ES2186792T3 - Metodos de fabricar liposomas que contienen fotosensibilizantes hidro-monobenzoporfirinicos. - Google Patents
Metodos de fabricar liposomas que contienen fotosensibilizantes hidro-monobenzoporfirinicos.Info
- Publication number
- ES2186792T3 ES2186792T3 ES96925614T ES96925614T ES2186792T3 ES 2186792 T3 ES2186792 T3 ES 2186792T3 ES 96925614 T ES96925614 T ES 96925614T ES 96925614 T ES96925614 T ES 96925614T ES 2186792 T3 ES2186792 T3 ES 2186792T3
- Authority
- ES
- Spain
- Prior art keywords
- photosensitizers
- monobenzoporphyrinic
- methods
- liposomes containing
- manufacturing liposomes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
METODOS PARA HACER UNA COMPOSICION FARMACEUTICA QUE CONTIENE LIPOSOMAS, CUYOS LIPOSOMAS COMPRENDEN UNA CANTIDAD TERAPEUTICAMENTE ACEPTABLE DE UNA HIDROMONOBENZOPORFIRINA FOTOSENSIBILIZADORA Y UNA MEZCLA DE FOSFOLIPIDOS QUE COMPRENDEN FOSFATIDIL GLICEROL DE HUEVO ( EPG ) Y DIMIRISTOIL FOSFATIDIL COLINA ("DMPC ). EL METODO COMPRENDE LOS SIGUIENTES PASOS: A) COMBINACION DEL FOTOSENSIBILIZADOR Y DE LOS FOSFOLIPIDOS EN UNA RELACION MOLAR DE ALREDEDOR DE 1:7,0 O MAS FOSFOLIPIDOS EN PRESENCIA DE UN DISOLVENTE ORGANICO; B) ELIMINACION DEL DISOLVENTE ORGANICO PARA FORMAR UNA PELICULA LIPIDICA; C) HIDRATACION DE LA PELICULA LIPIDICA CON UNA SOLUCION ACUOSA A UNA TEMPERATURA POR DEBAJO DE UNOS 300 (GRADOS) C, PARA FORMAR LIPOSOMAS GROSEROS QUE CONTIENEN UN COMPLEJO FOTOSENSIBILIZADORFOSFOLIPIDO; Y D) HOMOGENEIZACION O REDUCCION DE LA DIMENSION DE LAS PARTICULAS DE LOS LIPOSOMAS GROSEROS HASTA UN RANGO DE TAMAÑO DE PARTICULA DE ALREDEDOR DE 150 A 300 NM A UNA TEMPERATURA POR DEBAJO DE UNOS 300 (GRADOS)C. LA INVENCION TAMBIEN CONTEMPLA LAS COMPOSICIONES FARMACEUTICAS LIPOSOMICAS EN SI MISMAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/510,573 US5707608A (en) | 1995-08-02 | 1995-08-02 | Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2186792T3 true ES2186792T3 (es) | 2003-05-16 |
Family
ID=24031289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96925614T Expired - Lifetime ES2186792T3 (es) | 1995-08-02 | 1996-07-29 | Metodos de fabricar liposomas que contienen fotosensibilizantes hidro-monobenzoporfirinicos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5707608A (es) |
EP (1) | EP0843547B1 (es) |
JP (1) | JP3782112B2 (es) |
AT (1) | ATE226430T1 (es) |
AU (1) | AU717181B2 (es) |
CA (1) | CA2227761C (es) |
DE (1) | DE69624485T2 (es) |
DK (1) | DK0843547T3 (es) |
ES (1) | ES2186792T3 (es) |
PT (1) | PT843547E (es) |
TW (1) | TW585785B (es) |
WO (1) | WO1997004746A1 (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69215722T3 (de) * | 1991-03-22 | 2001-03-08 | Katsuro Tachibana | Verstärker zur Ultraschalltherapie von Erkrankungen sowie diesen enthaltende flüssige Arzneimittelzusammensetzungen |
US6890555B1 (en) * | 1992-02-05 | 2005-05-10 | Qlt, Inc. | Liposome compositions of porphyrin photosensitizers |
US6176842B1 (en) | 1995-03-08 | 2001-01-23 | Ekos Corporation | Ultrasound assembly for use with light activated drugs |
US6210356B1 (en) * | 1998-08-05 | 2001-04-03 | Ekos Corporation | Ultrasound assembly for use with a catheter |
US6143287A (en) * | 1996-02-27 | 2000-11-07 | New York Blood Center, Inc. | Method and composition for hair removal |
CA2202103C (en) | 1996-04-11 | 2007-01-09 | Toshiaki Tagawa | Method for preparing closed vesicles |
JP2001511128A (ja) * | 1997-01-28 | 2001-08-07 | ファルマシア・アンド・アップジョン・カンパニー | 水不溶性ポルフィリンの脂質錯体の凍結乾燥物 |
US6582392B1 (en) * | 1998-05-01 | 2003-06-24 | Ekos Corporation | Ultrasound assembly for use with a catheter |
US6676626B1 (en) | 1998-05-01 | 2004-01-13 | Ekos Corporation | Ultrasound assembly with increased efficacy |
WO1999013916A2 (en) * | 1997-09-18 | 1999-03-25 | Nycomed Imaging As | Methods and compositions for medical imaging |
US6183727B1 (en) | 1998-05-19 | 2001-02-06 | Arizona Board Of Regents | Use of long-wavelength electromagnetic radiation and photoprotective tumor localizing agents for diagnosis |
US6608050B2 (en) * | 1999-07-20 | 2003-08-19 | Pharmacia & Upjohn Company | Lyophilizate of lipid complex of water insoluble porphyrins |
US6351663B1 (en) | 1999-09-10 | 2002-02-26 | Akorn, Inc. | Methods for diagnosing and treating conditions associated with abnormal vasculature using fluorescent dye angiography and dye-enhanced photocoagulation |
US6944493B2 (en) * | 1999-09-10 | 2005-09-13 | Akora, Inc. | Indocyanine green (ICG) compositions and related methods of use |
US6443976B1 (en) | 1999-11-30 | 2002-09-03 | Akorn, Inc. | Methods for treating conditions and illnesses associated with abnormal vasculature |
AU2001234979B2 (en) | 2000-02-10 | 2006-07-27 | Massachusetts Eye And Ear Infirmary | Methods and compositions for treating conditions of the eye |
IL151833A0 (en) * | 2000-03-24 | 2003-04-10 | Novartis Ag | Improved treatment of neovascularization |
WO2002064163A2 (en) | 2001-02-15 | 2002-08-22 | Qlt Inc. | Reduction or prevention of pdt related inflammation |
AU2007202603B2 (en) * | 2001-04-11 | 2010-06-10 | Valeant Pharmaceuticals International, Inc. | Drug delivery system for hydrophobic drugs |
US6984395B2 (en) * | 2001-04-11 | 2006-01-10 | Qlt, Inc. | Drug delivery system for hydrophobic drugs |
WO2003037295A2 (en) * | 2001-11-02 | 2003-05-08 | The Governors Of The University Of Alberta | Micelle compositions containing pegylated phospholipids and a photosensitizer |
ATE520362T1 (de) | 2001-12-03 | 2011-09-15 | Ekos Corp | Katheter mit mehreren ultraschall-abstrahlenden teilen |
US8226629B1 (en) | 2002-04-01 | 2012-07-24 | Ekos Corporation | Ultrasonic catheter power control |
US7455858B2 (en) * | 2002-05-16 | 2008-11-25 | Qlt Inc. | Compositions and methods for delivery of photosensitive drugs |
US6921371B2 (en) * | 2002-10-14 | 2005-07-26 | Ekos Corporation | Ultrasound radiating members for catheter |
US20040220167A1 (en) * | 2003-05-02 | 2004-11-04 | Nasrollah Samiy | Methods of treating neuralgic pain |
JP4741205B2 (ja) * | 2003-07-07 | 2011-08-03 | 真 湯浅 | 金属ポルフィリン錯体包埋リポソーム、その製造方法およびこれを利用する医薬 |
US7682603B2 (en) * | 2003-07-25 | 2010-03-23 | The Trustees Of The University Of Pennsylvania | Polymersomes incorporating highly emissive probes |
US20050048109A1 (en) * | 2003-08-26 | 2005-03-03 | Ceramoptec Industries, Inc. | Non-polar photosensitizer formulations for photodynamic therapy |
US7341569B2 (en) | 2004-01-30 | 2008-03-11 | Ekos Corporation | Treatment of vascular occlusions using ultrasonic energy and microbubbles |
US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
EP1874197A4 (en) * | 2005-04-12 | 2010-02-10 | Ekos Corp | ULTRASONIC SURFACE CATHETER PROMOTING CAVITATION |
EP2015846A2 (en) | 2006-04-24 | 2009-01-21 | Ekos Corporation | Ultrasound therapy system |
US10182833B2 (en) | 2007-01-08 | 2019-01-22 | Ekos Corporation | Power parameters for ultrasonic catheter |
WO2008088037A1 (ja) * | 2007-01-18 | 2008-07-24 | National University Corporation Chiba University | 微粒子製剤 |
EP2494932B1 (en) | 2007-06-22 | 2020-05-20 | Ekos Corporation | Apparatus for treatment of intracranial hemorrhages |
EP2231024A4 (en) * | 2007-12-14 | 2015-03-18 | Ekos Corp | ULTRASOUND PULSE SHAPING |
US9211214B2 (en) | 2012-03-21 | 2015-12-15 | Valeant Pharmaceuticals International, Inc | Photodynamic therapy laser |
US10918599B2 (en) * | 2015-04-02 | 2021-02-16 | The Research Foundation For The State University Of New York | Serum-stable compositions and methods for light-triggered release of materials |
EP3307388B1 (en) | 2015-06-10 | 2022-06-22 | Ekos Corporation | Ultrasound catheter |
JP7079937B2 (ja) | 2016-05-26 | 2022-06-03 | ユニバーシティ オブ ピッツバーグ -オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 肺血管疾患を治療するための組成物および方法 |
KR102035384B1 (ko) * | 2017-06-26 | 2019-10-22 | 서강대학교산학협력단 | 광감작제를 포함한 마이크로버블-나노입자 복합체 및 이를 포함하는 항암 치료제 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4500507A (en) * | 1981-10-30 | 1985-02-19 | Wong Dennis W | Diagnostic composition for radiologic imaging of neoplasms in the body and method of preparation |
US4649151A (en) * | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
US4577636A (en) * | 1982-11-23 | 1986-03-25 | The Beth Israel Hospital Association | Method for diagnosis of atherosclerosis |
US4517762A (en) * | 1983-07-08 | 1985-05-21 | Venetz Louis M | Animal trap holder |
US4485806A (en) * | 1983-10-24 | 1984-12-04 | Calspan Corporation | Method and apparatus for evacuating contaminated casualties |
US4753958A (en) * | 1985-02-07 | 1988-06-28 | University Of Cal | Photochemotherapy of epithelial diseases with derivatives of hematoporphyrins |
US4776991A (en) * | 1986-08-29 | 1988-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Scaled-up production of liposome-encapsulated hemoglobin |
US4933121A (en) * | 1986-12-10 | 1990-06-12 | Ciba Corning Diagnostics Corp. | Process for forming liposomes |
US4883790A (en) * | 1987-01-20 | 1989-11-28 | University Of British Columbia | Wavelength-specific cytotoxic agents |
US4920143A (en) * | 1987-04-23 | 1990-04-24 | University Of British Columbia | Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents |
US5010073A (en) * | 1989-10-05 | 1991-04-23 | The Rockefeller University | Use of liposomes as carriers for metalloporphyrins |
US5214036A (en) * | 1990-03-08 | 1993-05-25 | University Of British Columbia | Benzoporphyrin derivatives for photodynamic therapy |
US5053423A (en) * | 1990-03-22 | 1991-10-01 | Quadra Logic Technologies Inc. | Compositions for photodynamic therapy |
US5238940A (en) * | 1990-03-22 | 1993-08-24 | Quadra Logic Technologies Inc. | Compositions for photodynamic therapy |
US5270053A (en) * | 1990-04-03 | 1993-12-14 | Ciba-Geigy Corp. | Parenterally administerable liposome formulation comprising synthetic lipid |
CA2047969A1 (en) * | 1990-08-17 | 1992-02-18 | Thomas D. Madden | Benzoporphyrin vesicles |
CA2087902C (en) * | 1992-02-05 | 2006-10-17 | Narendra Raghunathji Desai | Liposome compositions of porphyrin photosensitizers |
US5422362A (en) * | 1993-07-29 | 1995-06-06 | Quadra Logic Technologies, Inc. | Method to inhibit restenosis |
-
1995
- 1995-08-02 US US08/510,573 patent/US5707608A/en not_active Expired - Lifetime
-
1996
- 1996-07-29 DK DK96925614T patent/DK0843547T3/da active
- 1996-07-29 WO PCT/CA1996/000512 patent/WO1997004746A1/en active IP Right Grant
- 1996-07-29 DE DE69624485T patent/DE69624485T2/de not_active Expired - Lifetime
- 1996-07-29 CA CA002227761A patent/CA2227761C/en not_active Expired - Lifetime
- 1996-07-29 ES ES96925614T patent/ES2186792T3/es not_active Expired - Lifetime
- 1996-07-29 AU AU66083/96A patent/AU717181B2/en not_active Expired
- 1996-07-29 AT AT96925614T patent/ATE226430T1/de active
- 1996-07-29 EP EP96925614A patent/EP0843547B1/en not_active Expired - Lifetime
- 1996-07-29 PT PT96925614T patent/PT843547E/pt unknown
- 1996-07-29 JP JP53435996A patent/JP3782112B2/ja not_active Expired - Lifetime
- 1996-07-30 TW TW085109287A patent/TW585785B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0843547B1 (en) | 2002-10-23 |
AU717181B2 (en) | 2000-03-16 |
CA2227761A1 (en) | 1997-02-13 |
DE69624485T2 (de) | 2003-06-26 |
DE69624485D1 (de) | 2002-11-28 |
PT843547E (pt) | 2003-03-31 |
EP0843547A1 (en) | 1998-05-27 |
ATE226430T1 (de) | 2002-11-15 |
TW585785B (en) | 2004-05-01 |
WO1997004746A1 (en) | 1997-02-13 |
JP3782112B2 (ja) | 2006-06-07 |
AU6608396A (en) | 1997-02-26 |
DK0843547T3 (da) | 2003-02-24 |
US5707608A (en) | 1998-01-13 |
CA2227761C (en) | 2004-01-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2186792T3 (es) | Metodos de fabricar liposomas que contienen fotosensibilizantes hidro-monobenzoporfirinicos. | |
ES2153053T3 (es) | Liposomas de eter-lipido y su uso terapeutico. | |
PA8481501A1 (es) | 4-carboxiamino-2-metil-1,2,3,4-tetrahidroquinolinas | |
ATE192924T1 (de) | Liposomal verkapseltes taxol, seine herstellung und seine verwendung | |
ES2036593T3 (es) | Composiciones que utilizan medicamentos antiinflamatorios no esteroidales encapsulados en liposomas. | |
FI965144A0 (fi) | Sterolijohdannaiset käytettäviksi meioosin säätelyyn | |
TR199800415T1 (en) | Farmas�tik form�lasyon. | |
ES2182869T3 (es) | Sacarido no reductor y su uso. | |
HN2002000327A (es) | DERIVADOS DE TRIAZOLO [4, 3-a] PIRIDO [2, 3-d] PIRIMIDIN-5-ONA, COMPOSICIONES QUE LOS CONTIENEN, METODO DE PREPARACION Y USO | |
GR3018810T3 (en) | 5,6-dihydroxyindoline as additives for hair-dyeing preparations. | |
ATE159250T1 (de) | Neue pyrazinderivative, ihre herstellung und verwendung | |
ATE233484T1 (de) | Desinfizierende zusammensetzung | |
DE59912159D1 (de) | Phospholipide mit ungesattigten alkyl- und acylketten | |
ES2041617T1 (es) | Intermediarios para agentes quelatinosos con simetria prefijada y proceso para su preparacion. | |
TR200401051T4 (tr) | 3-amino-2-kloro-4-etilpiridin yapım işlemi | |
JPS55160712A (en) | Emulsified cosmetic composition | |
ID27440A (id) | Proses untuk menyiapkan penengah-penengah | |
DE3851842D1 (de) | Wässrige bereitung von liposomenzusammensetzungen. | |
TR199900748A2 (xx) | Osteinduktif protein ve dorsalize faktörünün kombinasyonunun kullanılması. | |
SE8400118L (sv) | Substituerade karboxi-tiazolo/3,2-a/pyrimidinderivat och forfarande for deras framstellning | |
RU94027343A (ru) | Липосомальная везикула с цитохромом с | |
ES8206507A1 (es) | Procedimiento para la obtencion de las sustancias odoriferas metil-4-oxatricilo 5,2,1,0,6-dec-8-en-3-ona y decan-3-ona. | |
Chiesi | Characteristics of cardiac sarcoplasmic reticulum and of its Ca-(2+)-pumping enzyme: a comparative study with fast skeletal muscle | |
ES2106858T3 (es) | Nuevos derivados de la citarabina, su procedimiento de preparacion y su uso contra enfermedades cancerosas. | |
ECSP003415A (es) | Derivados de 3-amino,3-arilpropan- 1 - ol, su preparacion y su uso |