi) * | 1998-01-09 | 1998-01-09 | Heikki Matti Eemeli Rauvala | Ny anvaendning av en heparin bindande, med tillvaext foerknippad molekyl |
FI109332B (fi) * | 1998-12-17 | 2002-07-15 | Orion Yhtymae Oyj | Toremifeenin liukoisia koostumuksia |
US6395299B1 (en) | 1999-02-12 | 2002-05-28 | Biostream, Inc. | Matrices for drug delivery and methods for making and using the same |
CZ20012748A3 (cs) * | 1999-02-22 | 2002-03-13 | Bioxid Oy | Způsob výroby řízeně biodegradovatelných keramických vláken z hydrosolu kysličníku křemičitého |
FI19991806A (fi) * | 1999-08-25 | 2001-02-26 | Yli Urpo Antti | Uusia koostumuksia biologisesti aktiivisen aineen säädettyyn vapauttamiseen, ja niiden valmistus |
US6632412B2 (en) * | 1999-12-01 | 2003-10-14 | Timo Peltola | Bioactive sol-gel derived silica fibers and methods for their preparation |
AUPQ573300A0 (en) * | 2000-02-21 | 2000-03-16 | Australian Nuclear Science & Technology Organisation | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use |
US7758888B2 (en) | 2000-04-21 | 2010-07-20 | Sol-Gel Technologies Ltd. | Composition exhibiting enhanced formulation stability and delivery of topical active ingredients |
EP1335693A2 (en) | 2000-04-21 | 2003-08-20 | Sol-Gel Technologies Ltd. | Composition exhibiting enhanced formulation stability and delivery of topical active ingredients |
WO2002080977A1 (en) * | 2001-04-04 | 2002-10-17 | Delsitech Oy | Biodegradable carrier and method for preparation thereof |
JP4199545B2 (ja) * | 2001-04-27 | 2008-12-17 | ビボキシド オサケユイチア | 軟組織付着の改善方法、および移植片作製のための該方法の使用 |
WO2005007802A2 (en) * | 2002-03-15 | 2005-01-27 | The Trustees Of The University Of Pennsylvania | Fibrous composite for tissue engineering |
EP1675570B1 (en) * | 2003-01-24 | 2016-12-14 | The Research Foundation Of State University Of New York | Use of photodynamic therapeutic agents entrapped in ceramic nanoparticles |
EP1656199B1 (en) | 2003-07-31 | 2016-01-06 | Sol-Gel Technologies Ltd. | Microcapsules loaded with active ingredients and a method for their preparation |
KR20070001145A (ko) | 2004-02-27 | 2007-01-03 | 델시테크 오와이 | 조정가능한 생체 재흡수성의 졸-겔 유도 이산화규소를제조하기 위한 방법 |
GB0420016D0 (en) | 2004-09-09 | 2004-10-13 | Leuven K U Res & Dev | Controlled release oral delivery system |
JP4006002B2 (ja) * | 2004-11-26 | 2007-11-14 | キヤノン株式会社 | Dna担持繊維及びdna担持繊維シート並びにこれらの製造方法 |
EP2431088A1 (en) | 2005-08-02 | 2012-03-21 | Sol-Gel Technologies Ltd. | Metal oxide coating of water insoluble ingredients |
EP1942731A2 (en) | 2005-09-27 | 2008-07-16 | Sol-Gel Technologies Ltd. | Methods for crop protection |
US8450105B2 (en) | 2006-05-04 | 2013-05-28 | Agency For Science, Technology And Research | Mechanically reversible gel |
EP2020987B1 (en) * | 2006-06-06 | 2013-10-30 | Universidad Autónoma Metropolitana | Sol-gel nanostructured titania reservoirs for use in the controlled release of drugs in the central nervous system and method of synthesis |
JP2010505883A (ja) | 2006-10-12 | 2010-02-25 | ザ ユニバーシティー オブ クイーンズランド | 免疫応答を調節するための組成物および方法 |
DE102007061873A1 (de) * | 2007-01-15 | 2008-07-17 | Bayer Innovation Gmbh | Kieselsol-Material zur Herstellung von biologisch degradierbaren und/oder resorbierbaren Kieselgel-Materialien dessen Herstellung und Verwendung |
FI20070174A0 (fi) * | 2007-02-28 | 2007-02-28 | Delsitech Oy | Menetelmä silikakoostumusten valmistamiseksi, silikakoostumukset ja niiden käytöt |
JP5344417B2 (ja) * | 2007-04-17 | 2013-11-20 | 国立大学法人群馬大学 | 水油界面を利用した薬物−シリカ封入体の製造法 |
DE102007026043B4 (de) * | 2007-06-04 | 2018-08-16 | Jiangsu Synecoun Medical Technology Co., Ltd. | Nicht-toxisches Polyethoxysiloxan-Material zur Herstellung von biologisch resorbierbares und/oder bioaktives Polyethoxysiloxan-Material enthaltenden Artikeln, dessen Herstellung und Verwendung |
DE102007061874A1 (de) * | 2007-12-19 | 2009-06-25 | Bayer Innovation Gmbh | Nicht-toxisches Polysiloxan-Material zur Herstellung von biologisch resorbierbaren und/oder bioaktiven Polysiloxan-Material enthaltenden Artikeln, dessen Herstellung und Verwendung |
DE102008033327A1 (de) * | 2008-07-16 | 2010-01-21 | Bayer Innovation Gmbh | Kieselsol-Material mit mindestens einem therapeutisch aktiven Wirkstoff zur Herstellung von biologisch degradierbaren und/oder resorbierbaren Kieselgel-Materialien für die Humanmedizin und/oder Medizintechnik |
DE102009053782A1 (de) * | 2009-11-19 | 2011-06-01 | BSH Bosch und Siemens Hausgeräte GmbH | Poröses SiO2-Xerogel mit charakteristischer Porengröße, dessen trocknungsstabile Vorstufen und dessen Anwendung |
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