CN110317214B - 作为蛋白质激酶的调节剂的二芳基巨环 - Google Patents
作为蛋白质激酶的调节剂的二芳基巨环 Download PDFInfo
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- CN110317214B CN110317214B CN201910549748.XA CN201910549748A CN110317214B CN 110317214 B CN110317214 B CN 110317214B CN 201910549748 A CN201910549748 A CN 201910549748A CN 110317214 B CN110317214 B CN 110317214B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Diabetes (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461931506P | 2014-01-24 | 2014-01-24 | |
| US61/931,506 | 2014-01-24 | ||
| US201462049326P | 2014-09-11 | 2014-09-11 | |
| US62/049,326 | 2014-09-11 | ||
| US201562106301P | 2015-01-22 | 2015-01-22 | |
| US62/106,301 | 2015-01-22 | ||
| CN201580005705.5A CN106170289B (zh) | 2014-01-24 | 2015-01-23 | 作为蛋白质激酶的调节剂的二芳基巨环 |
| PCT/US2015/012597 WO2015112806A2 (en) | 2014-01-24 | 2015-01-23 | Diaryl macrocycles as modulators of protein kinases |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580005705.5A Division CN106170289B (zh) | 2014-01-24 | 2015-01-23 | 作为蛋白质激酶的调节剂的二芳基巨环 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110317214A CN110317214A (zh) | 2019-10-11 |
| CN110317214B true CN110317214B (zh) | 2022-11-22 |
Family
ID=53682127
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910549014.1A Active CN110317213B (zh) | 2014-01-24 | 2015-01-23 | 作为蛋白质激酶的调节剂的二芳基巨环 |
| CN201580005705.5A Active CN106170289B (zh) | 2014-01-24 | 2015-01-23 | 作为蛋白质激酶的调节剂的二芳基巨环 |
| CN201910549748.XA Active CN110317214B (zh) | 2014-01-24 | 2015-01-23 | 作为蛋白质激酶的调节剂的二芳基巨环 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910549014.1A Active CN110317213B (zh) | 2014-01-24 | 2015-01-23 | 作为蛋白质激酶的调节剂的二芳基巨环 |
| CN201580005705.5A Active CN106170289B (zh) | 2014-01-24 | 2015-01-23 | 作为蛋白质激酶的调节剂的二芳基巨环 |
Country Status (35)
Families Citing this family (94)
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| CN102971322A (zh) * | 2010-05-20 | 2013-03-13 | 阵列生物制药公司 | 作为trk激酶抑制剂的大环化合物 |
| WO2012136859A1 (en) * | 2011-04-07 | 2012-10-11 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for liver regeneration and for treatment of liver failure |
| WO2013028465A1 (en) * | 2011-08-19 | 2013-02-28 | Merck Sharp & Dohme Corp. | Crystal forms of a hcv protease inhibitor |
| CN104470523A (zh) * | 2012-03-09 | 2015-03-25 | 莱西肯医药有限公司 | 基于咪唑并[1,2-b]哒嗪的化合物、包含它们的组合物及其使用方法 |
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