CN102630160B - 透皮递送系统、其制备方法以及使用所述系统的透皮递送方法 - Google Patents
透皮递送系统、其制备方法以及使用所述系统的透皮递送方法 Download PDFInfo
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- 229920000184 poly(octadecyl acrylate) Polymers 0.000 description 1
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- 239000005020 polyethylene terephthalate Substances 0.000 description 1
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
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- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 description 1
- 229960001879 ropinirole Drugs 0.000 description 1
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
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- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
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- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 description 1
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- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
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- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
成分 | 含量(wt%) |
丙烯酸酯粘胶DT87-502 | 67% |
利斯的明 | 16% |
PGML | 2% |
硅酮粘胶PSA 7-4501 | 15% |
成分 | 含量(wt%) |
丙烯酸酯粘胶DT87-502 | 82% |
利斯的明 | 16% |
PGML | 2% |
比较例1 | 阳性对照1 | 比较 | |
终末半衰期(hr) | 7.1 | 11.3 | 商购贴剂的63% |
实施例1 | 阳性对照2 | 比较 | |
终末半衰期(hr) | 15.28 | 12.79 | 商购贴剂的120% |
受试材料 | 原发刺激指数(PII) | 皮肤刺激程度 |
实施例1 | 0.165 | 无刺激 |
阳性对照2 | 1.5 | 轻度刺激 |
Claims (9)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US24285409P | 2009-09-16 | 2009-09-16 | |
US61/242,854 | 2009-09-16 | ||
KR20090106090 | 2009-11-04 | ||
KR10-2009-0106090 | 2009-11-04 | ||
PCT/KR2010/006251 WO2011034323A2 (en) | 2009-09-16 | 2010-09-14 | Transdermal delivery system, method for manufacturing the same, and transdermal delivery method using the system |
Publications (2)
Publication Number | Publication Date |
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CN102630160A CN102630160A (zh) | 2012-08-08 |
CN102630160B true CN102630160B (zh) | 2014-05-07 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CN201080049146.5A Active CN102630160B (zh) | 2009-09-16 | 2010-09-14 | 透皮递送系统、其制备方法以及使用所述系统的透皮递送方法 |
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Country | Link |
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US (1) | US8864727B2 (zh) |
KR (1) | KR101325104B1 (zh) |
CN (1) | CN102630160B (zh) |
WO (1) | WO2011034323A2 (zh) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ605352A (en) * | 2010-06-30 | 2013-10-25 | Nal Pharmaceuticals Ltd | Process for producing glycosaminoglycans |
DE102010026903A1 (de) * | 2010-07-12 | 2012-01-12 | Amw Gmbh | Transdermales therapeutisches System mit Avocadoöl oder Palmöl als Hilfsstoff |
JP5725940B2 (ja) * | 2011-04-01 | 2015-05-27 | 日東電工株式会社 | ニコチン含有貼付製剤 |
WO2013006643A1 (en) | 2011-07-06 | 2013-01-10 | The Parkinson's Institute | Compositions and methods for treatment of symptoms in parkinson's disease patients |
WO2013023146A1 (en) | 2011-08-11 | 2013-02-14 | Attilio Difiore | Insert for luer connection |
KR101395557B1 (ko) * | 2011-08-25 | 2014-05-16 | 아이큐어 주식회사 | 경피 흡수 제제 및 그 제조방법 |
US8871245B2 (en) | 2012-02-28 | 2014-10-28 | Nichiban Co., Ltd. | Transdermal patch |
KR101239150B1 (ko) * | 2012-02-28 | 2013-03-06 | 에스케이케미칼주식회사 | 도네페질-함유 경피흡수제제 및 그의 제조방법 |
US9422463B2 (en) * | 2012-02-29 | 2016-08-23 | Hollister, Inc. | Buffered adhesive compositions for skin-adhering medical products |
FR2987561B1 (fr) * | 2012-03-02 | 2014-04-11 | Pf Medicament | Dispositif transdermique comprenant des micro-particules poreuses |
KR101964295B1 (ko) * | 2012-09-05 | 2019-04-01 | 주식회사 한독 | 피부 자극이 감소된 메만틴 경피전달 시스템 |
US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
CN105263488A (zh) * | 2013-03-15 | 2016-01-20 | 纳尔制药有限公司 | 含卡巴拉汀的经皮给药系统 |
CN104546804A (zh) * | 2013-10-09 | 2015-04-29 | 上海现代药物制剂工程研究中心有限公司 | 三维网状立体构型的透皮给药制剂及其制备方法 |
KR101558454B1 (ko) * | 2013-11-18 | 2015-10-06 | 조선대학교산학협력단 | 셀레질린 또는 그의 약학적으로 허용가능한 염을 함유하는 경피흡수제제 |
CN104666279A (zh) * | 2013-11-28 | 2015-06-03 | 上海现代药物制剂工程研究中心有限公司 | 载药的三维网状立体构型的透皮给药制剂及其制备方法 |
US20160354596A1 (en) * | 2014-01-16 | 2016-12-08 | Attwill Medical Solutions Steriflow L.P. | Active-agent inserts for connectors and related methods |
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US20110066120A1 (en) | 2011-03-17 |
WO2011034323A2 (en) | 2011-03-24 |
US8864727B2 (en) | 2014-10-21 |
KR101325104B1 (ko) | 2013-11-07 |
KR20110030349A (ko) | 2011-03-23 |
CN102630160A (zh) | 2012-08-08 |
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