CN1089581C - 含有包裹了极难溶于水的活性组分的冻干脂质体的药物制剂及其制备方法 - Google Patents

含有包裹了极难溶于水的活性组分的冻干脂质体的药物制剂及其制备方法 Download PDF

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Publication number
CN1089581C
CN1089581C CN98802737A CN98802737A CN1089581C CN 1089581 C CN1089581 C CN 1089581C CN 98802737 A CN98802737 A CN 98802737A CN 98802737 A CN98802737 A CN 98802737A CN 1089581 C CN1089581 C CN 1089581C
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CN
China
Prior art keywords
freeze
liposomes
trehalose
water
lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN98802737A
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English (en)
Chinese (zh)
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CN1248163A (zh
Inventor
G·卡瓦洛
L·玛奇托
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angelini Acraf SpA
Original Assignee
Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
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Publication date
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Publication of CN1248163A publication Critical patent/CN1248163A/zh
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Publication of CN1089581C publication Critical patent/CN1089581C/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN98802737A 1997-02-20 1998-02-12 含有包裹了极难溶于水的活性组分的冻干脂质体的药物制剂及其制备方法 Expired - Fee Related CN1089581C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI97A000362 1997-02-20
IT97MI000362A IT1289938B1 (it) 1997-02-20 1997-02-20 Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e

Publications (2)

Publication Number Publication Date
CN1248163A CN1248163A (zh) 2000-03-22
CN1089581C true CN1089581C (zh) 2002-08-28

Family

ID=11376097

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98802737A Expired - Fee Related CN1089581C (zh) 1997-02-20 1998-02-12 含有包裹了极难溶于水的活性组分的冻干脂质体的药物制剂及其制备方法

Country Status (25)

Country Link
US (1) US6319517B1 (https=)
EP (1) EP0981332B1 (https=)
JP (1) JP4290767B2 (https=)
KR (1) KR100496802B1 (https=)
CN (1) CN1089581C (https=)
AR (1) AR011681A1 (https=)
AT (1) ATE285754T1 (https=)
AU (1) AU744115B2 (https=)
BG (1) BG64580B1 (https=)
CA (1) CA2288958C (https=)
CZ (1) CZ295998B6 (https=)
DE (1) DE69828394T2 (https=)
EA (1) EA001637B1 (https=)
ES (1) ES2235320T3 (https=)
GE (1) GEP20022734B (https=)
HU (1) HU225593B1 (https=)
IL (1) IL131327A (https=)
IT (1) IT1289938B1 (https=)
PL (1) PL190628B1 (https=)
PT (1) PT981332E (https=)
SK (1) SK282931B6 (https=)
TR (1) TR199902025T2 (https=)
UA (1) UA70296C2 (https=)
WO (1) WO1998036736A1 (https=)
ZA (1) ZA981352B (https=)

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EP1192466B1 (en) 1999-06-23 2004-08-11 Cornell Research Foundation, Inc. Dehydration/rehydration of marked liposomes on a test device
US6576460B1 (en) 1999-10-28 2003-06-10 Cornell Research Foundation, Inc. Filtration-detection device and method of use
JP2006516571A (ja) * 2003-01-17 2006-07-06 スレッシュオールド ファーマシューティカルズ， インコーポレイテッド 良性前立腺増殖症の処置
AU2006235478B2 (en) 2005-04-12 2011-07-21 Elan Pharma International Limited Nanoparticulate and controlled release compositions comprising cyclosporine
US20080131496A1 (en) * 2006-09-22 2008-06-05 Guilford F Timothy Topical application of melatonin directly or in liposomes for the amelioration of itching and histamine and non histamine related inflammatory skin changes
CN101049504B (zh) * 2007-04-05 2010-05-19 广州立恩生物科技有限公司 一种脂质体药物载体及其制备方法
US9446147B2 (en) 2011-02-24 2016-09-20 The Ohio State University Membrane stabilizing compositions and methods
SI2768484T1 (sl) 2011-10-21 2019-12-31 Jazz Pharmaceuticals Research Llc Liofilizirani liposomi
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
US20150224221A1 (en) * 2012-08-31 2015-08-13 Chung-Ang University Industry-Academic Cooperation Foundation Method for preparing microspheres for emboli, and method for preparing microspheres to which drug-containing carrier is bound
US10722465B1 (en) 2017-12-08 2020-07-28 Quicksilber Scientific, Inc. Transparent colloidal vitamin supplement
US11344497B1 (en) 2017-12-08 2022-05-31 Quicksilver Scientific, Inc. Mitochondrial performance enhancement nanoemulsion
KR102646145B1 (ko) 2018-05-31 2024-03-11 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물
EA202092893A1 (ru) 2018-06-27 2021-04-19 Брес Терапьютикс Гмбх Фармацевтические композиции в лиофилизированной форме
JP7526103B2 (ja) * 2018-06-27 2024-07-31 ブレス テラポイティクス ゲーエムベーハー 大環状免疫抑制剤を含む吸入用組成物
KR102058961B1 (ko) 2018-07-28 2019-12-24 주식회사 엑소코바이오 엑소좀의 동결건조 방법
KR102163806B1 (ko) 2018-07-30 2020-10-07 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피지분비 감소용 조성물
EA202092892A1 (ru) 2018-12-04 2021-05-27 Брес Терапьютикс Гмбх Ингаляционные композиции, содержащие макроциклические иммуносупрессанты
US11291702B1 (en) 2019-04-15 2022-04-05 Quicksilver Scientific, Inc. Liver activation nanoemulsion, solid binding composition, and toxin excretion enhancement method
WO2020261158A1 (en) 2019-06-25 2020-12-30 Translatum Medicus Inc. Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN111358955B (zh) * 2020-04-01 2023-05-02 重庆理工大学 一种用于治疗脂质代谢疾病的炎症靶向的宾达利纳米粒、制备方法及其应用
JP7508359B2 (ja) 2020-12-11 2024-07-01 株式会社東芝 脂質粒子の製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4587319A (en) * 1983-03-18 1986-05-06 Beghin-Say S.A. Salified acrylic allyloligosaccharide copolymer, a process for preparing the copolymer, and application as a super-absorbent

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CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US4963362A (en) * 1987-08-07 1990-10-16 Regents Of The University Of Minnesota Freeze-dried liposome mixture containing cyclosporin
US5683714A (en) * 1991-04-19 1997-11-04 Nexstar Pharmaceuticals, Inc. Liposomal cyclosporin pharmaceutical formulation
US5817336A (en) * 1993-04-02 1998-10-06 Orion-Yhtyma Oy Composition containing selegiline
GB9320668D0 (en) * 1993-10-07 1993-11-24 Secr Defence Liposomes containing particulare materials
ATE164515T1 (de) * 1993-11-05 1998-04-15 Amgen Inc Herstellung von liposomen und verfahren zur substanzverkapselung

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4587319A (en) * 1983-03-18 1986-05-06 Beghin-Say S.A. Salified acrylic allyloligosaccharide copolymer, a process for preparing the copolymer, and application as a super-absorbent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 103-200786, XP002900172 *

Also Published As

Publication number Publication date
US6319517B1 (en) 2001-11-20
CN1248163A (zh) 2000-03-22
TR199902025T2 (xx) 1999-11-22
EA199900751A1 (ru) 2000-10-30
SK282931B6 (sk) 2003-01-09
KR100496802B1 (ko) 2005-06-22
JP2001519776A (ja) 2001-10-23
EP0981332A1 (en) 2000-03-01
IT1289938B1 (it) 1998-10-19
AU6496998A (en) 1998-09-09
CA2288958A1 (en) 1998-08-27
UA70296A (uk) 2004-10-15
DE69828394T2 (de) 2005-12-08
BG64580B1 (bg) 2005-08-31
DE69828394D1 (de) 2005-02-03
HUP0001464A2 (hu) 2000-10-28
WO1998036736A1 (en) 1998-08-27
ITMI970362A1 (it) 1998-08-20
SK111099A3 (en) 2000-05-16
KR20000075479A (ko) 2000-12-15
EP0981332B1 (en) 2004-12-29
PL335207A1 (en) 2000-04-10
CZ295998B6 (cs) 2005-12-14
CA2288958C (en) 2007-08-21
AR011681A1 (es) 2000-08-30
HU225593B1 (en) 2007-05-02
CZ292599A3 (cs) 2000-01-12
HK1026148A1 (en) 2000-12-08
ES2235320T3 (es) 2005-07-01
BG103738A (en) 2000-05-31
JP4290767B2 (ja) 2009-07-08
EA001637B1 (ru) 2001-06-25
IL131327A0 (en) 2001-01-28
PT981332E (pt) 2005-05-31
ZA981352B (en) 1998-08-19
IL131327A (en) 2004-07-25
AU744115B2 (en) 2002-02-14
PL190628B1 (pl) 2005-12-30
HUP0001464A3 (en) 2001-12-28
ATE285754T1 (de) 2005-01-15
UA70296C2 (uk) 2004-10-15
GEP20022734B (en) 2002-07-25

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