CN109789105B - 通过盐至中性药物原位转化的组合物、透皮贴剂及应用 - Google Patents

通过盐至中性药物原位转化的组合物、透皮贴剂及应用 Download PDF

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CN109789105B
CN109789105B CN201780059417.7A CN201780059417A CN109789105B CN 109789105 B CN109789105 B CN 109789105B CN 201780059417 A CN201780059417 A CN 201780059417A CN 109789105 B CN109789105 B CN 109789105B
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weight
active agent
composition
drug
salt
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CN109789105A (zh
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E·S·李
A·K·简恩
P·辛格
A·萨基
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Corian Co ltd
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Corian Co
Corium International Inc
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CN201780059417.7A 2016-07-27 2017-07-26 通过盐至中性药物原位转化的组合物、透皮贴剂及应用 Active CN109789105B (zh)

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CN202211676624.6A CN116270551A (zh) 2016-07-27 2017-07-26 通过盐至中性药物原位转化的组合物、透皮贴剂及应用

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US201662367502P 2016-07-27 2016-07-27
US201662367542P 2016-07-27 2016-07-27
US62/367,542 2016-07-27
US62/367,502 2016-07-27
US201662423133P 2016-11-16 2016-11-16
US62/423,133 2016-11-16
US201762444745P 2017-01-10 2017-01-10
US201762444763P 2017-01-10 2017-01-10
US62/444,763 2017-01-10
US62/444,745 2017-01-10
US201762457794P 2017-02-10 2017-02-10
US62/457,794 2017-02-10
US201762504391P 2017-05-10 2017-05-10
US201762504408P 2017-05-10 2017-05-10
US62/504,391 2017-05-10
US62/504,408 2017-05-10
PCT/US2017/044048 WO2018022815A2 (en) 2016-07-27 2017-07-26 Transdermal formulation and delivery method of low solubility or unstable unionized neutral drugs by in situ salt-to-neutral drug conversion of salt drug

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CN202211676624.6A Pending CN116270551A (zh) 2016-07-27 2017-07-26 通过盐至中性药物原位转化的组合物、透皮贴剂及应用
CN201780059417.7A Active CN109789105B (zh) 2016-07-27 2017-07-26 通过盐至中性药物原位转化的组合物、透皮贴剂及应用
CN202310658352.5A Pending CN116966166A (zh) 2016-07-27 2017-07-26 碳酸氢钠原位转化驱动胺药物的透皮递送
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CN202211676624.6A Pending CN116270551A (zh) 2016-07-27 2017-07-26 通过盐至中性药物原位转化的组合物、透皮贴剂及应用

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CN201780059393.5A Pending CN109789133A (zh) 2016-07-27 2017-07-26 多奈哌齐透皮递送系统

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AU (7) AU2017302306A1 (enExample)
CA (2) CA3031945C (enExample)
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* Cited by examiner, † Cited by third party
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KR20170110083A (ko) 2014-12-23 2017-10-10 인털렉츄얼 프라퍼티 어쏘시에이츠, 엘엘씨 경피 투여를 위한 방법 및 제형
BR112018010101A2 (pt) * 2015-11-18 2018-11-13 Commonwealth Scientific And Industrial Research Organisation grão de arroz com aleurona espessada
SG11201805570WA (en) 2015-12-30 2018-07-30 Corium Int Inc Systems and methods for long term transdermal administration
WO2017223402A1 (en) 2016-06-23 2017-12-28 Corium International, Inc. Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
RU2764764C2 (ru) 2016-07-27 2022-01-21 Кориум Интернэшнл, Инк. Трансдермальные системы доставки мемантина
US20180028663A1 (en) 2016-07-27 2018-02-01 Corium International, Inc. Sodium bicarbonate in situ conversion driven transdermal delivery of amine drug
CA3071007A1 (en) * 2017-07-26 2019-01-31 Corium, Inc. Transdermal delivery system with a microporous membrane having solvent-filled pores
EP3681479B1 (en) 2017-09-15 2024-01-31 Dyve Biosciences, Inc. Sodium bicarbonate for use in the treatment of gout and related disorders
CA3086163A1 (en) 2017-12-20 2019-06-27 Corium, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
KR102823139B1 (ko) * 2018-08-31 2025-06-19 에스케이케미칼 주식회사 장기 투여용 리바스티그민 패취
KR102710072B1 (ko) * 2018-08-31 2024-09-24 에스케이케미칼 주식회사 장기 투여용 리바스티그민 패취
KR102115102B1 (ko) 2018-12-21 2020-05-26 동아에스티 주식회사 안정화된 도네페질 함유 경피 흡수제제
KR102372630B1 (ko) * 2019-05-15 2022-03-14 주식회사 대웅제약 고함량의 도네페질 또는 그의 염을 포함하는 경피흡수제제
US11101101B2 (en) * 2019-05-15 2021-08-24 Fei Company Laser-based phase plate image contrast manipulation
JP7641279B2 (ja) * 2019-10-24 2025-03-06 エルテーエス ローマン テラピー-ジステーメ アーゲー フィンゴリモドの経皮投与のための経皮治療システム
US20230015492A1 (en) * 2019-11-26 2023-01-19 Hisamitsu Pharmaceutical Co., Inc. Method for improving holding power of adhesive agent layer of ropinirole-containing patch, and ropinirole-containing patch with improved holding power
WO2021127092A1 (en) * 2019-12-18 2021-06-24 Pioneer Hi-Bred International, Inc. Compositions and methods for improving grain yield in plants
CN115397402A (zh) * 2020-04-14 2022-11-25 格兰尼斯制药公司 包含羟氯喹和/或氯喹的经皮和/或局部递送系统
JP2022044038A (ja) * 2020-09-04 2022-03-16 株式会社大石膏盛堂 ドネペジル含有経皮吸収液剤およびその製造方法
CN112656778A (zh) * 2020-12-28 2021-04-16 广东红珊瑚药业有限公司 一种压敏胶基质以及一种贴剂
US12270039B2 (en) * 2021-05-14 2025-04-08 Board Of Trustees Of Southern Illinois University Compositions and methods to increase oleic acid content in soybeans
US12270040B2 (en) * 2021-05-27 2025-04-08 Board Of Trustees Of Southern Illinois University Soybean lines with low saturated fatty acid and high oleic acid contents
WO2023283103A1 (en) * 2021-07-08 2023-01-12 Monsanto Technology Llc Novel insect inhibitory proteins
WO2025103446A1 (zh) * 2023-11-16 2025-05-22 宜昌人福药业有限责任公司 含有多奈哌齐的透皮贴剂及其制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101460156A (zh) * 2006-05-08 2009-06-17 帝国制药株式会社 抗痴呆药的经皮吸收制剂
CN101568340A (zh) * 2006-12-01 2009-10-28 日东电工株式会社 经皮吸收制剂
WO2010083035A2 (en) * 2009-01-14 2010-07-22 Corium International, Inc. Transdermal administration of tamsulosin
CN101969937A (zh) * 2008-03-11 2011-02-09 Lts勒曼治疗系统股份公司 具有稳定化膜的透皮治疗系统
CN102834093A (zh) * 2009-12-16 2012-12-19 帝国制药株式会社 抗痴呆药物的经皮吸收制剂
CN103068377A (zh) * 2010-06-17 2013-04-24 Lts勒曼治疗系统股份公司 透皮施用美金刚
CN105611917A (zh) * 2013-10-11 2016-05-25 帝国制药美国公司 局部鞘氨醇-1-磷酸酯受体激动剂制剂及其使用方法
CN105693556A (zh) * 2016-03-01 2016-06-22 巴斯特医药科技(常州)有限公司 卡巴拉汀酒石酸盐的转化方法及其产物制成的贴片

Family Cites Families (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3391142A (en) 1966-02-09 1968-07-02 Lilly Co Eli Adamantyl secondary amines
NL134681C (enExample) 1966-04-26
US3546141A (en) 1966-08-08 1970-12-08 Mc Donnell Douglas Corp Phosphorus-nitrogen polymers and process
NL7305644A (enExample) 1972-04-20 1973-10-23
DE2856393C2 (de) 1978-12-27 1983-04-28 Merz + Co GmbH & Co, 6000 Frankfurt Arzneimittel zur Behandlung von Morbus Parkinson
ATE45735T1 (de) 1984-12-22 1989-09-15 Thomae Gmbh Dr K Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel.
US4880633A (en) 1986-03-12 1989-11-14 Merck & Co., Inc. Transdermal drug delivery system
US4797284A (en) * 1986-03-12 1989-01-10 Merck & Co., Inc. Transdermal drug delivery system
DE3634016A1 (de) 1986-04-17 1987-10-29 Lohmann Gmbh & Co Kg Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung
FI95572C (fi) 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
US4837027A (en) 1987-11-09 1989-06-06 Alza Corporation Transdermal drug delivery device
US4781924A (en) 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US4849224A (en) 1987-11-12 1989-07-18 Theratech Inc. Device for administering an active agent to the skin or mucosa
US5026556A (en) 1988-11-10 1991-06-25 Norwich Eaton Pharmaceuticals, Inc. Compositions for the transdermal delivery of pharmaceutical actives
CA2007181C (en) * 1989-01-06 1998-11-24 Angelo Mario Morella Sustained release pharmaceutical composition
DE58905637D1 (de) 1989-04-14 1993-10-21 Merz & Co Gmbh & Co Verwendung von Adamantan-Derivaten zur Prävention und Behandlung der cerebralen Ischämie.
DE3913734C2 (de) * 1989-04-26 1998-08-20 Roehm Gmbh Verwendung einer wäßrigen Hauthaftkleberlösung zur Herstellung einer mit Wasser leicht abwaschbaren Klebschicht
MY115126A (en) * 1990-04-27 2003-04-30 Seikisui Chemical Co Ltd Percutaneously absorbable eperisone or tolperisone preparation.
US5252588A (en) * 1990-04-27 1993-10-12 Sekisui Kagaku Kogyo Kabushiki Kaisha Percutaneously absorbable crosslinked polyvinylpyrrolidone eperisone or tolperisone preparation
AU652952B2 (en) 1990-07-23 1994-09-15 Alza Corporation Oral osmotic device for delivering nicotine
US5614560A (en) 1991-04-04 1997-03-25 Children's Medical Center Corporation Method of preventing NMDA receptor-mediated neuronal damage
US5123900A (en) 1991-08-16 1992-06-23 Bertek, Inc. Moisture permeable double disk
JPH06199659A (ja) 1992-10-28 1994-07-19 Hisamitsu Pharmaceut Co Inc 経皮治療用装置
DE4310012A1 (de) * 1993-03-27 1994-09-29 Roehm Gmbh Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung
US5424077A (en) 1993-07-13 1995-06-13 Church & Dwight Co., Inc. Co-micronized bicarbonate salt compositions
US5733900A (en) 1994-04-21 1998-03-31 Hisamitsu Pharmaceutical Co., Inc. Percutaneous administration base composition and percutaneous administration medicinal composition comprising said base composition and medicine
WO1996008229A2 (en) 1994-09-14 1996-03-21 Minnesota Mining And Manufacturing Company Matrix for transdermal drug delivery
US5635203A (en) * 1994-09-29 1997-06-03 Alza Corporation Transdermal device having decreased delamination
CN1170360A (zh) 1994-12-21 1998-01-14 瑟垃技术有限公司 具有粘性贴面和剥离密封圆片的经皮输送系统
WO1996040087A2 (en) 1995-06-07 1996-12-19 Cygnus, Inc. Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group
DE19531342B4 (de) 1995-08-25 2007-11-29 Merz Pharma Gmbh & Co. Kgaa Verwendung von Aminoadamantan-Verbindungen als Immunregulatoren
US6929801B2 (en) 1996-02-19 2005-08-16 Acrux Dds Pty Ltd Transdermal delivery of antiparkinson agents
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
US5958919A (en) 1996-09-20 1999-09-28 Washington University Treatment of presymptomatic alzheimer's disease to prevent neuronal degeneration
ATE229817T1 (de) 1996-10-24 2003-01-15 Alza Corp Penetrationsfördernde substanzen für die transdermale verabreichung von wirkstoffen, vorrichtungen und verfahren zur herstellung
CN1174031A (zh) * 1997-04-23 1998-02-25 谢先运 双氯芬酸钠透皮控释贴膏
US5866585A (en) 1997-05-22 1999-02-02 Synchroneuron, Llc Methods of treating tardive dyskinesia using NMDA receptor antagonists
US20040018241A1 (en) * 1997-09-26 2004-01-29 Noven Pharmaceuticals, Inc. Bioadhesive compositions and methods for topical administration of active agents
US6193993B1 (en) 1998-03-03 2001-02-27 Eisai Co., Ltd. Suppository containing an antidementia medicament
JP4205778B2 (ja) * 1998-04-17 2009-01-07 久光製薬株式会社 貼付製剤
DE19820999A1 (de) 1998-05-11 1999-11-18 Lohmann Therapie Syst Lts Laminat zum Aufbringen auf einen Akzeptor
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6383471B1 (en) 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6562368B2 (en) * 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers
US20020192243A1 (en) * 1999-12-16 2002-12-19 Tsung-Min Hsu Transdermal and topical administration of drugs for the treatment of Alzheimer's disease using basic enhancers
US6455066B1 (en) 2000-03-10 2002-09-24 Epicept Corporation Intradermal-penetration agents for topical local anesthetic administration
US7276249B2 (en) 2002-05-24 2007-10-02 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
CN100340237C (zh) * 2000-11-06 2007-10-03 株式会社三养社 吸水性和粘附性能改善的经皮给药系统
WO2002038139A1 (en) * 2000-11-07 2002-05-16 Hisamitsu Pharmaceutical Co., Inc. Pharmaceutical preparation of percutaneous absorption type
JP4850346B2 (ja) * 2001-03-15 2012-01-11 救急薬品工業株式会社 粘膜貼付剤
CA2445086C (en) 2001-05-01 2008-04-08 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions
NZ531785A (en) 2001-08-20 2007-03-30 Maiken Nedergaard Treatment of glial tumors with ionotropic glutamate receptor antagonists
RU2310441C9 (ru) 2001-09-04 2008-03-10 Тромсдорф ГмбХ унд Ко.КГ Арцнаймиттель Способ профилактики и/или лечения дисфункции, и/или нарушения структуры ногтей, пластырь для его осуществления и его применение
EP1437130A4 (en) * 2001-10-17 2009-08-26 Hisamitsu Pharmaceutical Co PERCUTANEOUS ABSORPTION PREPARATIONS
ITMI20012827A1 (it) * 2001-12-28 2003-06-28 Fidia Farmaceutici Formulazioni adesive transdermiche di diclofenac sodico
US7273619B2 (en) 2002-01-17 2007-09-25 Samyang Corporation Transdermal composition of an antivomiting agent
AU2003274353B2 (en) 2002-10-24 2007-04-05 Merz Pharma Gmbh & Co. Kgaa Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors
ATE534373T1 (de) 2003-10-10 2011-12-15 Antares Pharma Ipl Ag Transdermale pharmazeutische formulierung zur minimierung von rückständen auf der haut
JP2007510628A (ja) * 2003-10-14 2007-04-26 ダーマトレンズ,インコーポレイティド 親水性薬剤の経皮投与の促進
ATE411015T1 (de) 2003-10-22 2008-10-15 Merz Pharma Gmbh & Co Kgaa Verwendung von 1-aminocyclohexan-derivaten zur modifizierung der abscheidung von fibrillogenen as peptiden in amyloidpathien
US7740633B2 (en) 2003-10-23 2010-06-22 Trans1 Inc. Guide pin for guiding instrumentation along a soft tissue tract to a point on the spine
JP2007512339A (ja) 2003-11-21 2007-05-17 メモリー・ファーマシューティカルズ・コーポレイション 記憶障害の処置における(+)−イソプロピル2−メトキシエチル4−(2−クロロ−3−シアノ−フェニル)−1,4−ジヒドロ−2,6−ジメチル−ピリジン−3,5−ジカルボキシラートの使用
US7176185B2 (en) 2003-11-25 2007-02-13 Tsrl, Inc. Short peptide carrier system for cellular delivery of agent
KR20130116378A (ko) 2004-02-17 2013-10-23 트랜스셉트 파마슈티칼스, 인코포레이티드 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법
US7670838B2 (en) 2004-05-24 2010-03-02 The Board Of Trustees Of The Leland Stanford Junior University Coupling of excitation and neurogenesis in neural stem/progenitor cells
JPWO2005115355A1 (ja) 2004-05-28 2008-03-27 久光製薬株式会社 貼付製剤
TW200616608A (en) 2004-07-09 2006-06-01 Forest Laboratories Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
MX2007004315A (es) 2004-10-08 2008-03-11 Noven Pharma Dispositivo para suministro transdermico de farmaco que incluye un respaldo oclusivo.
ES2317138T3 (es) 2004-11-22 2009-04-16 Hisamitsu Pharmaceutical Co., Inc. Parche transdermico que comprende un agente de diminucion del punto de fusion.
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
US20060205822A1 (en) 2004-12-22 2006-09-14 Forest Laboratories, Inc. 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
HRP20090676T1 (hr) 2005-01-11 2010-01-31 Teva Pharmaceutical Fine Chemicals S.R.L. Postupak dobivanja 1-amino-3,5-dimetiladamantan-hidroklorida
WO2006082728A1 (ja) * 2005-02-04 2006-08-10 Hisamitsu Pharmaceutical Co., Inc. 経皮吸収貼付剤
US20060188558A1 (en) 2005-02-18 2006-08-24 Mylan Technologies, Inc. Transdermal systems having control delivery system
EP1874282B1 (en) 2005-04-06 2010-09-15 Adamas Pharmaceuticals, Inc. Methods and compositions for treatment of cns disorders
US7888422B2 (en) 2005-11-09 2011-02-15 Mylan Technologies Inc. Long-wearing removable pressure sensitive adhesive
US20100121290A1 (en) * 2006-03-28 2010-05-13 Torben Rasmussen Multilayer Film
CN1895242B (zh) * 2006-04-13 2011-08-31 沈阳药科大学 双氯芬酸盐的透皮贴剂及制备方法
IL175338A0 (en) 2006-05-01 2006-09-05 Biota Ltd Orally administrable films and preparation thereof
JP5097359B2 (ja) * 2006-05-09 2012-12-12 久光製薬株式会社 ドネペジル経皮吸収型製剤
TW200815045A (en) 2006-06-29 2008-04-01 Jazz Pharmaceuticals Inc Pharmaceutical compositions of ropinirole and methods of use thereof
US9248104B2 (en) 2006-08-17 2016-02-02 Core Tech Solutions, Inc. Transdermal methods and systems for treating Alzheimer's disease
US20080107719A1 (en) 2006-11-08 2008-05-08 Sukhon Likitlersuang Transdermal drug delivery system
KR20090086565A (ko) 2006-12-01 2009-08-13 닛토덴코 가부시키가이샤 안정화된 도네페질 함유 접착 제제
KR101408454B1 (ko) 2006-12-01 2014-06-17 닛토덴코 가부시키가이샤 도네페질 함유 접착 제제의 착색을 억제하는 방법 및 도네페질의 친척 물질의 생성량을 감소시키는 방법
JP5403948B2 (ja) 2007-06-07 2014-01-29 久光製薬株式会社 メマンチン含有経皮吸収製剤
WO2009009649A1 (en) 2007-07-10 2009-01-15 Agile Therapeutics, Inc. Dermal delivery device with in situ seal
US9017301B2 (en) * 2007-09-04 2015-04-28 Mylan Technologies, Inc. Transdermal drug delivery systems comprising a coated release liner
JP2009203213A (ja) * 2008-02-28 2009-09-10 Kosumedei Seiyaku Kk 経皮吸収医薬組成物
KR101454362B1 (ko) 2008-03-24 2014-10-23 아이큐어 주식회사 도네페질을 유효성분으로 함유하는 치매 치료용경피흡수제제
EP2111857A1 (de) 2008-04-25 2009-10-28 Acino AG Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff hiervon
US20090291127A1 (en) 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
PE20100371A1 (es) 2008-10-31 2010-06-01 Lexicon Pharmaceuticals Inc Agonistas del receptor s1p para el tratamiento de malaria cerebral
US20100178037A1 (en) 2009-01-12 2010-07-15 Te-Wei Chen Display apparatus, video generation apparatus, and method thereof
WO2010126124A1 (ja) 2009-05-01 2010-11-04 久光製薬株式会社 経皮吸収型製剤
CN102630160B (zh) 2009-09-16 2014-05-07 株式会社三养生物制药 透皮递送系统、其制备方法以及使用所述系统的透皮递送方法
BR112012011334A2 (pt) 2009-10-21 2020-08-25 Teikoku Seiyaku Co., Ltd. formulação transdermicamente absorvível contendo donepezil
CN102048678A (zh) * 2009-10-30 2011-05-11 北京隆旗生物科技有限公司 一种奥昔布宁的透皮吸收制剂及其制备方法与药物应用
GB0921481D0 (en) 2009-12-08 2010-01-20 Vectura Ltd Process and product
CA2785639A1 (en) * 2009-12-30 2011-07-07 Novartis Ag Melt extruded nicotine thin strips
US20100178307A1 (en) 2010-01-13 2010-07-15 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
US9370495B2 (en) 2010-02-24 2016-06-21 Hisamitsu Pharmaceutical Co., Inc. Adhesive patch
US20110244023A1 (en) * 2010-03-30 2011-10-06 Phosphagenics Limited Transdermal delivery patch
US20130053358A1 (en) 2010-04-28 2013-02-28 Hisamitsu Pharmaceutical Co., Inc. Transdermally absorbable donepezil-containing preparation
US9012511B2 (en) 2010-05-19 2015-04-21 Alkermes Pharma Ireland Limited Nanoparticulate cinacalcet compositions
NZ605352A (en) * 2010-06-30 2013-10-25 Nal Pharmaceuticals Ltd Process for producing glycosaminoglycans
US20140370076A1 (en) 2010-06-30 2014-12-18 Nal Pharmaceuticals, Ltd. Transdermal drug delivery system containing donepezil
PL2598119T3 (pl) 2010-07-29 2019-03-29 Allergan, Inc. Niezawierające konserwantów roztwory brymonidyny i timololu
MX2013004123A (es) 2010-10-12 2013-12-16 Univ Johns Hopkins Composiciones antitusigenas que comprenden memantina.
JP5699554B2 (ja) 2010-11-11 2015-04-15 富士通株式会社 ベクトル処理回路、命令発行制御方法、及びプロセッサシステム
CN103200944B (zh) 2010-11-17 2016-05-04 赫克萨尔股份公司 包含丁丙诺啡的经皮治疗系统
WO2012084969A1 (en) 2010-12-22 2012-06-28 Hexal Ag Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition
EP2658576A1 (en) * 2010-12-29 2013-11-06 Pharmafilm S.R.L. Medicated patch for improved transdermal permeation of diclofenac diethylammonium
TWI433904B (zh) 2011-01-12 2014-04-11 Taiwan Biotech Co Ltd 多奈哌齊經皮貼片
CN102775476B (zh) 2011-05-12 2015-01-07 上海天伟生物制药有限公司 一种米卡芬净钠盐的制备方法
US8673338B2 (en) 2011-07-29 2014-03-18 Massachusetts Eye And Ear Infirmary Methods of delivering pharmaceutical agents
JP5808214B2 (ja) 2011-09-30 2015-11-10 株式会社トクヤマ 貼付剤
KR101239150B1 (ko) 2012-02-28 2013-03-06 에스케이케미칼주식회사 도네페질-함유 경피흡수제제 및 그의 제조방법
US9408802B1 (en) * 2012-03-22 2016-08-09 Prosolus, Inc. Seven day drug in adhesive transdermal delivery
US9145907B2 (en) 2012-08-28 2015-09-29 Hsiutao Liang Pipe connector
US20140256690A1 (en) 2013-03-08 2014-09-11 Agile Therapeutics, Inc. Contraceptive method
WO2014174564A1 (ja) 2013-04-22 2014-10-30 祐徳薬品工業株式会社 メマンチン含有経皮吸収型貼付製剤
JP5415645B1 (ja) * 2013-06-28 2014-02-12 久光製薬株式会社 貼付剤の製造方法、貼付剤及び包装体
US20160199317A1 (en) * 2013-08-30 2016-07-14 3M Innovative Properties Company Estradiol containing transdermal drug delivery systems and compositions
TWI704933B (zh) 2013-10-07 2020-09-21 美商帝國製藥美國股份有限公司 右美托咪啶經皮輸送裝置及使用其之方法
ES2831319T3 (es) 2013-11-17 2021-06-08 Medrx Co Ltd Formulación líquida coloidal absorbente transdérmica
KR101485822B1 (ko) 2014-01-22 2015-01-23 주식회사 대웅제약 도네페질 또는 그의 염을 함유하는 경피흡수제제
JP2015151370A (ja) * 2014-02-14 2015-08-24 日東電工株式会社 貼付製剤
EP3160461A1 (en) 2014-06-24 2017-05-03 KAT Transdermals LLC Transdermal delivery system
ES2784756T3 (es) * 2014-07-18 2020-09-30 Buzzz Pharmaceuticals Ltd Parche transdérmico opioide/antagonista de opioides disuasivo del abuso
JP6577795B2 (ja) 2014-09-03 2019-09-18 日東電工株式会社 ビスホスホネート剤を含む細胞性免疫用ワクチン医薬組成物
WO2016046675A1 (en) 2014-09-28 2016-03-31 Mohan M Alapati Compositions and methods for the treatment of neurological diseases
RU2713207C2 (ru) 2014-12-18 2020-02-04 Айкьюре Фармасьютикал Инк. Трансдермальная композиция, содержащая донепезил в качестве активного ингредиента
CA2975312A1 (en) 2015-01-28 2016-08-04 Dnx Biotech, Llc Compositions and methods of using a soluble tnf-alpha receptor modified for increased half-life
JP2018518502A (ja) 2015-06-22 2018-07-12 コリウム インターナショナル, インコーポレイテッド 難溶性治療剤を含む経皮接着性組成物
EP3329914A4 (en) 2015-07-27 2019-04-03 Hisamitsu Pharmaceutical Co., Inc. METHOD FOR PRODUCING AN ASENAPY-CONTAINING PLASTER
SG11201805570WA (en) 2015-12-30 2018-07-30 Corium Int Inc Systems and methods for long term transdermal administration
WO2017223402A1 (en) 2016-06-23 2017-12-28 Corium International, Inc. Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
RU2764764C2 (ru) 2016-07-27 2022-01-21 Кориум Интернэшнл, Инк. Трансдермальные системы доставки мемантина
US20180028663A1 (en) 2016-07-27 2018-02-01 Corium International, Inc. Sodium bicarbonate in situ conversion driven transdermal delivery of amine drug
CN109789134A (zh) 2016-07-27 2019-05-21 考里安国际公司 与口服递送药代动力学生物等效的透皮递送系统
CA3071007A1 (en) * 2017-07-26 2019-01-31 Corium, Inc. Transdermal delivery system with a microporous membrane having solvent-filled pores

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101460156A (zh) * 2006-05-08 2009-06-17 帝国制药株式会社 抗痴呆药的经皮吸收制剂
CN101568340A (zh) * 2006-12-01 2009-10-28 日东电工株式会社 经皮吸收制剂
CN101969937A (zh) * 2008-03-11 2011-02-09 Lts勒曼治疗系统股份公司 具有稳定化膜的透皮治疗系统
WO2010083035A2 (en) * 2009-01-14 2010-07-22 Corium International, Inc. Transdermal administration of tamsulosin
CN102834093A (zh) * 2009-12-16 2012-12-19 帝国制药株式会社 抗痴呆药物的经皮吸收制剂
CN103068377A (zh) * 2010-06-17 2013-04-24 Lts勒曼治疗系统股份公司 透皮施用美金刚
CN105611917A (zh) * 2013-10-11 2016-05-25 帝国制药美国公司 局部鞘氨醇-1-磷酸酯受体激动剂制剂及其使用方法
CN105693556A (zh) * 2016-03-01 2016-06-22 巴斯特医药科技(常州)有限公司 卡巴拉汀酒石酸盐的转化方法及其产物制成的贴片

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Spotlight on Rivastigmine Transdermal Patch In Dementia of the Alzheimer"s Type;Sohita Dhillon;《Drugs & Aging》;20120831;第28卷(第11期);第927-930页 *
卡巴拉汀经皮给药制剂的研究;郭淼;《中国优秀博硕士学位论文全文数据库(硕士)医药卫生科技辑》;20110115(第01期);第1-57页 *

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