AR011681A1 - Una composicion liofilizada que comprende trehalosa y liposomas de lipidos en los cuales se ha incorporado un principio biologicamente activo y un procedimiento para la liofilizacion de una composicion que comprende trehalosa y liposomas de lipidos - Google Patents
Una composicion liofilizada que comprende trehalosa y liposomas de lipidos en los cuales se ha incorporado un principio biologicamente activo y un procedimiento para la liofilizacion de una composicion que comprende trehalosa y liposomas de lipidosInfo
- Publication number
- AR011681A1 AR011681A1 ARP980100754A ARP980100754A AR011681A1 AR 011681 A1 AR011681 A1 AR 011681A1 AR P980100754 A ARP980100754 A AR P980100754A AR P980100754 A ARP980100754 A AR P980100754A AR 011681 A1 AR011681 A1 AR 011681A1
- Authority
- AR
- Argentina
- Prior art keywords
- liposomes
- trehalose
- biologically active
- active principle
- composition
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 9
- 239000000203 mixture Substances 0.000 title abstract 8
- 150000002632 lipids Chemical class 0.000 title abstract 7
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 title abstract 6
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 title abstract 6
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 title abstract 6
- 238000004108 freeze drying Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- -1 1-benzyl-1H-3-indazolyl Chemical group 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 238000001816 cooling Methods 0.000 abstract 2
- WDRYRZXSPDWGEB-UHFFFAOYSA-N lonidamine Chemical compound C12=CC=CC=C2C(C(=O)O)=NN1CC1=CC=C(Cl)C=C1Cl WDRYRZXSPDWGEB-UHFFFAOYSA-N 0.000 abstract 2
- MTHORRSSURHQPZ-UHFFFAOYSA-N 2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid Chemical compound C12=CC=CC=C2C(COC(C)(C)C(O)=O)=NN1CC1=CC=CC=C1 MTHORRSSURHQPZ-UHFFFAOYSA-N 0.000 abstract 1
- 229930105110 Cyclosporin A Natural products 0.000 abstract 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
- 108010036949 Cyclosporine Proteins 0.000 abstract 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 abstract 1
- 229950009949 bindarit Drugs 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 229960001265 ciclosporin Drugs 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 125000002519 galactosyl group Chemical group C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 abstract 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 1
- 125000005456 glyceride group Chemical group 0.000 abstract 1
- 150000002327 glycerophospholipids Chemical class 0.000 abstract 1
- 229960003538 lonidamine Drugs 0.000 abstract 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 abstract 1
- 229960003987 melatonin Drugs 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 150000003408 sphingolipids Chemical class 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI000362A IT1289938B1 (it) | 1997-02-20 | 1997-02-20 | Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011681A1 true AR011681A1 (es) | 2000-08-30 |
Family
ID=11376097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100754A AR011681A1 (es) | 1997-02-20 | 1998-02-20 | Una composicion liofilizada que comprende trehalosa y liposomas de lipidos en los cuales se ha incorporado un principio biologicamente activo y un procedimiento para la liofilizacion de una composicion que comprende trehalosa y liposomas de lipidos |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6319517B1 (https=) |
| EP (1) | EP0981332B1 (https=) |
| JP (1) | JP4290767B2 (https=) |
| KR (1) | KR100496802B1 (https=) |
| CN (1) | CN1089581C (https=) |
| AR (1) | AR011681A1 (https=) |
| AT (1) | ATE285754T1 (https=) |
| AU (1) | AU744115B2 (https=) |
| BG (1) | BG64580B1 (https=) |
| CA (1) | CA2288958C (https=) |
| CZ (1) | CZ295998B6 (https=) |
| DE (1) | DE69828394T2 (https=) |
| EA (1) | EA001637B1 (https=) |
| ES (1) | ES2235320T3 (https=) |
| GE (1) | GEP20022734B (https=) |
| HU (1) | HU225593B1 (https=) |
| IL (1) | IL131327A (https=) |
| IT (1) | IT1289938B1 (https=) |
| PL (1) | PL190628B1 (https=) |
| PT (1) | PT981332E (https=) |
| SK (1) | SK282931B6 (https=) |
| TR (1) | TR199902025T2 (https=) |
| UA (1) | UA70296A (https=) |
| WO (1) | WO1998036736A1 (https=) |
| ZA (1) | ZA981352B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU762944B2 (en) | 1999-06-23 | 2003-07-10 | Cornell Research Foundation Inc. | Dehydration/rehydration of marked liposomes on a test device |
| US6576460B1 (en) | 1999-10-28 | 2003-06-10 | Cornell Research Foundation, Inc. | Filtration-detection device and method of use |
| EP1592430A4 (en) * | 2003-01-17 | 2006-05-31 | Threshold Pharmaceuticals Inc | TREATMENT OF GOOD PROSTATE HYPERPLASIA BY MEANS OF ENERGYSTIC ACTIVE SUBSTANCES |
| US7825087B2 (en) | 2005-04-12 | 2010-11-02 | Elan Pharma International Limited | Nanoparticulate and controlled release compositions comprising cyclosporine |
| WO2008036979A2 (en) * | 2006-09-22 | 2008-03-27 | Guilford F Timothy | Topical application of melatonin directly or in liposomes for the amelioration of itching and histamine and non-histamine related inflammatory skin changes |
| CN101049504B (zh) * | 2007-04-05 | 2010-05-19 | 广州立恩生物科技有限公司 | 一种脂质体药物载体及其制备方法 |
| US9446147B2 (en) | 2011-02-24 | 2016-09-20 | The Ohio State University | Membrane stabilizing compositions and methods |
| EP3572071A1 (en) | 2011-10-21 | 2019-11-27 | Jazz Pharmaceuticals Research LLC | Lyophilized liposomes |
| US8999292B2 (en) | 2012-05-01 | 2015-04-07 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| JP5957610B2 (ja) * | 2012-08-31 | 2016-07-27 | チュンアン ユニバーシティー インダストリー アカデミック コアポレイション ファウンデイション | 塞栓用のミクロスフェアの製造方法及び薬物含有ナノ輸送体が結合されたミクロスフェアの製造方法 |
| US11344497B1 (en) | 2017-12-08 | 2022-05-31 | Quicksilver Scientific, Inc. | Mitochondrial performance enhancement nanoemulsion |
| US10722465B1 (en) | 2017-12-08 | 2020-07-28 | Quicksilber Scientific, Inc. | Transparent colloidal vitamin supplement |
| KR102649069B1 (ko) | 2018-05-31 | 2024-03-19 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 안면 홍조 개선용 조성물 |
| IL279760B2 (en) | 2018-06-27 | 2025-10-01 | Breath Therapeutics Gmbh | Pharmaceutical preparations in lyophilized form |
| CA3104443A1 (en) * | 2018-06-27 | 2020-01-02 | Breath Therapeutics Gmbh | Inhalable compositions comprising macrocyclic immunosuppressants |
| JP7079984B2 (ja) | 2018-07-28 | 2022-06-03 | エクソコバイオ インコーポレイテッド | エキソソームの凍結乾燥方法 |
| KR102163806B1 (ko) | 2018-07-30 | 2020-10-07 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피지분비 감소용 조성물 |
| EA202092892A1 (ru) | 2018-12-04 | 2021-05-27 | Брес Терапьютикс Гмбх | Ингаляционные композиции, содержащие макроциклические иммуносупрессанты |
| US11291702B1 (en) | 2019-04-15 | 2022-04-05 | Quicksilver Scientific, Inc. | Liver activation nanoemulsion, solid binding composition, and toxin excretion enhancement method |
| EP3990433A4 (en) | 2019-06-25 | 2023-07-26 | Translatum Medicus Inc. | METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES |
| CN111358955B (zh) * | 2020-04-01 | 2023-05-02 | 重庆理工大学 | 一种用于治疗脂质代谢疾病的炎症靶向的宾达利纳米粒、制备方法及其应用 |
| JP7508359B2 (ja) * | 2020-12-11 | 2024-07-01 | 株式会社東芝 | 脂質粒子の製造方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1173360A (en) * | 1979-06-22 | 1984-08-28 | Jurg Schrank | Pharmaceutical preparations |
| FR2542749B1 (fr) * | 1983-03-18 | 1985-07-12 | Beghin Say Sa | Copolymere allyloligosaccharide-acrylique salifie, procede de preparation du copolymere et application comme super-absorbant |
| US4857319A (en) * | 1985-01-11 | 1989-08-15 | The Regents Of The University Of California | Method for preserving liposomes |
| US4963362A (en) * | 1987-08-07 | 1990-10-16 | Regents Of The University Of Minnesota | Freeze-dried liposome mixture containing cyclosporin |
| US5683714A (en) * | 1991-04-19 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Liposomal cyclosporin pharmaceutical formulation |
| US5817336A (en) * | 1993-04-02 | 1998-10-06 | Orion-Yhtyma Oy | Composition containing selegiline |
| GB9320668D0 (en) * | 1993-10-07 | 1993-11-24 | Secr Defence | Liposomes containing particulare materials |
| AU683957B2 (en) * | 1993-11-05 | 1997-11-27 | Amgen, Inc. | Liposome preparation and material encapsulation method |
-
1997
- 1997-02-20 IT IT97MI000362A patent/IT1289938B1/it active IP Right Grant
-
1998
- 1998-02-12 SK SK1110-99A patent/SK282931B6/sk not_active IP Right Cessation
- 1998-02-12 HU HU0001464A patent/HU225593B1/hu not_active IP Right Cessation
- 1998-02-12 PT PT98910659T patent/PT981332E/pt unknown
- 1998-02-12 CN CN98802737A patent/CN1089581C/zh not_active Expired - Fee Related
- 1998-02-12 ES ES98910659T patent/ES2235320T3/es not_active Expired - Lifetime
- 1998-02-12 AU AU64969/98A patent/AU744115B2/en not_active Ceased
- 1998-02-12 EA EA199900751A patent/EA001637B1/ru not_active IP Right Cessation
- 1998-02-12 JP JP53622898A patent/JP4290767B2/ja not_active Expired - Fee Related
- 1998-02-12 IL IL13132798A patent/IL131327A/en not_active IP Right Cessation
- 1998-02-12 DE DE69828394T patent/DE69828394T2/de not_active Expired - Lifetime
- 1998-02-12 UA UA99095150A patent/UA70296A/uk unknown
- 1998-02-12 EP EP98910659A patent/EP0981332B1/en not_active Expired - Lifetime
- 1998-02-12 CA CA002288958A patent/CA2288958C/en not_active Expired - Fee Related
- 1998-02-12 AT AT98910659T patent/ATE285754T1/de active
- 1998-02-12 KR KR10-1999-7007538A patent/KR100496802B1/ko not_active Expired - Fee Related
- 1998-02-12 WO PCT/EP1998/000817 patent/WO1998036736A1/en not_active Ceased
- 1998-02-12 CZ CZ19992925A patent/CZ295998B6/cs not_active IP Right Cessation
- 1998-02-12 PL PL98335207A patent/PL190628B1/pl unknown
- 1998-02-12 US US09/367,715 patent/US6319517B1/en not_active Expired - Lifetime
- 1998-02-12 TR TR1999/02025T patent/TR199902025T2/xx unknown
- 1998-02-12 GE GEAP19984991A patent/GEP20022734B/en unknown
- 1998-02-18 ZA ZA981352A patent/ZA981352B/xx unknown
- 1998-02-20 AR ARP980100754A patent/AR011681A1/es active IP Right Grant
-
1999
- 1999-09-16 BG BG103738A patent/BG64580B1/bg unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FG | Grant, registration |