MX2022013838A - Compuestos heterociclicos como agonistas del receptor de activacion expresado en las celulas mieloides 2 y metodos de uso. - Google Patents
Compuestos heterociclicos como agonistas del receptor de activacion expresado en las celulas mieloides 2 y metodos de uso.Info
- Publication number
- MX2022013838A MX2022013838A MX2022013838A MX2022013838A MX2022013838A MX 2022013838 A MX2022013838 A MX 2022013838A MX 2022013838 A MX2022013838 A MX 2022013838A MX 2022013838 A MX2022013838 A MX 2022013838A MX 2022013838 A MX2022013838 A MX 2022013838A
- Authority
- MX
- Mexico
- Prior art keywords
- myeloid cells
- receptor expressed
- agonists
- methods
- compounds
- Prior art date
Links
- 102100029678 Triggering receptor expressed on myeloid cells 2 Human genes 0.000 title abstract 3
- 101710174937 Triggering receptor expressed on myeloid cells 2 Proteins 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 101000795117 Homo sapiens Triggering receptor expressed on myeloid cells 2 Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente descripción proporciona compuestos de la Fórmula I, útiles para la activación del receptor de activación expresado en células mieloides 2 ("TREM2"). (ver formula) I la presente descripción también proporciona composiciones farmacéuticas que comprenden los compuestos, usos de los compuestos, y composiciones para el tratamiento, por ejemplo, de un trastorno neurodegenerativo. además, la descripción proporciona productos intermedios útiles en la síntesis de compuestos de la Fórmula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063019768P | 2020-05-04 | 2020-05-04 | |
PCT/US2021/030719 WO2021226135A1 (en) | 2020-05-04 | 2021-05-04 | Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022013838A true MX2022013838A (es) | 2023-02-22 |
Family
ID=78468393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022013838A MX2022013838A (es) | 2020-05-04 | 2021-05-04 | Compuestos heterociclicos como agonistas del receptor de activacion expresado en las celulas mieloides 2 y metodos de uso. |
Country Status (17)
Country | Link |
---|---|
US (3) | US20240190863A1 (es) |
EP (1) | EP4146220A4 (es) |
JP (1) | JP2023524806A (es) |
KR (1) | KR20230020983A (es) |
CN (1) | CN116322696A (es) |
AU (1) | AU2021267161A1 (es) |
BR (1) | BR112022022338A2 (es) |
CA (1) | CA3182541A1 (es) |
CL (1) | CL2022003041A1 (es) |
CO (1) | CO2022015927A2 (es) |
CR (1) | CR20220559A (es) |
CU (1) | CU20220065A7 (es) |
EC (1) | ECSP22089520A (es) |
IL (1) | IL297845A (es) |
MX (1) | MX2022013838A (es) |
PE (1) | PE20230609A1 (es) |
WO (1) | WO2021226135A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112022022338A2 (pt) * | 2020-05-04 | 2023-01-10 | Amgen Inc | Compostos heterocíclicos como receptor desencadeador expresso em agonistas de células mieloides 2 e métodos de uso |
TW202334141A (zh) * | 2021-11-09 | 2023-09-01 | 美商維佳神經科學有限公司 | 作為骨髓細胞上表現之觸發受體2促效劑之雜環化合物及其使用方法 |
WO2023086801A1 (en) * | 2021-11-09 | 2023-05-19 | Vigil Neuroscience, Inc. | Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use |
WO2024008722A2 (en) * | 2022-07-04 | 2024-01-11 | Muna Therapeutics Aps | Trem2 modulators |
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2021
- 2021-05-04 BR BR112022022338A patent/BR112022022338A2/pt unknown
- 2021-05-04 MX MX2022013838A patent/MX2022013838A/es unknown
- 2021-05-04 CN CN202180045770.6A patent/CN116322696A/zh active Pending
- 2021-05-04 CU CU2022000065A patent/CU20220065A7/es unknown
- 2021-05-04 AU AU2021267161A patent/AU2021267161A1/en active Pending
- 2021-05-04 KR KR1020227042514A patent/KR20230020983A/ko active Search and Examination
- 2021-05-04 JP JP2022567488A patent/JP2023524806A/ja active Pending
- 2021-05-04 EP EP21799590.1A patent/EP4146220A4/en active Pending
- 2021-05-04 US US17/923,160 patent/US20240190863A1/en active Pending
- 2021-05-04 CR CR20220559A patent/CR20220559A/es unknown
- 2021-05-04 CA CA3182541A patent/CA3182541A1/en active Pending
- 2021-05-04 IL IL297845A patent/IL297845A/en unknown
- 2021-05-04 PE PE2022002572A patent/PE20230609A1/es unknown
- 2021-05-04 WO PCT/US2021/030719 patent/WO2021226135A1/en active Application Filing
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2022
- 2022-11-03 CL CL2022003041A patent/CL2022003041A1/es unknown
- 2022-11-04 CO CONC2022/0015927A patent/CO2022015927A2/es unknown
- 2022-11-21 EC ECSENADI202289520A patent/ECSP22089520A/es unknown
- 2022-11-30 US US18/072,497 patent/US11718617B2/en active Active
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2023
- 2023-04-28 US US18/309,281 patent/US20240124446A1/en active Pending
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PE20230609A1 (es) | 2023-04-13 |
JP2023524806A (ja) | 2023-06-13 |
EP4146220A1 (en) | 2023-03-15 |
KR20230020983A (ko) | 2023-02-13 |
CR20220559A (es) | 2023-08-18 |
CU20220065A7 (es) | 2023-06-13 |
CA3182541A1 (en) | 2021-11-11 |
US20240190863A1 (en) | 2024-06-13 |
US11718617B2 (en) | 2023-08-08 |
CN116322696A (zh) | 2023-06-23 |
IL297845A (en) | 2023-01-01 |
CL2022003041A1 (es) | 2023-07-14 |
EP4146220A4 (en) | 2024-05-29 |
BR112022022338A2 (pt) | 2023-01-10 |
US20230144581A1 (en) | 2023-05-11 |
WO2021226135A1 (en) | 2021-11-11 |
CO2022015927A2 (es) | 2023-01-26 |
ECSP22089520A (es) | 2023-02-28 |
US20240124446A1 (en) | 2024-04-18 |
AU2021267161A1 (en) | 2022-12-08 |
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