CL2022003041A1 - Compuestos heterocíclicos como agonistas del receptor de activación expresado en las células mieloides 2 - Google Patents

Compuestos heterocíclicos como agonistas del receptor de activación expresado en las células mieloides 2

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Publication number
CL2022003041A1
CL2022003041A1 CL2022003041A CL2022003041A CL2022003041A1 CL 2022003041 A1 CL2022003041 A1 CL 2022003041A1 CL 2022003041 A CL2022003041 A CL 2022003041A CL 2022003041 A CL2022003041 A CL 2022003041A CL 2022003041 A1 CL2022003041 A1 CL 2022003041A1
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CL
Chile
Prior art keywords
agonists
compounds
heterocyclic compounds
myeloid cells
receptor expressed
Prior art date
Application number
CL2022003041A
Other languages
English (en)
Inventor
C Czabaniuk Lara
Hopper Timothy
B Houze Jonathan
Rescourio Gwenaella
Santora Vincent
Wang Haoxuan
D White Ryan
R Wong Alice
Wu Yongwei
Original Assignee
Amgen Inc
Vigil Neuroscience Inc
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Application filed by Amgen Inc, Vigil Neuroscience Inc filed Critical Amgen Inc
Publication of CL2022003041A1 publication Critical patent/CL2022003041A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente descripción proporciona compuestos de la Fórmula I, útiles para la activación del receptor de activación expresado en células mieloides 2 (TREM2). La presente descripción también proporciona composiciones farmacéuticas que comprenden los compuestos, usos de los compuestos, y composiciones para el tratamiento, por ejemplo, de un trastorno neurodegenerativo. Además, la descripción proporciona productos intermedios útiles en la síntesis de compuestos de la Fórmula I.
CL2022003041A 2020-05-04 2022-11-03 Compuestos heterocíclicos como agonistas del receptor de activación expresado en las células mieloides 2 CL2022003041A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063019768P 2020-05-04 2020-05-04

Publications (1)

Publication Number Publication Date
CL2022003041A1 true CL2022003041A1 (es) 2023-07-14

Family

ID=78468393

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2022003041A CL2022003041A1 (es) 2020-05-04 2022-11-03 Compuestos heterocíclicos como agonistas del receptor de activación expresado en las células mieloides 2

Country Status (17)

Country Link
US (3) US20240190863A1 (es)
EP (1) EP4146220A4 (es)
JP (1) JP2023524806A (es)
KR (1) KR20230020983A (es)
CN (1) CN116322696A (es)
AU (1) AU2021267161A1 (es)
BR (1) BR112022022338A2 (es)
CA (1) CA3182541A1 (es)
CL (1) CL2022003041A1 (es)
CO (1) CO2022015927A2 (es)
CR (1) CR20220559A (es)
CU (1) CU20220065A7 (es)
EC (1) ECSP22089520A (es)
IL (1) IL297845A (es)
MX (1) MX2022013838A (es)
PE (1) PE20230609A1 (es)
WO (1) WO2021226135A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230020983A (ko) * 2020-05-04 2023-02-13 암젠 인코포레이션 골수성 세포 2 작용제 상에서 발현되는 유발 수용체로서의 헤테로고리 화합물 및 사용 방법
TW202325290A (zh) * 2021-11-09 2023-07-01 美商維佳神經科學有限公司 作為骨髓細胞上表現之觸發受體2促效劑之雜環化合物及其使用方法
TW202334141A (zh) * 2021-11-09 2023-09-01 美商維佳神經科學有限公司 作為骨髓細胞上表現之觸發受體2促效劑之雜環化合物及其使用方法
WO2024008722A2 (en) * 2022-07-04 2024-01-11 Muna Therapeutics Aps Trem2 modulators

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CR20220559A (es) 2023-08-18
US20240124446A1 (en) 2024-04-18
US11718617B2 (en) 2023-08-08
JP2023524806A (ja) 2023-06-13
IL297845A (en) 2023-01-01
CO2022015927A2 (es) 2023-01-26
BR112022022338A2 (pt) 2023-01-10
CA3182541A1 (en) 2021-11-11
CN116322696A (zh) 2023-06-23
PE20230609A1 (es) 2023-04-13
AU2021267161A1 (en) 2022-12-08
MX2022013838A (es) 2023-02-22
KR20230020983A (ko) 2023-02-13
US20230144581A1 (en) 2023-05-11
WO2021226135A1 (en) 2021-11-11
CU20220065A7 (es) 2023-06-13
US20240190863A1 (en) 2024-06-13
EP4146220A4 (en) 2024-05-29
EP4146220A1 (en) 2023-03-15

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